The effect of low-grade intraventricular hemorrhage on neurodevelopment of very low birth weight infants
Iranian Journal of Child Neurology,
Vol. 16 No. 3 (2022),
16 July 2022
,
Page 57-65
https://doi.org/10.22037/ijcn.v16i3.32958
Abstract
Objective
Intraventricular hemorrhage (IVH) is a significant concern for premature very low birth weight (VLBW) neonates worldwide. Recently, the popular theory of the benign nature of low-grade IVH has been argued with uncertain outcomes. This study has aimed to assess the effect of low-grade IVH on neurodevelopment of VLBW neonates.
Materials & methods
This was a six-month follow-up cohort study conducted on VLBW neonates with and without grade I-II IVH diagnosed through brain ultrasonography. The participants were neurologically examined at birth and within six months. Their neurodevelopment was assessed using Bayley-III questionnaire evaluating cognition, receptive language, expressive language, fine motor and gross motor performance.
Results
100 VLBW neonates including 40 cases with grade I-II IVH diagnosed through brain ultrasonography and 60 controls were recruited. The cases and controls were similar considering gestational age, body birth weight, hospitalization duration, gender distribution and age at Bayley-III evaluation (P>0.05). The neurological assessments at birth showed no significant difference between the two groups (P=0.20), while controls were significantly showed better results in the sixth month of age (P =0.004). Assessing different neurodevelopmental indices, after controlling for demographic characteristics and respiratory-related variables at the time of Bayley-III evaluation, There was a higher performance in cognition and gross motor aspects in controls compared with cases (P= 0.04 and 0.03, respectively).
Conclusions
The low-grade IVH affected the sixth-month neurological examination and gross motor performance of the VLBW newborns. Notably, cognition and gross motor were the two affected subscales in the presence of low-grade IVH, independent of demographic factors.
- Very low birth weight neonate
- Intraventricular hemorrhage
- Bayley-III
- Premature
- neurodevelopment
How to Cite
References
2. Calisici E, Eras Z, Oncel MY, Oguz SS, Gokce İK, Dilmen U. Neurodevelopmental outcomes of premature infants with severe intraventricular hemorrhage. The Journal of Maternal-Fetal & Neonatal Medicine. 2015;28(17):2115-20.
3. Ballabh P. Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatric research. 2010;67(1):1.
4. Miller SP, Ferriero DM, Leonard C, Piecuch R, Glidden DV, Partridge JC, et al. Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome. The Journal of pediatrics. 2005;147(5):609-16.
5. Leviton A, Kuban K, Paneth N. Intraventricular haemorrhage grading scheme: time to abandon? Acta Pædiatrica. 2007;96(9):1254-6.
6. Papile L-A, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. The Journal of pediatrics. 1978;92(4):529-34.
7. Deng W, Pleasure J, Pleasure D. Progress in periventricular leukomalacia. Archives of neurology. 2008;65(10):1291-5.
8. Inder TE. Neurodevelopmental impact of low-grade intraventricular hemorrhage in very preterm infants. The Journal of pediatrics. 2006;149(2):152-4.
9. Bolisetty S, Dhawan A, Abdel-Latif M, Bajuk B, Stack J, Lui K. Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Pediatrics. 2014;133(1):55-62.
10. Radic JA, Vincer M, McNeely PD. Outcomes of intraventricular hemorrhage and posthemorrhagic hydrocephalus in a population-based cohort of very preterm infants born to residents of Nova Scotia from 1993 to 2010. Journal of Neurosurgery: Pediatrics. 2015;15(6):580-8.
11. Payne AH, Hintz SR, Hibbs AM, Walsh MC, Vohr BR, Bann CM, et al. Neurodevelopmental outcomes of extremely low-gestational-age neonates with low-grade periventricular-intraventricular hemorrhage. JAMA pediatrics. 2013;167(5):451-9.
12. Soleimani F, Azari N, Kraskian Mojembari A, Vameghi R, Sajedi F. Developing of the Persian version of Bayley scales of infant and toddlers development screening test and determine its validity and reliability. Journal of Rehabilitation. 2014;14(6):18-29.
13. Azari N, Soleimani F, Vameghi R, SAJEDI F, Shahshahani S, Karimi H, et al. A psychometric study of the Bayley scales of infant and toddler development in Persian language children. Iranian journal of child neurology. 2017;11(1):50.
14. Stewart A, Thorburn R, Hope P, Goldsmith M, Lipscomb A, Reynolds E. Ultrasound appearance of the brain in very preterm infants and neurodevelopmental outcome at 18 months of age. Archives of Disease in Childhood. 1983;58(8):598-604.
15. Jakobi P, Weissman A, Zimmer EZ, Blazer S. Survival and long-term morbidity in preterm infants with and without a clinical diagnosis of periventricular, intraventricular hemorrhage. European Journal of Obstetrics & Gynecology and Reproductive Biology. 1992;46(2-3):73-7.
16. Vavasseur C, Slevin M, Donoghue V, Murphy J. Effect of low grade intraventricular hemorrhage on developmental outcome of preterm infants. The Journal of pediatrics. 2007;151(2):e6.
17. Klebermass-Schrehof K, Czaba C, Olischar M, Fuiko R, Waldhoer T, Rona Z, et al. Impact of low-grade intraventricular hemorrhage on long-term neurodevelopmental outcome in preterm infants. Child's nervous system. 2012;28(12):2085-92.
18. Patra K, Wilson-Costello D, Taylor HG, Mercuri-Minich N, Hack M. Grades I-II intraventricular hemorrhage in extremely low birth weight infants: effects on neurodevelopment. The Journal of pediatrics. 2006;149(2):169-73.
19. Sherlock RL, Anderson PJ, Doyle LW, Group VICS. Neurodevelopmental sequelae of intraventricular haemorrhage at 8 years of age in a regional cohort of ELBW/very preterm infants. Early human development. 2005;81(11):909-16.
20. Reubsaet P, Brouwer AJ, van Haastert IC, Brouwer MJ, Koopman C, Groenendaal F, et al. The impact of low-grade germinal matrix-intraventricular hemorrhage on neurodevelopmental outcome of very preterm infants. Neonatology. 2017;112(3):203-10.
21. Woodward LJ, Anderson PJ, Austin NC, Howard K, Inder TE. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants. New England Journal of Medicine. 2006;355(7):685-94.
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