The Genetic Causes of Male Infertility in Iranian Population; A systematic Review
Men's Health Journal,
Vol. 2 No. 1 (2018),
13 July 2018
Introduction: Infertility affects an estimated 15% of couples globally and in Iran, a quarter of couples experiences primary infertility. Males are found to be individually responsible for 20-30% of infertility cases and contribute to 50% of cases totally. When assisted reproductive technologies (ARTs) are used to acquire pregnancy, a sufficient (epi) genetic diagnosis of male infertility (MI) is of main matter to consider if a genetic abnormality will be transmit-ted to offspring. Infertility centers together with Infertility research centers had been founded since 1994 in Iran and many articles from research projects have been published.
Materials and Methods: This literature investigated the possible genetic causes mechanisms underlying Iranian male infertility by extensive article searches. First, we reviewed available data from the Google Scholar, PubMed, Scopus, Web of Science, IranMedex, MEDLIB, IranDoc and Scientific Information Database were searched for articles published until 2018, using the MeSH terms for a variety of chromosome abnormalities, Y-chromosome microdeletions, gene mutations, expression and polymorphisms, Male infertility and/or Iranian, regional and international population, to provides the evidence- based and a comprehensive, up-to- date evaluation of the multifactorial factors involved in Iranian infertile men.
Results: According to the strategy adopted initially, 274 manuscripts were found. After reviewing the titles, abstracts and manuscripts entirely cited, the total of 139 articles were obtained and selected according to the eligibility criteria. The 139 studies were divided into four predetermined categories that mentioned above. Studies have good methodological validity. The sample is quite heterogeneous, given the very different design of the studies.
Conclusion: MI is a complex, multi-factorial disease and the underlying reasons frequently remain unknown. It seems that the first line of genetic diagnosis in Iranian male infertility is similar to Global One. In all investigations conducted in Iran, there are vacancies in studies such as epigenetic modification studies, RNA (lncRNA, miRNA and piRNA) abnormalities, mutation detection and polymorphism studies in other genes involved in the spermatogenesis process. At present, we have a little information for some polymorphisms (MTHFR, GST, ER, and DAZL) and mutations (mtDNA, CATSPER) which require more extensive studies. Such articles help to find a better insight into the causes of infertility in the Iranian men's community and will provide valuable visions into the development of targeted personalized treatments for patients and the ascertainment of the reasons of idiopathic infertility.
How to Cite
Tahmasbpour E, Balasubramanian D, Agarwal A. A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART). J Assist Reprod Genet. 2014 Sep;31(9):1115-37.
Vahidi s., Ardalan A., Kazem M., Prevalence of primary infertility in the Islamic Republic of Iran in 83-84, Fertility and Infertility Quarterly / Fall 1385 pages 243-251.
Azimi C., Khaleghian F., Farzanfar F., Cytogenetic studies among Iranian infertile men: The first 20-year long-term report, African Journal of Biotechnology Vol. 11(37), pp. 8973-8978, 8 May, 2012.
Jungwirth A., Diemer T., Dohle G.R, Giwercman A., Kopa Z., Krausz C., Tournaye H.,Guidelines on Male Infertility European Association of Urology 2015.
Akbari MT, Behjati F, Pourmand GR, Asbagh FA, Kachoui MA. Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran:Report and review. Indian J Hum Genet. 2012 May; 18 (2):198-203.
Monabati A., Rekabi V., Noori S., Safaei A., Cytogenetic Analysis in Infertile Male Patients with Oligospermia and Azoospermia in the Southern Region of Iran, Shiraz, Journal of Cancer Prevention & Current Research,2016.
Mahjoubi F,Saeideh S, Sanaz M. Chromosomal abnormalities in infertile men referred to iran blood transfusion organization research center. J Reprod Infertil. 2010 Oct;11(3):175-8.
Salahshourifar I., Sadighi Gilani MA., Masoudi N., Gourabi H., Chromosomal Abnormalities in Iranian Infertile Men who are Candidates for Assisted Reproductive Techniques, Iranian Journal of Fertility and Sterility, 2007.
Mozdarani H, Meybodi AM, Zari-Moradi S. A cytogenetic study of couples with recurrent spontaneous abortions and infertile patients with recurrent IVF/ICSI failure. Indian J Hum Genet. 2008 Jan;14(1):1-6.
Shaveisi-Zadeh F., Davarian K., Movafagh A., Mirfakhraie R.,et al., Cytogenetic Abnormalities and Y Chromosome Microdeletions in Azoospermic and Oligospermic Infertile Males from West of Iran, Journal of Paramedical Sciences (JPS),2017.
Totonchi M, Mohseni Meybodi A, Borjian Boroujeni P, Sedighi Gilani M, Almadani N, Gourabi Clinical data for 185 infertile Iranian men with Y-chromosome microdeletion. J Assist Reprod Genet. 2012;29(8):847–53.
Pouriamanesh S, Kamalian Z, Shafaat P, Amin Bidokhti M, Salsabili N, Mirfakhraei R. Analysis of Y Chromosome Microdeletions and Mutation in Exon7 of the STAG3 Gene in Iranian Infertile Men with Idiopathic Non-Obstructive Azoospermia. amuj. 2016; 19 (6) :19-26.
Masoudi R, Mazaheri-Asadi L, Khorasani S. Partial and complete microdeletions of Y chromosome in infertile males from South of Iran. Mol Biol Res Commun. 2016 Dec;5(4):247-255.
Saliminejad K, Sadeghi MR, Kamali K, Amirjannati N, Soltanghoraee H, Khorram Khorshid HR. Discrepancy in the frequency of Y chromosome microdeletions among Iranian infertile men with azoospermia and severe oligozoospermia. Genet Test Mol Biomarkers. 2012;16(8):931–4.
Asadi F, Sadighi Gilani MA, Ghaheri A, Roodgar Saffari J, Zamanian M. The Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia. Cell J. 2017 Apr-Jun;19(1):27-33.
Zaimy MA, Kalantar SM, Sheikhha MH, Jahaninejad T, Pashaiefar H, Ghasemzadeh J, et al. The frequency of Yq microdeletion in azoospermic and oligospermic Iranian infertile men. Iran J Reprod Med. 2013;11(6):453–8.
Malekasgar AM, Mombaini H. Screening of ‘Y’ chromosome microdeletions in Iranian infertile males. J Hum Reprod Sci. 2008;1(1):2–9.
Omrani MD, Samadzadae S, Bagheri M, Attar K. Y chromosome microdeletions in idiopathic infertile men from West Azarbaijan. Urol J. 2006;3(1): 38–43.
Mirfakhraie R, Mirzajani F, Kalantar SM, Montazeri M, Salsabili N, PourmandGR, Houshmand M. High prevalence of AZFb microdeletion in Iranian patients with idiopathic non-obstructive azoospermia. Indian J Med Res. 2010 Sep;132:265-70.
Heidari S, Hojati Z, Motovali-Bashi M. Screening of Two Neighboring CFTR Mutations in Iranian Infertile Men with Non-Obstructive Azoospermia. Int J Fertil Steril. 2017 Jan-Mar;10(4):390-394.
Safinejad K, Darbouy M, Kalantar SM, Zeinali S, Mirfakhraie R, Yadegar L,Houshmand M. The prevalence of common CFTR mutations in Iranian infertile men with non-CAVD obstructive azoospermia by using ARMS PCR techniques. J Assist Reprod Genet. 2011 Nov;28(11):1087-90.
Radpour R, Gourabi H, Dizaj AV, Holzgreve W, Zhong XY. Genetic investigations of CFTR mutations in congenital absence of vas deferens, uterus, and vagina as a cause of infertility. J Androl. 2008 Sep-Oct;29(5):506-13.
Ferlin A, Raicu F, Gatta V, Zuccarello D, Palka G, Foresta C. Male infertility: role of genetic background. Reprod Biomed Online. 2007,Jun;14(6):734-45.
Zhou H, Zhu JW, Li HG, Tang YP. Genetic defect in Chinese azoospermic patients and their relationship with reproductive hormones. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Aug;26(4):427-30.
Gündüz G, Lüleci G, Baykara M. Cytogenetic study in 102 infertile men. Urol Int. 1998;61(1):32- 4.
Mahjoubi F, Razazian F. Constitutional complex chromosomal rearrangements in a klinefelter patient: case report and review of literature. J Assist Reprod Genet.2012 May;29(5):437-41.
Sabbaghian M, Modarresi T, Hosseinifar H, Hosseini J, Farrahi F, Dadkhah F, Chehrazi M, Khalili G, Sadighi Gilani MA. Comparison of sperm retrieval and intracytoplasmic sperm injection outcome in patients with and without Klinefelter syndrome. Urology. 2014 Jan;83(1):107-10.
Ghoraeian P, Mozdarani H, Aleyasin A, Alizadeh-Nili H. Frequency of sex chromosomal disomy in spermatozoa of normal and oligozoospermic Iranian patients and its effects on fertilisation and implantation rates after ICSI. Andrologia.2013 Feb;45(1):46-55.
Borjian Boroujeni P, Sabbaghian M, Vosough Dizaji A, Zarei Moradi S, Almadani N, Mohammadpour Lashkari F, Zamanian MR, Mohseni Meybodi A. Clinical aspects of infertile 47,XYY patients: a retrospective study. Hum Fertil (Camb). 2017 Jul 18:1-6.
Mohammadpour Lashkari F, Totonchi M, Zamanian MR, Mansouri Z, Sadighi Gilani MA, Sabbaghian M, Mohseni Meybodi A. 46,XX males: a case series based on clinical and genetics evaluation. Andrologia. 2017 Sep;49(7).
Mohammadpour Lashkari F, Sadighi Gilani MA, Ghaheri A, Zamanian MR, Borjian Boroujeni P, Mohseni Meybodi A, Sabbaghian M. Clinical aspects of 49 infertile males with 45,X/46,XY mosaicism karyotype: A case series. Andrologia. 2018 Mar 12.
Oliver-Bonet M, Ko E, Martin RH. Male infertility in reciprocal translocation carriers: the sex body affair. Cytogenet Genome Res. 2005;111(3-4):343-6. Review.
Krausz C, Hoefsloot L, Simoni M, Tüttelmann F; European Academy of Andrology; European Molecular Genetics Quality Network. EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013.
Yousefi-Razin E, Nasiri MJ, Omrani MD. Frequency of Y Chromosome Microdeletions Among Iranian Infertile Men with Azoospermia and Severe Oligozoospermia: A Meta-analysis. J Reprod Infertil. 2016 Oct-Dec;17(4):208-212.
Nowroozi M., Radkhah K., Ranjbaran A.R., Ghaffari S.R., Sedighi Gilani M.A., Gourabi H., Is karyotyping and Y chromosome microdeletion study necessary in men candidate for ICSI ? Iranian Journal of Reproductive Medicine Vol.8. No. 4 . pp: 173 - 178 , Autumn 2010.
Tehraninejad ES, Pourmatroud E, Sadighi Gilani MA, Rakebi M, Azimi Neko Z, Arabipoor A. Comparison of Intracytoplasmic Sperm Injection Outcomes between Oligozoospermic, Obstructive Azoospermic and Non-Obstructive Azoospermic Patients. Int J Fertil Steril. 2012 Apr;6(1):13-8.
Kalankesh LR, Dastgiri S, Rafeey M, Rasouli N, Vahedi L. Minimum data set for cystic fibrosis registry: a case study in iran. Acta Inform Med. 2015 Feb;23(1):18-21.
Alibakhshi R, Kianishirazi R, Cassiman JJ, Zamani M, Cuppens H. Analysis of the CFTR gene in Iranian cystic fibrosis patients: identification of eight novel mutations. J Cyst Fibros. 2008 Mar;7(2):102-9.
Sharma H, Mavuduru RS, Singh SK, Prasad R. Increased frequency of CFTR genemutations identified in Indian infertile men with non-CBAVD obstructive azoospermia and spermatogenic failure. Gene. 2014 Sep 10;548(1):43-7.
Khatami SR., Galehdari H., Rasekh A., Mombeini H., Konar E.,Assessment of Correlation between Androgen Receptor CAG Repeat Length and Infertility in Infertile Men Living in Khuzestan, Iran, Int J Fertil Steril. 2015 Jul-Sep; 9(2): 189–196.
Mirfakhraie R, Kalantar SM, Mirzajani F, Montazeri M, Salsabili N, Houshmand M, Hashemi-Gorji F, Pourmand G. A novel mutation in the transactivation-regulating domain of the androgen receptor in a patient with azoospermia. J Androl. 2011 Jul-Aug;32(4):367-70.
Ahmadzadeh A, Ghods E, Mojarrad M, Aboutorabi R, Afkhamizadeh M, Bonakdaran S,Mosavi Z, Taghavi SM, Hassanzadeh Nazarabadi M. Study on KAL1 Gene Mutations in Idiopathic Hypogonadotropic Hypogonadism Patients with X-Linked Recessive Inheritance. Int J Mol Cell Med. 2015 Summer;4(3):152-9.
Talebi E, Karimian M, Nikzad H. Association of sperm mitochondrial DNA deletions with male infertility in an Iranian population. Mitochondrial DNA A DNA Mapp Seq Anal. 2017 May 24:1-9.
Bahrehmand Namaghi I, Vaziri H. Sperm mitochondrial DNA deletion in Iranian infertiles with asthenozoospermia. Andrologia. 2017 Apr;49(3).
Gashti NG, Salehi Z, Madani AH, Dalivandan ST. 4977-bp mitochondrial DNA deletion in infertile patients with varicocele. Andrologia. 2014 Apr;46(3):258-62.
Amiri-Yekta A, Coutton C, Kherraf ZE, Karaouzène T, Le Tanno P, Sanati MH, Sabbaghian M, Almadani N, Sadighi Gilani MA, Hosseini SH, Bahrami S, Daneshipour A, Bini M, Arnoult C, Colombo R, Gourabi H, Ray PF. Whole-exome sequencing of familial cases of multiple morphological abnormalities of the sperm flagella (MMAF) reveals new DNAH1 mutations. Hum Reprod. 2016 Dec;31(12):2872-2880.
Alimardanian L, Saliminejad K, Razi S, Ahani A. Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia. Andrologia. 2016 Nov;48(9):890-894.
Hosseinifar H, Shafipour M, Modarresi T, Azad M, Sadighi Gilani MA, Shahhosseini M, Sabbaghian M. Relationship between absence of annulus and asthenozoospermia in Iranian men. J Assist Reprod Genet. 2014 Dec;31(12):1681-5.
Zare-Abdollahi D, Safari S, Mirfakhraie R, Movafagh A, Bastami M, Azimzadeh P,Salsabili N, Ebrahimizadeh W, Salami S, Omrani MD. Mutational screening of the NR5A1 in azoospermia. Andrologia. 2015 May;47(4):395-401.
Jamshidi J, Pouresmaeili F, Darvish H, Omrani MD, Azargashb E, Sadeghi MR, Lakpour N. FABP9 Mutations Are Not Detected in Cases of Infertility due to Sperm Morphological Defects in Iranian Men. Int J Fertil Steril. 2014 Jan;7(4):275-80.
Hildebrand MS, Avenarius MR, Fellous M, Zhang Y, Meyer NC, Auer J, Serres C, Kahrizi K, Najmabadi H, Beckmann JS, Smith RJ. Genetic male infertility and mutation of CATSPER ion channels. Eur J Hum Genet. 2010 Nov;18(11):1178-84.
Avenarius MR, Hildebrand MS, Zhang Y, Meyer NC, Smith LL, Kahrizi K, Najmabadi H, Smith RJ. Human male infertility caused by mutations in the CATSPER1 channel protein. Am J Hum Genet. 2009 Apr;84(4):505-10.
Omrani MD., Nordenskhold A., Mutation detection in human estrogen receptor β gene in infertile male patients by denaturing high-performance liquid chromatography, Iranian Journal of Reproductive Medicine Vol.3. No.1 pp: 9-13, 2005.
Khazamipour N, Noruzinia M, Fatehmanesh P, Keyhanee M, Pujol P. MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility. Hum Reprod. 2009 Sep;24(9):2361-4.
Zhang Y, Malekpour M, Al-Madani N, Kahrizi K, Zanganeh M, Mohseni M, Mojahedi F, Daneshi A, Najmabadi H, Smith RJ. Sensorineural deafness and male infertility:a contiguous gene deletion syndrome. BMJ Case Rep. 2009;2009.
Asadpor U, Totonchi M, Sabbaghian M, Hoseinifar H, Akhound MR, Zari Moradi Sh, Haratian K, Sadighi Gilani MA, Gourabi H, Mohseni Meybodi A. Ubiquitin-specific protease (USP26) gene alterations associated with male infertility and recurrent pregnancy loss (RPL) in Iranian infertile patients. J Assist Reprod Genet. 2013 Jul;30(7):923-31.
Nili HA, Mozdarani H, Aleyasin A. Correlation of sperm DNA damage with protamine deficiency in Iranian subfertile men. Reprod Biomed Online. 2009 Apr;18(4):479-85.
Stouffs K, Seneca S, Lissens W. Genetic causes of male infertility. Ann Endocrinol (Paris). 2014 May;75(2):109-11.
Salsabili N., Mirfakhraei R., Montazeri M., Ataei M., Yaghmaei P., Pourmand Gh., Gonadotropin and Testosterone hormone’s serum levels and partial deletions in the AZFc region in Iranian oligozoospermia infertile males, Health 3 ,2011,566-570.
Sadeghi-Nejad H, Farrokhi F. Genetics of azoospermia: current knowledge,clinical implications, and future directions. Part II: Y chromosome microdeletions. Urol J. 2007 Fall;4(4):192-206.
Jones RJ, Tay GK, Mawart A, Alsafar H. Y-Chromosome haplotypes reveal relationships between populations of the Arabian Peninsula, North Africa and South Asia. Ann Hum Biol. 2017 Dec;44(8):738-746.
Nikzad H, Karimian M, Sareban K, Khoshsokhan M, Hosseinzadeh Colagar A.MTHFR-Ala222Val and male infertility: a study in Iranian men, an updated meta-analysis and an in silico-analysis. Reprod Biomed Online. 2015 Nov;31(5):668-80.
Momenzadeh M., Analysis of methylenetetrahydrofolate reductase (mthfr)c677t and a1298c polymorphisms on male infertility, Indian Journal of Fundamental and Applied Life Sciences,2016.
Rayegani M., Sadeghi M.R., Yaghmaei B., Akhoundi M.A., Lakpour N., Hojat M., Rezaei Farimani A, comparison of c677t polymorphism of the methylenetetrahydrofolate reductase (mthfr) gene in oligo-asthenoteratozoospermic (oat) and normozoospermic iranian men, International journal of reproductive biomedicine,2009.
Li SS, Li J.,MTHFR gene polymorphism and male infertility, Zhonghua Nan Ke Xue. 2010 Jan;16(1):60-4.
Karimian M, Colagar AH. Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility. Reprod Fertil Dev. 2016 Apr;28(6):785-94. doi: 10.1071/RD14186.
Hadiyan SP, Mashayekhi F, Salehi Z. The association between DAZ T > C polymorphism and idiopathic male infertility risk in north of Iran. Mol Biol (Mosk). 2015 Jan-Feb;49(1):190-2.
Nejati M and Karimian M., DAZL A386G gene mutation and male infertility: A genetic association analysis of Asian population, Biosci. Biotech. Res. Comm. 9(4): 850-855, 2016.
Moghadam M, Khatami SR, Galehdari H. Association of androgen receptor GGN repeat length polymorphism and male infertility in Khuzestan, Iran. Iran J Reprod Med. 2015 May;13(5):305-10.
Khatami SR, Galehdari H, Rasekh A, Mombeini H, Konar E. Assessment of Correlation between Androgen Receptor CAG Repeat Length and Infertility in Infertile Men Living in Khuzestan, Iran. Int J Fertil Steril. 2015 Jul-Sep;9(2):189-96.
Radpour R, Rezaee M, Tavasoly A, Solati S, Saleki A. Association of long polyglycine tracts (GGN repeats) in exon 1 of the androgen receptor gene with cryptorchidism and penile hypospadias in Iranian patients. J Androl. 2007;28:164–169.
Zare-Karizi Sh., Amin-Beidokhti M., Rahimi M., Mirfakhraie R., nalysis of the androgen receptor CAG repeats length in Iranian patients with idiopathic non-obstructive azoospermia, Asian Pacific Journal of Reproduction,2016.
Wallerand H, Chabannes E, Bittard H. [Idiopathic male infertility and androgen receptors]. Prog Urol. 2001 Sep;11(4):610-20.
Mostafa T, El-Shahid LH, El Azeem AA, Shaker O, Gomaa H, Abd El Hamid HM.Androgen receptor-CAG repeats in infertile Egyptian men. Andrologia. 2012 Jun;44(3):147-51. doi: 10.1111/j.1439-0272.2010.
Nenonen HA, Giwercman A, Hallengren E, Giwercman YL. Nonlinear association between androgen receptor CAG repeat length and risk of male subfertility–a meta-analysis. Int J Androl 2011;34(4): 327-332.
Heidari MM, Khatami M, Talebi AR. The POLG Gene Polymorphism in Iranian Varicocele-Associated Infertility Patients. Iran J Basic Med Sci. 2012,Mar;15(2):739-44.
Krausz C, Guarducci E, Becherini L, degl'Innocenti S, Gerace L, Balercia G, et al. The clinical significance of the POLG gene polymorphism in male infertility. J Clin Endocr Metab 2004 ; 89:4292-4297.
Aknin-Seifer IE, Touraine RL, Lejeune H, Jimenez C, Chouteau J, Siffroi JP, et al. Is the CAG repeat of mitochondrial DNA polymerase gamma (POLG) associated with male infertility? A multi-centre French study.Hum Reprod 2005; 20:736-740.
Safarinejad MR, Shafiei N, Safarinejad S. Association of polymorphisms in the estrogen receptors alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and semen parameters. J Steroid Biochem Mol Biol. 2010 Oct;122(4):193-203j.jsbmb.2010.06.011.
Omrani M.D., Samadzadae S., Farshid B.,Jahandidae B., Yazdanpanah K., Is There Any Association Between ERβ Gene Polymorphism and Infertility in Iranian Men?, JRMS 2006; 11(1): 48-52.
Yu-Zheng Ge, Lu-Wei Xu, Rui-Peng Jia,corresponding author Zheng Xu, Wen-Cheng Li, Ran Wu, Sheng Liao, Fei Gao, Si-Jia Tan, Qun Song, and Hui Xin, ssociation of polymorphisms in estrogen receptors (ESR1 and ESR2) with male infertility: a meta-analysis and systematic review, J Assist Reprod Genet. 2014.
Safarinejad M.R., Shafiei N. and Safarinejad S., Evaluating the role of the FSH receptor gene Thr 307-Ala and Asn 680 -Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones, BJU INTERNATIONAL ,2010.
Gharesi-Fard B., Ghasemi Z., Shakeri S., Behdin Sh., Aghaei F., Malek-Hosseini Z., The frequency of follicle stimulating hormone receptor gene polymorphisms in Iranian infertile men with azoospermia, Iran J Reprod Med. 2015 Nov; 13(11): 673–678.
Khazaie Y. and Nasr Esfahani M.H., MicroRNA and Male Infertility: A Potential for Diagnosis, Int J Fertil Steril. 2014 Jul-Sep; 8(2): 113–118.
Razavi S.M., Sabbaghian M., Jalili M., Divsalar A., Wolkenhauer O., Salehzadeh-Yazd A., Comprehensive functional enrichment analysis of male infertility, Sci Rep. 2017; 7: 15778.
Abhari A., Zarghami N., Shahnazi V., Barzegar A., Farzadi L., Karami H., Zununi Vahed S., Nouri M., Significance of microRNA targeted estrogen receptor in male fertility, Iran J Basic Med Sci. 2014 Feb; 17(2): 81–86.
Abhari A., Zarghami N., Farzadi L., Nouri M., Shahnazi V., Altered of microRNA expression level in oligospermic patients, Iran J Reprod Med. 2014 Oct; 12(10): 681–686.
Ghorbian S., Micro-RNAs, next-generation molecular markers in male infertility field, Transl Androl Urol. 2012 Dec; 1(4): 245–246.
Kamaliyan Z., Pouriamanesh S., Amin-beidokhti M., Rezagholizadeh A., Mirfakhraie R., HIWI2 rs508485 Polymorphism Is Associated with Non-obstructive Azoospermia in Iranian Patients, Rep Biochem Mol Biol. 2017 Apr; 5(2): 108–111.
Harchegani AB, Shafaghatian H, Tahmasbpour E, Shahriary A. Regulatory Functions of MicroRNAs in Male Reproductive Health: A New Approach to Understanding Male Infertility. Reprod Sci. 2018 Jan 1:1933719118765972.
Safarinejad M.R., Shafiei N. and Safarinejad S., The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility, Journal of Human Genetics (2010) 55, 565–570.
Ashrafzadeh HR, Nazari T, Dehghan Tezerjani M, Khademi Bami M, Ghasemi-Esmailabad S, Ghasemi N. Frequency of TNFR1 36 A/G gene polymorphism in azoospermic infertile men: A case-control study. Int J Reprod Biomed (Yazd). 2017 Aug;15(8):521-526.
Zamani-Badi T, Karimian M, Azami-Tameh A, Nikzad H. Association of C3953T transition in interleukin 1β gene with idiopathic male infertility in an Iranian population. Hum Fertil (Camb). 2017 Oct 3:1-7.
Asgari R, Mansouri K, Bakhtiari M, Bidmeshkipour A, Yari K, Shaveisi-Zadeh F, Vaisi-Raygani A. Association of FAS-670A/G and FASL-844C/T polymorphisms with idiopathic azoospermia in Western Iran. Eur J Obstet Gynecol Reprod Biol. 2017 Nov;218:55-59.
Aftabi Y, Hosseinzadeh Colagar A, Mehrnejad F, Seyedrezazadeh E, Moudi E. Aryl hydrocarbon receptor gene transitions (c.-742C>T; c.1661G>A) and idiopathic male infertility: a case-control study with in silico and meta-analysis. Environ Sci Pollut Res Int. 2017 Sep;24(25):20599-20615.
Jahantigh D, Hosseinzadeh Colagar A. XRCC5 VNTR, XRCC6 -61C>G, and XRCC7 6721G>T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case-Control and In Silico Studies. Int J Endocrinol. 2017;2017:4795076.
Rafatmanesh A, Nikzad H, Ebrahimi A, Karimian M, Zamani T. Association of the c.-9C>T and c.368A>G transitions in H2BFWT gene with male infertility in an Iranian population. Andrologia. 2017 Mar 30.
Siasi E, Aleyasin A. Four Single Nucleotide Polymorphisms in INSR, SLC6A14,TAS2R38, and OR2W3 Genes in Association with Idiopathic Infertility in Persian Men. J Reprod Med. 2016 Mar-Apr;61(3-4):145-52.
Najafipour R, Rashvand Z, Alizadeh A, Aleyasin A, Moghbelinejad S. Association of G/T(rs222859) polymorphism in Exon 1 of YBX2 gene with azoospermia, among Iranian infertile males. Andrologia. 2016 Nov;48(9):956-960. doi:10.1111/and.12537. Epub 2016 Jan 25.
Shahhoseini M, Azad M, Sabbaghian M, Shafipour M, Akhoond MR, Salman-Yazdi R, Sadighi Gilani MA, Gourabi H. New single nucleotide polymorphism G5508A in the SEPT12 gene may be associated with idiopathic male infertility in Iranian men.Iran J Reprod Med. 2015 Aug;13(8):503-6.
Haji Ebrahim Zargar H, Mohseni Meybodi A, Sabbaghian M, Shahhoseini M, Asadpor U, Sadighi Gilani MA, Chehrazi M, Farhangniya M, Shahzadeh Fazeli SA. Associationof Two Polymorphisms in H2B.W Gene with Azoospermia and Severe Oligozoospermia inAn Iranian Population. Int J Fertil Steril. 2015 Jul-Sep;9(2):205-14.
Zamani MR, Asbagh FA, Massoud AH, Salmaninejad A, Massoud A, Rezaei N. Association between a PD-1 gene polymorphism and antisperm antibody-relatedinfertility in Iranian men. J Assist Reprod Genet. 2015 Jan;32(1):103-doi:10.1007/s10815-014-0371-4. Epub 2014 Nov 16.
Lakpour N, Mirfeizollahi A, Farivar S, Akhondi MM, Hashemi SB, Amirjannati N, Heidari-Vala H, Sadeghi MR. The association of seminal plasma antioxidant levels and sperm chromatin status with genetic variants of GSTM1 and GSTP1 (Ile105Valand Ala114Val) in infertile men with oligoasthenoteratozoospermia. Dis Markers.2013;34(3):205-10.
Siasi E, Aleyasin A, Mowla J, Sahebkashaf H. Association study of six SNPs in PRM1, PRM2 and TNP2 genes in iranian infertile men with idiopathic azoospermia.Iran J Reprod Med. 2012 Jul;10(4):329-36.
Mashayekhi F, Hadiyan SP. A single-nucleotide polymorphism in TP53 may be a genetic risk factor for Iranian patients with idiopathic male infertility. Andrologia. 2012 May;44 Suppl 1:560-4.
Salehi Z, Gholizadeh L, Vaziri H, Madani AH. Analysis of GSTM1, GSTT1, and CYP1A1 in idiopathic male infertility. Reprod Sci. 2012 Jan;19(1):81-5.
Salamian a., Ghaedi k., Razavi Sh., Tavalaee m., Tanhaei S.,Tavalaee M., Salahshouri I., Gourabi H., Nasr-Esfahani M.H., Single Nucleotide Polymorphism Analysis of Protamine Genes in Infertile Men, International Journal of Fertility and Sterility Vol 2, No 1, May-Jun 2008.
Karimian M, Nikzad H, Azami-Tameh A, Taherian A, Darvishi FZ, Haghighatnia MJ. SPO11-C631T Gene Polymorphism: Association With Male Infertility and an in Silico-Analysis. J Family Reprod Health. 2015 Nov;9(4):155-63.
Roozbahani G., Sheidai M., Noormohammadi Z., Goorabi H., Association study of SPATA - 16 polymorphism with male infertility in Iranian population, mgene.2017.07.001.
Heidari M.,Sheidai M.,Noormohammadi Z.,Atri Roozbahani G., Kalhor N., Association study of TAF7L two SNPs with oligozoospermia patients, genrep.2017.10.004.
YadollahyKhaless A., Kalhor N., Atri Roozbahani G., Association between CPEB1 gene polymorphism and Iranian male infertility, JSSU. 2017; 25 (8) :612-620.
Sabouhi S, Salehi Z, Bahadori MH, Mahdavi M. Human catalase gene polymorphism (CAT C-262T) and risk of male infertility. Andrologia. 2015 Feb;47(1):97-101.
Mohagheghi A., Khodadadi I., r Karami M., Amiri I., Tavilani H., The Impact of G1575A Matrix Metalloprotease-2 Gene Polymorphism on Male Fertility, Avicenna J Med Biochem. 2015;3(1): e27826.
Poursharif A., H Vaziri H.R., Mirzapour T., Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility, Iran South Med J 2017, 20(3): 257-266.
Kohan L., Tabiee O., The Role of rs2227956 HSPA1L Gene Polymorphism in Idiopathic Male Infertility, J Fasa Univ Med Sci 2016, 6(2): 188-193.
Naghavi A., Fazeli F. , Salimi S., Nemati Mud B. Glutathione-S-transferase P1 Ile105Val polymorphism and idiopathic male infertility, Eur Urol Suppl 2013;12;e1133.
Majidi H., Kohan L., Rasekh A., Association between Mir-34 b/c rs4938723 Gene Polymorphism and the Risk of Male Infertility, sjimu 2017, 25(3): 83-89.
Ebrahimi M., Vaziri H.R., Bahadori MH., Ajamian F., Genetic variation of choline dehydrogenase gene in idiopathic male infertility, Progress in Biological Sciences,2014.
Sarkardeh H, Totonchi M, Asadpour O, Sadighi Gilani MA, Zamani Esteki M, Almadani N, Borjian Boroujeni P, Gourabi H. Association of MOV10L1 gene polymorphisms and male infertility in azoospermic men with complete maturation arrest. J Assist Reprod Genet. 2014 Jul;31(7):865-71.
Hosseini SH, Sadighi Gilani MA, Meybodi AM, Sabbaghian M. The impact of RABL2B gene (rs144944885) on human male infertility in patients with oligoasthenoteratozoospermia and immotile short tail sperm defects. J Assist Reprod Genet. 2017 Apr;34(4):505-510.
Rostami Chayjan M , Sabbaghian M , Alikhani M , Sahraneshin Samani F , Salman Yazdi R , Almadani N , Mohseni Meybodi A, Relation of β-defensin 126 gene (DEFB126) alteration and protein expression with unexplained male infertility in Iranian population Arak Medical University Journal (AMUJ)2014; 17(86): 31-40.
Jamalvandi M, Motovali-Bashi M, Amirmahani F, Darvishi P, Jamshidi Goharrizi K. Association of T/A polymorphism in miR-1302 binding site in CGA gene with male infertility in Isfahan population. Mol Biol Rep. 2018 Apr 7.
Moghbelinejad, S., Najafipour, R., Momeni, A. Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population, 2018, Genes and Genomics 40(1), pp. 17-24.
Lakpour N, Modarresi MH, Kharazi H, Akhondi MM, Veisi Raygani A, Ghasemi J, et al. Polymorphism in Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPX) gene in Iranian infertile men. J Reprod Infertil. 2006;7(3):198-208.
Azizi F, Ghafouri-Fard S. Outer Dense Fiber Proteins: Bridging between Male Infertility and Cancer. Arch Iran Med. 2017 May;20(5):320-325.
Bansal SK, Gupta N, Sankhwar SN, Rajender S. Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.PLoS One. 2015 May 14;10(5):e0127007.
Aarabi M, Soltanghoraee H, Amirjannati N, Ghaffari M, Sadeghi MR, Akhondi MM, et al. Testis Specific Gene 10 expression in the testes of patients with non-obstructive azoospermia. J Reprod Infertil. 2006;7(3):179-186.
Mardi Mamaghani A., Hosseini SJ., Moslemi E., Hormonal profiling and clusterin gene expression in non-obstructive azoospermic patients, Tehran Univ Med J (TUMJ) 2018 February;75(11):819-27.
Faghihi Zohani, F.; Shahhoseini, M.; Favaedi, R.; Sadighi Gilani, M. A.; Shahzadeh Fazeli, A., Gene expression analysis of H2B histone variant hTSH2B in testis tissues of non-obstructive azoospermic patients referred to Royan Institute, Iranian Journal of Reproductive Medicine. 2013AprSupp, p44-45. 2p.
Aarabi M, Ousati-Ashtiani Z, Nazarian A, Modarressi MH, Heidari M. Association of TGIFLX/Y mRNA expression with azoospermia in infertile men. Mol Reprod Dev. 2008 Dec;75(12):1761-6.
Faghihi Zohani F, Shahhoseini M, Favaedi R, Sadighi Gilani MA, Farhangniya M, Shahzadeh Fazeli SA., Gene Expression Analysis of the Histon Variant H2BFWT in Testis Tissues of Non-Obstructive Azoospermic Patients Referred to Royan Institute, Volume 8, Supplement 1, Summer 2014 (Presented at 15th Congress on Reproductive Biomedicine and 9th Royan Nursing and Midwifery Seminar) Pages: 242-242.
Poongothai J, Gopenath TS, Manonayaki S. Genetics of human male infertility.Singapore Med J. 2009 Apr;50(4):336-47.
Moghbelinejad S, Mozdarania H, Ghoraeian P, Asadi R. Basic and clinical genetic studies on male infertility in Iran during 2000-2016: A review. Int J Reprod Biomed (Yazd). 2018.
Barratt CLR, Björndahl L, De Jonge CJ, Lamb DJ, Osorio Martini F, McLachlan R,Oates RD, van der Poel S, St John B, Sigman M, Sokol R, Tournaye H. The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities. Hum Reprod Update. 2017 Nov 1;23(6):660-680.
Saliminejad K, Khorshid HR. Methodological errors in screening of Yq microdeletion in Iranian azoospermic men. Indian J Med Res. 2012;135: 137–8.
Saliminejad K, Khorshid HR. Discrepancy in the results of Y chromosome microdeletions in an Iranian population. J Hum Reprod Sci. 2011;4(3):157.
Mozdarani H, Ghoraeian P, Mozdarani S, Fallahi P, Mohseni-Meybodi A. High frequency of de novo DAZ microdeletion in sperm nuclei of subfertile men:possible involvement of genome instability in idiopathic male infertility. Hum Fertil (Camb). 2018 Jun;21(2):137-145.
Mozdarani H, Ghoraeian P. Efficient combined FISH and PRINS technique for detection of DAZ microdeletion in human sperm. J Assist Reprod Genet. 2012 Sep;29(9):979-84.
Tüttelmann F. and Simoni M., Current Recommendations for Genetic Testing in Male Infertility, European Urological Review • January 2008.
- Abstract Viewed: 477 times
- PDF Downloaded: 236 times