How Antiepileptics May Change the Serum Level of Vitamin D, Calcium, and Phosphorus in Children with Epilepsy
Iranian Journal of Child Neurology,
Vol. 15 No. 1 (2021),
1 January 2021
,
Page 19-27
https://doi.org/10.22037/ijcn.v15i1.25952
Abstract
Abstract
Objective
Studies have shown vitamin (Vit) D deficiency and bone disease in long-term use of antiepileptics, especially in young individuals. This study aimed to determine the relationship between antiepileptic drugs
and the level of Vit D, calcium (Ca), and phosphorus (P) in children with epilepsy at the Shohada Hospital from 2016 to 2017.
Methods & Materials
In this case-control study, 60 consecutive children with epilepsy at the Shohada Hospital from 2016 to 2017 under treatment with anticonvulsions for more than six months were enrolled as the case group.
The level of Vit D, Ca, and P was determined in the case group and compared with 60 children without seizure as the control group.
Results
The mean Ca and P were alike across the groups (P > 0.05). The mean Vit D3 level was 31.3 and 40 in the case and control groups, respectively, with significant difference (P=0.0001). The mean Ca and P were alike across the types of drug in the case group (P > 0.05); however, the mean Vit D3 level was lower in the case versus control
group with significant difference (P=0.040).
Conclusion
Totally, according to the obtained results, it may be concluded that treatment with antiepileptic drugs, especially stimulant type, is related to the lower Vit D3 level, but not to the Ca and P levels.
- Epilepsy, Antiepileptic, Vitamin Ddeficiency, Long-term, Children
How to Cite
References
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