Heart Diseases Associated Genes
Novelty in Biomedicine,
Vol. 8 No. 3 (2020),
13 July 2020
AbstractBackground: Heart diseases are complex pathophysiologic conditions involving biomarkers. Understanding the mechanisms by which a gene selectively triggers intracellular molecular responses provide insight into the complex processes implicated in heart diseases. The aim of this study was to predict heart diseases associated genes.
Materials and Methods: A number of computational methods have been developed for human gene prioritization. In this study, we used Beegle and KEGG pathway databases and two online services for gene prioritization and analysis of genes related to heart disease.
Results: Over 200 genes and 5 key signaling pathways related to human heart diseases were found. The processes in which gene mutations trigger a response in cells leading to cardiac conditions involve multiple pathways.
Conclusion: The genes related to heart diseases could be CRP, NPPB, IL-6, ACE2 and GATA4 with high scores and the researchers should find the diagnostic biomarker between them.
- Genes, Heart diseases, System biology
Berry JD, Lloyd-Jones DM, Garside DB, Greenland P. Framingham risk score and prediction of coronary heart disease death in young men. Am Heart J. 2007;154(1):80-6.
Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N. Engl J Med. 2005; 352(16):1685-95.
Califano JP, Reinhart-King CA. Exogenous and endogenous force regulation of endothelial cell behavior. J. Biomech. 2010;43(1):79-86.
Lu D, Kassab G. Role of shear stress and stretch in vascular mechanobiology. J R Soc Interface. 2011;8(63):1379-85.
Marian AJ. Pathogenesis of diverse clinical and pathological phenotypes in hypertrophic cardiomyopathy. Lancet. 2000;355(9197):58-60.
Sen-Chowdhry S, Syrris P, McKenna WJ. Genetics of right ventricular cardiomyopathy. J Cardiovasc Electrophysiol. 2005;16(8):927-35.
Miura K, Nkagawa Y, Sasayama S, Matsumori A, et al. Epidemiology of idiopathic cardiomyopathy in Japan: results from a nationwide survey. Heart Rhythm, 2002;87(2):126-30.
Sagar S, Liu PP, Cooper LT. Myocarditis. The Lancet. 2012.379(9817):738-47.
Morita H, Depalma SR, Arad M, McDonough B, Barr S. Molecular epidemiology of hypertrophic cardiomyopathy. . Cold Spring Harb Symp Quant. 2002;67:383–8.
Kamisago M, Sharma S, Depalma S, Solomon S, Shama P, et al. Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N Engl J Med. 2000;343:1688-96.
Herman DS, Lam L, Taylor M, Wang L, Teekakirikul P. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012;366(7):619-28.
McKoy G, Protonotarios N, Crosby A, Tsatsopoulou A, Anastasakis A, et al. Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). Lancet. 2002;355(9221):2119-24.
Mederos y Schnitzler M, Storch U, Gudermann T. AT1 receptors as mechanosensors. Curr Opin Pharmacol.. 2010;11(2):112-6.
Lavallée M, Takamura M, Parent R, Thorin E. Crosstalk between endothelin and nitric oxide in the control of vascular tone. Heart Fail Rev. 2001;6:265-7.
Rigazio CS, Hernandez M, Corral RS. Cardiopathogenic mediators generated by GATA4 signaling upon co-activation with endothelin-1 and Trypanosoma cruzi infection. Microb Pathog. 2014;73:47-52.
Högye M, Mandi Y, Csanády M, Sepp R, Buzas K. Comparison of circulating levels of interleukin-6 and tumor necrosis factor-alpha in hypertrophic cardiomyopathy and in idiopathic dilated cardiomyopathy. Am J Cardiol. 2004;94(2):249-51.
Ackerman MJ, Priori SG, Willems S, Berul C, Brugada R, et al. HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart Rhythm. 2011;8(8):1308-39.
Herren T, Gerber P, Duru F. Arrhythmogenic right ventricular cardiomyopathy/dysplasia: a not so rare Bdisease of the desmosome^ with multiple clinical presentations. Clin Res Cardiol. 2009;98(3):141-58.
Zen K, Irie H, Doue T, Takamiya M, Yamano T, Sawada T, Azuma A, Matsubara H. Analysis of circulating apoptosis mediators and proinflammatory cytokines in patients with idiopathic hypertrophic cardiomyopathy: comparison between nonobstructive and dilated-phase hypertrophic cardiomyopathy. Int Heart J. 2005;46(2):231-44.
Ogino K, Ogura K, Kinugawa T, Osaki S, Kato M, Furuse Y et al. Neurohumoral profiles in patients with hypertrophic cardiomyopathy: differences to hypertensive left ventricular hypertrophy. Circ J. 2004;68(5):444-50.
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