Investigating the association between metabolic syndrome components in the first trimester of pregnancy with gestational diabetes occurrence
Researcher Bulletin of Medical Sciences,
Vol. 29 No. 1 (2024),
4 January 2025
,
Page e2
Abstract
Objective: Given the high prevalence of metabolic syndrome and GDM in pregnancy and their impacts on maternal and newborn outcomes, this study was performed to assess the relationship between the components of metabolic syndrome in the first trimester with gestational diabetes occurrence.
Materials and Methods: A fasting blood sample was obtained for measuring fasting blood sugar (FBS) triglyceride (TG) and High-Density Lipoprotein (HDL) levels. If the mother had 3 or more of the following criteria, they were considered as having gestational metabolic syndrome (GMS). 1-Pre-pregnancy BMI≥Kg/m2 2- FBS≥100 mg/dl, 3- TG≥150 mg/dl,4-HDL<50 mg/dl,5-BP≥130/85 mm/Hg.
Results: Gestational diabetes occurred in 78 participants (15% of mothers). The results showed that metabolic syndrome itself (p-value: 0.022) and high triglyceride and FBS levels (p-values <0.001 both) had significant relationships with the occurrence of gestational diabetes. Logistic regression analysis showed increasing maternal age (OR:1.065, p-value: 0.046) and a history of gestational diabetes in previous pregnancies (OR: 6.562, p-value: 0.010) were significantly related to the occurrence of GD.
Conclusion: It was observed in this study that among the components of metabolic syndrome, high levels of blood sugar, and triglycerides in the first trimester of pregnancy were associated with the occurrence of gestational diabetes.
- Pregnancy; Metabolic syndrome; Lipid profile, Fasting blood sugar; Gestational diabetes.
How to Cite
References
-American Diabetes Association (2004) Gestational diabetes mellitus. Diabetes Care 27 Suppl 1: S88–S90 [PubMed]. [Journal]
-Schneider S, Bock C, Wetzel M, Maul H, Loerbroks A (2012) The prevalence of gestational diabetes in advanced economies. J Perinat Med 40: 511–520 [PubMed]. [Journal]
-World Health Organization. WHO Recommended Surveillance Standards. Second Edition. Published 1999. Accessed January 15, 2012. [Journal]
-Malcolm J (2012) Through the looking glass: gestational diabetes as a predictor of maternal and offspring long-term health. Diabetes Metab Res Rev 28: 307–311 [PubMed]. [Journal]
- Yessoufou A, Moutairou K (2011) Maternal diabetes in pregnancy: early and long-term outcomes on the offspring and the concept of “metabolic memory”. Exp Diabetes Res 2011: 218598. [PMC free article] [PubMed] . [Journal]
-American Diabetes Association (2011) Standards of medical care in diabetes: S11–S61 Diabetes Care 2011) 34 Suppl S11–S61 [PMC free article] [Journal])
-Balkau B, Valensi P, Eschwege E, Slama G (2007) A review of the metabolic syndrome. Diabetes Metab 33: 405–413 [PubMed]. [Journal]
-Grundy SM (2008) Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 28: 629–636 [PubMed]. [Journal]
-Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339(4):229–34. [Journal]
-Vanhala MJ, Kumpusalo EA, Pitkäjärvi TK, Takala JK. Metabolic syndrome in a middle-aged finnish population. J Cardiovasc Risk. 1997;4(4):291–5. [Journal]
-Kriska A, Delahanty L, Edelstein S, Amodei N, Chadwick J, et al. (2013) Sedentary behavior and physical activity in youth with recent onset of type 2 diabetes. Pediatrics 131: e850–e856 [PMC free article] [PubMed]. [Journal]
- Edwardson CL, Gorely T, Davies MJ, Gray LJ, Khunti K, et al. (2012) Association of sedentary behaviour with metabolic syndrome: a meta-analysis. PLoS One 7: e34916. [PMC free article] [PubMed]. [Journal]
- Pereira MA, Kottke TE, Jordan C, O'Connor PJ, Pronk NP, et al. (2009) Preventing and managing cardiometabolic risk: the logic for intervention. Int J Environ Res Public Health 6: 2568–2584 [PMC free article] [PubMed]. [Journal]
-Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, et al. Cardiovascular morbidity, and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24(4):683–9. [Journal]
-Gobl CS, Bozkurt L, Yarragudi R, Prikoszovich T, Tura A, Pacini G, et al. Biomarkers of endothelial dysfunction in relation to impaired carbohydrate metabolism following pregnancy with gestational diabetes mellitus. Cardiovasc Diabetol. 2014;13(1):138.
[Journal]
-. Kayem G, Miailhe G, Girard G, Legardeur H, Mandelbrot L, Selective rather than universal screening for gestational diabetes mellitus?2015 Aug;191:95-100. [Journal]
-Zahedian. R, Tavasoly .A, Abu Ali Zadeh. F, Ali Takhshid( the correlation with blood glucose levels in diabetic pregnancy serum levels of adenosine deaminase), 2014. [Journal]
- Jin WY, Lin SL, Hou RL, Chen XY, Han T, Jin Y, Tang L, Zhu ZW, Zhao ZY, Associations between maternal lipid profile and pregnancy complications and perinatal outcomes: a population-based study from China.2012. [Journal]
- Madhavan A, A pilot study on the usefulness of body mass index and waist hip ratio as a predictive tool for gestational diabetes in Asian Indians, 26 May 2008, 701-707. [Journal]
- Mannisto T, Mendola P, Vaarasmaki M, Jarvelin M, Hartikainen A, Pouta A, Suvanto E, Elevated Blood Pressure in Pregnancy and Subsequent Chronic Disease RiskClinical Perspective, 2013;127:681-690. [Journal]
-Eatamady. A, Saadat. N, Pezashc.P, Mirbolook .M, Azizi. F, (metabolic syndrome and development of diabetes and impaired glucose tolerance), 1383, Volume (6 1): 47-54. [Journal]
- Abstract Viewed: 225 times