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Vol. 24 No. 1 (2019)

Cholecystectomy: Long term effect on serum lipid profile and Vitamin D

  • Mohammad Fathi
  • Mohsen Soori
  • Fariborz Rashnoo
  • Esmaeil Hajinasrollah

Researcher Bulletin of Medical Sciences, Vol. 24 No. 1 (2019), , Page e9
Published 6 September 2020

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Abstract

Background: The association between cholecystectomy and abnormal lipids and later increase in the risk of diseases related to dyslipidemia showed controversial results. This study aims to evaluate the association of lipid profile and Vitamin D level before and after cholecystectomy.


Materials and Methods: Ninety-eight patients with symptomatic gallstones were studied prospectively. Plasma concentration of cholesterol, triglycerides, LDL, HDL and vitamin D was analyzed preoperatively and postoperatively after six months of cholecystectomy. None of the patients received any lipid-lowering drug or dietary restriction.


Results: Sixty-seven (68.4%) female and 31 (31.6%) male patients were studied for six months. There was a significant increase in total serum cholesterol besides a significant decrease in vitamin D and HDL serum level after six months. Also, there was a non-significant increase in the serum level of LDL and triglyceride. In stone based sub analysis the same results achieved.


Conclusion: There was a significant decrease in plasma concentration of vitamin D and HDL and the significant increase in cholesterol , triglyceride, and LDL in cholecystectomy patients postoperatively. These changes in plasma lipids and Vitamin D are likely to have a significant effect on the development of different disease related to dyslipidemia such as coronary artery disease and low bone density after cholecystectomy in the long term.


 

Keywords:
  • Cholesterol; Cholecystectomy; Triglycerides; vitamin D
  • e9

How to Cite

Fathi , M., Soori , M., Rashnoo , F., & Hajinasrollah , E. (2020). Cholecystectomy: Long term effect on serum lipid profile and Vitamin D . Researcher Bulletin of Medical Sciences, 24(1), e9. Retrieved from https://journals.sbmu.ac.ir/index.php/rbms/article/view/32162
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References

1. Sandler RS, Everhart JE, Donowitz M, Adams E, Cronin K, Goodman C, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122(5):1500-11.
2. Batajoo H, Hazra NK. Analysis of serum lipid profile in cholelithiasis patients. Journal of Nepal Health Research Council. 2013;11(23):53-5.
3. Jaraari AM, Jagannadharao P, Patil TN, Hai A, Awamy HA, El Saeity SO, et al. Quantitative analysis of gallstones in Libyan patients. The Libyan journal of medicine. 2010;5:10.4176/091020.
4. Peela J, Jarari A, El Awami H, Patil T. Lipid Profile in Bile and Serum of Cholelithiasis Patients--A Comparative Study2012.
5. A.H. Jawad NAA, I.J. Al-Assadi. Action of cholecystectomy and the alcoholic extract of Taraxacum officinal leaves on plasma lipid profile in rabbits. Journal of Basrah Researches (Sciences). 2006;32(1):7.
6. Zhao J-C, Xiao L-J, Zhu H, Shu Y, Cheng N-S. Changes of lipid metabolism in plasma, liver and bile during cholesterol gallstone formation in rabbit model. World journal of gastroenterology. 1998;4(4):337-9.
7. Moazeni bistgani M, Kheiri S, Ghorbanpour K. The effects of cholecystectomy on serum lipids during one year follow-up2014.
8. Zhao J, Xiao L, Zhu H, Shu Y, Cheng N. [Change of serum lipid, apolipoprotein during cholesterol gallstone formation in rabbit model]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. 1997;28(4):361-4.
9. Malik AA, Wani ML, Tak SI, Irshad I, Ul-Hassan N. Association of dyslipidaemia with cholilithiasis and effect of cholecystectomy on the same. International journal of surgery (London, England). 2011;9(8):641-2.
10. Gill GS, Gupta K. Pre- and Post-operative Comparative Analysis of Serum Lipid Profile in Patients with Cholelithiasis. International journal of applied & basic medical research. 2017;7(3):186-8.
11. Juvonen T, Kervinen K, I Kairaluoma M, Kesaniemi A. Effect of cholecystectomy on plasma lipid and lipoprotein levels1995. 377-82 p.
12. Walmsley MJ, Waddecar J, Schofield PF. Serial serum cholesterol estimations after biliary-tract surgery. 1970;57(11):829-31.
13. Polat HB, Beyazal MS. The effect of cholecystectomy on 25-hydroxyvitamin D levels and bone mineral density in postmenopausal women. Archives of osteoporosis. 2018;13(1):61.
14. Stoker GE, Buchowski JM, Stoker ME. Prior Cholecystectomy as a Predictor of Preoperative Vitamin D Deficiency in Adults Undergoing Spine Surgery. Archives of Surgery. 2012;147(6):577-8.
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