The The Correlation between Anti-Cytomegalovirus and AntiToxoplasma gondii Antibodies with the Plasma Level of Glycosylated Hemoglobin
Novelty in Biomedicine,
Vol. 10 No. 1 (2022),
31 January 2022
,
Page 34-36
https://doi.org/10.22037/nbm.v10i1.35925
Abstract
Background: Viral infections play an important role in the pathogenesis of diabetes mellitus (DM). The
association between some viral infections, including cytomegalovirus (CMV) and the development of DM was
reported by some articles, but about T. gondii data is limited. We aimed to evaluate the correlation between antiCMV and anti-Toxoplasma gondii (T. gondii) antibodies with the plasma level of glycosylated hemoglobin
(HbA1C).
Materials and Methods: This is a cross-sectional retrospective study conducted on the medical records of women who tested for pre-pregnancy checkups and had antibody levels against CMV and/or T. gondii, and plasma level
of HbA1C.
Results: During 4 years, data from 117 patients with anti-CMV IgG, and 186 with anti-T. gondii IgG was
finally analyzed. According to the data, we did not detect any correlation between the plasma levels of HbA1C
and IgG levels against CMV (Correlation Coefficient 0.150, p = 0.108) and T. gaondii (Correlation Coefficient
0.076, p = 0.300).
Conclusion: In conclusion, we recommended a large-scale controlled clinical trial to compare the plasma level
of HbA1C between patients with confirmed CMV or T. gondii infection and the control group.
- Diabetes Mellitus, Cytomegalovirus, Toxoplasma gondii, antibodies, glycosylated hemoglobin
How to Cite
References
Christen U, Bender C, von Herrath MG. Infection as a cause of type 1 diabetes? Current opinion in rheumatology. 2012;24(4):417-23.
Seewaldt S, Thomas HE, Ejrnaes M, Christen U, Wolfe T, Rodrigo E, et al. Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes. Diabetes. 2000;49(11):1801-9.
Jaeckel E, Manns M, Von Herrath M. Viruses and diabetes. Annals of the New York Academy of Sciences. 2002;958:7-25.
Ahmad-Abakur EH, Abdelkareem MA, Abrahim-Holi MA, Ali A. Associations of cytomegalovirus with type I diabetes mellitus among children in Khartoum State. African Journal of Microbiology Research. 2014;8(16):1730-4.
Pak C, Mcarthur R, Eun H-M, Yoon J-W. Association of cytomegalovirus infection with autoimmune type 1 diabetes. The Lancet. 1988;332(8601):1-4.
Alia B, Mahdi W. Association of cytomegalo virus with type I diabetes mellitus among children in Minia Governorate. African Journal of Clinical and Experimental Microbiology. 2015;16(3):86-91.
Hjelmesaeth J, Sagedal S, Hartmann A, Rollag H, Egeland T, Hagen M, et al. Asymptomatic cytomegalovirus infection is associated with increased risk of new-onset diabetes mellitus and impaired insulin release after renal transplantation. Diabetologia. 2004;47(9):1550-6.
Yoo SG, Do Han K, Lee KH, La Y, Kwon DE, Han SH. Impact of Cytomegalovirus disease on new-onset type 2 diabetes mellitus: population-based matched case-control cohort study. Diabetes & metabolism journal. 2019;43(6):815.
Alvarado-Esquivel C, Loera-Moncivais N, Hernandez-Tinoco J, Sanchez-Anguiano LF, Hernandez-Madrid G, Rabago-Sanchez E, et al. Lack of Association Between Toxoplasma gondii Infection and Diabetes Mellitus: A Matched Case-Control Study in a Mexican Population. Journal of clinical medicine research. 2017;9(6):508-11.
Nosaka K, Hunter M, Wang W. The association between Toxoplasma gondii and type 2 diabetes mellitus: a systematic review and meta-analysis of human case-control studies. Bulletin of the National Research Centre. 2020;44(1):1-9.
Majidiani H, Dalvand S, Daryani A, Galvan-Ramirez ML, Foroutan-Rad M. Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case-control studies. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. 2016;20(6):605-9.
Shirbazou S, Delpisheh A, Mokhetari R, Tavakoli G. Serologic Detection of Anti Toxoplasma gondii Infection in Diabetic Patients. Iran Red Crescent Med J. 2013;15(8):701-3.
Beshay EVN, El-Refai SA, Helwa MA, Atia AF, Dawoud MM. Toxoplasma gondii as a possible causative pathogen of type-1 diabetes mellitus: evidence from case-control and experimental studies. Experimental parasitology. 2018;188:93-101.
Chen S, De Craen AJ, Raz Y, Derhovanessian E, CTM AV, GJ RW, et al. Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study. Immunity & Ageing. 2012;9(1):1-7.
Majidiani H, Dalvand S, Daryani A, Galvan-Ramirez MdlL, Foroutan-Rad M. Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case-control studies. Brazilian Journal of Infectious Diseases. 2016;20(6):605-9.
- Abstract Viewed: 105 times
- pdf Downloaded: 106 times