Iranian Journal of Pediatric Surgery

Vol. 12 No. 1 (2026)

A Comparison of Postoperative Delirium in Children Undergoing Elective Herniorrhaphy Following General Anesthesia with Sevoflurane and Isoflurane

Iranian Journal of Pediatric Surgery, Vol. 12 No. 1 (2026), 20 May 2026 , Page 10-24
https://doi.org/10.22037/irjps.v12i1.50761

Abstract

Abstract

Introduction: Postoperative delirium and agitation is a distressing event that occurs in most children. This study aimed to compare of postoperative delirium in children undergoing elective herniorrhaphy following general anesthesia by sevoflurane and isoflurane.

Materials and Methods: In this double-blind randomized clinical trial, 50 children aged 2 to 6 years; candidates for inguinal herniorrhaphy were divided into two groups of general anesthesia induced by sevoflurane and isoflurane. Anesthesia was induced by administering 5-7 mg / kg sodium thiopental and 0.5 mg / kg atracurium. They were monitored every 10 minutes to 30 minutes for postoperative delirium (POD) using Pediatric Anesthesia Emergence Delirium (PAED) scale.

Results:  The POD frequency was in the isoflurane and sevoflurane groups 1 (4%) and 18 (72%), respectively and this difference was significant between two groups (P=0.001). According to PAED, the POD severity in isoflurane group was less than sevoflurane group at minute 10 (P = 0.001). Also, there was a significant difference between the two groups in terms of POD severity at minute 20 (P= 0.001). The highest POD severity was seen in the isoflurane group at minute 30 (P =0.001).

  

Conclusion:     The results of the present study showed that the use of sevoflurane in the anesthesia maintenance phase for children less than 6 years of age leads to higher POD incidence as compared to isoflurane

Keywords:
  • Sevoflurane
  • Isoflurane
  • Agitation
  • Delirium
  • Herniorrhaphy
  • General anesthesia

How to Cite

Karami, N., Karami, T., & Aghazadeh, P. (2026). A Comparison of Postoperative Delirium in Children Undergoing Elective Herniorrhaphy Following General Anesthesia with Sevoflurane and Isoflurane. Iranian Journal of Pediatric Surgery, 12(1), 10–24. https://doi.org/10.22037/irjps.v12i1.50761

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