Age Distribution and Demographic Characteristics of Triple-Negative Breast Cancer Patients in Iran
Researcher Bulletin of Medical Sciences,
Vol. 30 No. 1 (2025),
20 Khordad 2026
,
Page e13
Abstract
Objective: Breast cancer remains the leading cause of cancer-related deaths among women worldwide. Researchers classify Triple-Negative Breast Cancer (TNBC) by the absence of oestrogen receptor (ER), progesterone receptor (PR), and HER-2 expression. This subtype accounts for 10–15% of breast cancer cases and shows poorer prognosis with higher recurrence rates compared to other forms. This study investigates the age distribution and demographic characteristics of TNBC patients in Iran.
Materials and Methods: Researchers collected data from TNBC patients who referred to Shohada Tajrish Hospital in Tehran over six years. They recorded clinical and demographic information and conducted statistical analyses using SPSS version 26.
Results: The study revealed that the average age of TNBC patients was 44.6 years, with most cases presenting invasive ductal carcinoma (IDC). Researchers noted that breast-conserving surgeries were the predominant treatment strategy.
Conclusion: TNBC in Iran aligns with global patterns, highlighting the higher prevalence of this subtype among younger age groups. Findings emphasize the importance of targeted approaches for early diagnosis and effective management.
- Breast cancer;, Triple-negative breast cancer; Estrogen receptor; HER-2 receptor;Progesterone receptor
How to Cite
References
1. Garrido-Castro, A. C., Lin, N. U., & Polyak, K. (2019). Insights into molecular classifications of triple-negative breast cancer: Improving patient selection for treatment. Cancer Discovery, 9(2), 176–198.
2. Siegel, R. L., Miller, K. D., & Jemal, A. (2021). Cancer statistics, 2021. CA: A Cancer Journal for Clinicians, 71(1), 7–33.
3. Sung, H., Ferlay, J., Siegel, R. L., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.
4. Yadav, B. S., Sharma, S. C., & Chanana, P. (2020). Systemic treatment strategies for triple-negative breast cancer. World Journal of Clinical Oncology, 11(5), 347–356.
- Abstract Viewed: 10 times