Visual and Refractive Outcomes after Topographic-Guided Customized Ablation Photorefractive Keratectomy in Keratoconic Eyes
Journal of Ophthalmic and Optometric Sciences,
Vol. 7 No. 4 (2023),
23 September 2023
,
Page 7-11
https://doi.org/10.22037/joos.v7i4.47444
Abstract
Purpose: To investigate the visual and refractive outcomes of topographic-guided customized ablation treatment (T-CAT) photorefractive keratectomy (PRK) combined with iris registration and the use of mitomycin C among patients who have undergone corneal transplantation.
Patients and Methods: This cross-sectional study was conducted on 18 eyes of 14 patients with keratoconus over a 2-year period at Torfeh Eye Hospital, Tehran, Iran. Of these patients, 11 patients were male and 3 patients were female. All participants had previously undergone penetrating keratoplasty (PKP) or deep anterior lamellar keratoplasty (DALK) and subsequently underwent T- CAT PRK surgery with 0.02 % mitomycin C to correct residual refractive errors due to intolerance or reluctance to wear glasses or contact lenses. Pre- and post- T-CAT PRK surgery assessments included uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), cylindrical and spherical lens measurements, spherical equivalent, and corneal opacity in the transplanted cornea.
Results: The mean postoperative spherical equivalent decreased from 4.27 ± 2.28 D to 1.48 ± 1.39 D, a statistically significant reduction (P = 0.001). The improvements in UCVA, BCVA, and spherocylinder levels were also statistically significant during the follow-up periods after PRK.
Conclusion: The present study suggest that T-CAT PRK combined with iris registration and the use of mitomycin C intraoperatively in keratoconus patients who have undergone corneal transplantation can effectively treat spherical astigmatism. This approach significantly reduced refractive errors and improved visual and refractive parameters.
- Keratoconus
- Keratoplasty
- Refractive Error
- Topography
- Photorefractive Keratectomy
How to Cite
References
Espandar L, Meyer J. Keratoconus: overview and update on treatment. Middle East Afr J Ophthalmol. 2010;17(1):15-20.
Gordon-Shaag A, Millodot M, Shneor E, Liu Y. The genetic and environmental factors for keratoconus. Biomed Res Int. 2015;2015:795738.
Unni P, Lee HJ. Systemic Associations with Keratoconus. Life (Basel). 2023;13(6):1363.
Naderan M, Jahanrad A, Balali S. Histopathologic findings of keratoconus corneas underwent penetrating keratoplasty according to topographic measurements and keratoconus severity. Int J Ophthalmol. 2017;10(11):1640-6.
Kanclerz P, Przewłócka K, Toprak I, Alio J. The prevalence of keratoconus in northern Poland: A cross-sectional study of patients from a primary healthcare practice. Cont Lens Anterior Eye. 2023;46(4):101846.
Jonas JB, Nangia V, Matin A, Kulkarni M, Bhojwani K. Prevalence and associations of keratoconus in rural maharashtra in central India: the central India eye and medical study. Am J Ophthalmol. 2009;148(5):760-5.
Ziaei H, Jafarinasab MR, Javadi MA, Katibeh M, Poorsalman H, Karimian F, et al. Epidemiology of Keratoconus in Yazd Province. Bina J Ophthalmol. 2010;16(1):9-18.
4. Bui AD, Truong A, Pasricha ND, Indaram M. Keratoconus Diagnosis and Treatment: Recent Advances and Future Directions. Clin Ophthalmol. 2023;17:2705-18.
Leccisotti A. Photorefractive keratectomy with mitomycin C after deep anterior lamellar keratoplasty for keratoconus. Cornea. 2008;27(4):417-20.
Nowrouzi A, D'Oria F, Alió Del Barrio JL, Alió JL. Phakic intraocular Lens implantation in keratoconus patients. Eur J Ophthalmol. 2023:11206721231199780.
Keane M, Coster D, Ziaei M, Williams K. Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus. Cochrane Database Syst Rev. 2014;2014(7):CD009700.
Bineshfar N, Tahvildari A, Feizi S. Management of post-keratoplasty ametropia. Ther Adv Ophthalmol. 2023;15:25158414231204717.
Shetty R, D'Souza S, Srivastava S, Ashwini R. Topography-guided custom ablation treatment for treatment of keratoconus. Indian J Ophthalmol. 2013;61(8):445-50.
Ramamurthy S, Soundarya B, Sachdev GS. Topography-guided treatment in regular and irregular corneas. Indian J Ophthalmol. 2020;68(12):2699-704.
Chang DH, Hardten DR. Refractive surgery after corneal transplantation. Curr Opin Ophthalmol. 2005;16(4):251-5.
Forseto Ados S, Marques JC, Nosé W. Photorefractive keratectomy with mitomycin C after penetrating and lamellar keratoplasty. Cornea. 2010;29(10):1103-8.
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