Comparison of Resistance, Aerobic and Combined Trainings Effects on the FGF21 Serum Levels in Active Elderly Men
Advances in Nursing & Midwifery,
Vol. 29 No. 4 (2020),
15 October 2020
Introduction: The FGF-21 biomarker is an essential factor in reducing the incidence of various cancers and improving the metabolic status of individuals, and improving the metabolic of heart cells. This study aimed to assess the difference between the effect of resistance, aerobic, and combined training on the salivary levels of FGF-21 in active older men.
Methods: The present study method was semi-experimental and performed with a pre-post-test design and three experimental groups. The subjects were randomly assigned to study 36 divided into three groups 1. Resistance training, 2. Aerobic training, and 3. Combined training (n = 12). The serum FGF-21 salivary value in subjects was evaluated and recorded using special sandwich analysis methods by special kits according to the kit brochure's method. The subjects then performed relevant training protocols for eight weeks, after which the post-test data training was evaluated and recorded similar to the pretest conditions. Statistical analysis was performed using descriptive statistical tests, dependent t-test, one-way ANOVA, and Scheffe post hoc in SPSS version 24. The significant level was 0.05.
Results: The results showed that the number of salivary FGF-21 increased significantly after applying aerobic, resistance, and combined training, and this increase was 38.9%, 23.8%, and 14.7% for combined, resistance, and aerobic activity, respectively.
Conclusions: According to the findings of this study, combined exercises should be used to improve metabolic risk factors and reduce the risk of cancer due to increased FGF-21 levels in the elderly community.
- Resistance Exercise,
- Aerobic Exercise
- Combined Exercise
- FGF-21 and Aging
How to Cite
2. Eskandarpor. Fateme, Tofighi. Asghar, toloeeazar. Javad, (2018). The effect of 8 weeks of circular resistance training with thyme supplementation on serume FGF-21 in overweight postmenopausal women. Applied health studies in exercise physiology. Pp 20-27.
3. Fábio S, Lira G, Pimentel D, Ronaldo VT. (2011). Exercise training improves sleep pattern and metabolic profile in elderly people in a time-dependent manner. Lipids Health Dis.10: 113-124.
4. Ghafari. Ghafor, Bolboli. Lotfali, Rajabi. Ali, Saeedmocheshki saber. (2015). The effect of 8 weeks of aerobic training on inflammatory markers predicting atherosclerosis and lipid profile in obese elderly women. Journal of Ilam University of Medical Sciences. Period 23. N 7.
5. Jerome L. FlegAerobic Exercise in the Elderly: A Key to Successful Aging. Specialty: Aging, Cardiology. Institution: Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health. Address: 6701 Rockledge. Bethesda, Maryland, 20892, United States.
6. Karami. Marzie, Banitalebi. Ebrahim, (2017). The effect of 8 weeks of intense interval training and strength- endurance combination on serume FGF-21 levels in type 2 diabetic women. Journal of Nursing Education. Period 6. N 3.
7. Martthian. W, Thays. Angel. M, Flavia. G, Franciel. J, Elizabeth. T. Physical exercise and vascular endothelial growth factor (VEGF) in elderly: A systematic review. Archives of Gerontology and Geriatrics. 2016; 59(2): 234–39.
8. Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP. Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. The American journal of clinical nutrition. 2015;101(5):991-9.
9. Ramezani. Alireza, gaeeni. Abbasali, Hoseini. Morad, Mohammadi. Jamshid. (2017). Evaluation of changes in cardiovascular metabolic risk factors after 8 weeks of endurance and combination training in inactive obese children up to 12 years. Journal sport physiology. N 36. Pp 89-108.
10. ShanhuiXie, Liping Lu, Liwei Liu, Growth differentiation factor-15 and the risk of cardiovascular diseases and all-cause mortality: A meta-analysis of prospective studies, Clinical Cardiology Wiley, 2019, 10.1002/clc.23159.
11. Sori. Rahman, HssanyRanjbar. Shirin, Vahabi. Kobra, Shabkhiz. Fateme, (2011), the effect of aerobic interval training on serum RBP and insulin resistance index in type 2 diabetic patients. journalDiabete and metabolic iran. 10. (4): 388-397.
12. Thomas Morville, Ronni E. Sahl, Samuel A.J. Trammell, Jens S. Svenningsen, Matthew P. Gillum, JOrn W. Helge, and ChristofferClemmensen, Divergent effects of resistance andendurance exercise on plasma bile acids, FGF19, and FGF21 in humans, Clinical Medicine, 2018, 3(15).
13. T. Inagaki, P. Dutchak G. Zhao, X. Ding. L Gautron, V. Parameswara, Y. Li, R. Goetz, ML Mohammadi. V. Esser, J.K. Elmquist, R.D. Gerard. S.C. Burgess, R.E Hammer, D.J. Mangelsdorf, SA. Kliewer, Endocrine regulation of the fasting response by IPARalpha-mediated induction of fibroblast growth factor 21, Cell Metab. 5 (2007) 415-425.
14. Vissers. D, Hens. W, Taeymans. J, Baeyens. JP. (2013). The effect of exercise on visceral adipose tissue in overweight adults: a systematic review and meta-analysis. PLoS One. 8(2):56415-255.
15. W.W. Chen, L. Li, G.Y. Yang, K. Li, X.Y. Qi, W. Zhu, Y. Tang, H. Liu, G. Bonden, Circulating FGF-21 levels in normal subjects and in newly diagnose patients with type 2 diabetes mellitus, Exp. Clin. Endocrinol. Diabetes 116 (2008) 65-68.
16. W. wente, A.M. efanov, M. Brenner, A. Kharitonenkov, A. Koster, G.E. Sandusky. S. Sewing, I. Treinies, H. Zitzer, J. Gromada, Fibroblast growth factor – 21 improves pancreatic beta- cell function and survival by activation of extracellular signal-regulated kinase 1/2 and AKt signaling pathways, Diabetes 55 (2006) 2470-2478.
17. X. Wu, B. Lemon, X. Li, J. Gupre, J. Weiszmann, j. Stevens, N. Hawkins, W. Shen, R. Lindberg, j.L. Chen, H. Tian, Y. Li, derminal tail of FGF 19 determines its specificity toward Klotho co-reseptors, j. Bial chem. 283 (2008) 33304-33309.
18. Y. Izumiya, H.A. Bina, N. Ouchi, Y. Akasaki, A. Kharitonenkov, K. walsh, FGF21 is an AKt-regulated myokine, FEBS Lett. 582 (2008) 3805-3810.
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