Abdominal Burkitt’s lymphoma in Children
Iranian Journal of Pediatric Surgery,
Vol. 1 No. 1 (2015),
1 September 2015
Background: Burkitt’s lymphoma is a high grade B-cell neoplasm, which is a kind of small non-cleaved cell lymphoma. It is presumably the fastest growing human malignancy, and the patients are prone to develop tumor-lysis syndrome. Here we present findings on our patients with Burkitt lymphoma.
Materials and Methods: This descriptive retrospective study included 46 children with abdominal Burkitt's lymphoma who were treated during 15 years from June 1998 to Dec 2013 at Mofid Children’s Hospital.
Results: Offourty six patients 32 (70%) were boys and 14 (30%) were girls with ages ranging from 2 to 14 years. Surgical exploration was carried out in all cases, the lesions were located in the small intestine (N=17), large intestine (N=15), ileocecal region (N=12), and stomach (N=2). We performed a complete mass resection in 16 cases, debulking in 10 and lymph node/mass biopsy in 20 cases. Pathologic examination revealed Burkitt’s lymphoma for all patients. The majority were stageIIE and stage IIIE (24 and 19 respectively). Post-operative complications were seen in five cases with the most common being persistent ileus. All patients received a sort of systemic chemotherapy. The mean follow up duration was 6 years. Death occurred in 7(15%) of our patients, due to tumor lysis syndrome and acute renal failure.
Conclusion: The extent ofdisease at presentation is the most important prognostic factor in abdominal Burkitt’s lymphoma. Children with BL are at a high risk of tumor lysis syndrome before or during chemotherapy. Surgery still plays an important role in this pathology, and chemotherapy offers an excellent chance for long term disease free survival.
- Burkitt’s lymphoma
Cheng Fwt, Xiao J, Li CK: Management of tumor lysis syndrome in non-Hodgkin lymphoma. HK J Paediat (new series) 2009;14:11-15.
Harris NL, Jaffe ES, Diebold J, et al: World Health Organization Classification of neoplastic disease of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting-Airlie House, Virgina, November 1997, J ClinOncol 1999; 17:3835-49.
Cairo MS, Raetz E, Lim MS, et al: Childhood and adolescent non-Hodgkin lymphoma: new insights in biology and critical challenges for the future.Pediat Blood Cancer 2005; 45:753-69.
Suhag V , Sanita BS, Singh S, et al: Ileocaecal Burkitt’s Lymphoma in a 14 year old male. Pak J MedSci January-March 2005; 21:178-81.
Rao J, Lee KC, Chan L, et al: Advanced Burkitt’s Lymphoma Presenting with Jejunal Perforation. Ann Acad Med Singapore 2008; 37(3): 249-50.
Berard C, O'Connor GT, Thomas LB, et al: Surgery for Burkitt's lymphoma in children, bull WHO 40:601-607, 1969.
Skinner MA, Plumley DA, Grosfeld JL: Gatrointestinal tumors in children; an analysis of 39 cases. Ann Surg Oncol 1994; 1(4):283-289.
Attarbaschi A, Mann G, Ritr A: The role of surgery in the treatment of pediatric B-cell Non-Hodgkin’s lymphoma. J Ped Surg 2002; 37(10):70-1475.
Magrath IT: Malignant Non-Hodgkin’s lymphoma in children. In: Principles and Practice of Pediatric Oncology. Pizzo P A, Poplak D G.4th edition. Philadelphia: Lippincott Williams &Wilkins 2002, 661-705.
Laquaglia M, Stolar C, Krailo M: The role of surgery in abdominal NHL: Experience from the children cancer study group. Journal of Pediatric Surgery 1992; 27(2):230-235.
Lymphoma, Non-Hodgkin’s, childhood: Treatment-Health Professional information[NICPDO].http://health.yahoo.com/lymphomatreatment/lymphoma-non-hodgkin-s-childhood-tre…..2010/01/13.
Morsi A, Abdel-ghani M, El-shafiey M, et al: Clinico-pathological features and outcome of management of pediatric gastrointestinal lymphoma. Journal of the Egyptian Nat. Cancer Inst 2005; 17(4): 251-259.
Geramizadeh B, Azizi A, Kumar PV, et al: Value of Fine Needle Aspiration in diagnosing abdominal and retroperitoneal masses of children. Medical Journal of the Islamic Republic of Iran (MJIRI) 2004; 18(1): 29-33.
Patte C, Auperin A, MichonJ,et al: The Societe Francaisd’Oncologie Pediatrique LMB 89 protocol: Highly effective multiagent chemotherapy tailord to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia. Blood 2001; 97: 3370-79.
Hoxha FT, Hashani SI, Krasniqi AS, et al: Intussusceptions as acute abdomen caused by Burkitt lymphoma: a case report. Cases Journal 2009; 2:932
- Abstract Viewed: 278 times
- PDF Downloaded: 446 times