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  3. Vol. 7 No. 2 (2023): Spring
  4. Original Articles

Vol. 7 No. 2 (2023)

Farvardin 2023

Ocular Manifestations of COVID-19 among Patients Admitted to the Intensive Care Unit of Khatam-Al-Anbia Tertiary Center, Tehran, Iran

  • Nafeeseh Montazerin
  • Zhale Rajavi
  • Hossein Ziaei Ardakani
  • Azadeh Haseli-Mofrad

Journal of Ophthalmic and Optometric Sciences, Vol. 7 No. 2 (2023), 2 Farvardin 2023 , Page 14-24
https://doi.org/10.22037/joos.v7i2.45976 Published: 2023-04-02

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Abstract

Purpose: This study reports ocular findings in patients with COVID-19 diagnosis admitted to the intensive care unit of Khatam-Al-Anbia Tertiary Center, Tehran, Iran, from October 2020 to October 2021.
Patients and Methods: In this case series study, comprehensive ophthalmic examinations of patients admitted with COVID-19 diagnosis to the intensive care unit of Khatam-Al-Anbia Tertiary Center, Tehran, Iran, was performed and data were collected during one year (October 2020 - October 2021). This included assessments of the eyelids, conjunctiva, extraocular muscle motility, anterior and posterior segments, orbit, and paraclinical imaging.
Results: The most prevalent ophthalmic findings were conjunctival problems (62.5 %), multiple manifestations (45.8 %), eyelid issues (41.6 %), and proptosis (37.5 %). Other manifestations were less common. Notably, mucormycosis involvement and its impact on the disease course were significant, regardless of its low frequency. It was observed that the female gender showed greater resistance to the infection and its complications.
Conclusion: Ophthalmic manifestations of Covid-19 are common and should be considered in patients’ care. Serious ophthalmic manifestations although rare might lead to severe visual impairments. Central nervous system involvement severely decreases the chance of survival and gender plays a role, in patients’ reaction to the infection.

Keywords:
  • Ophthalmic
  • Manifestation
  • Mucormycosis
  • Covid-19; Neurologic
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How to Cite

Montazerin, N., Rajavi, Z., Ziaei Ardakani, H., & Haseli-Mofrad , A. (2023). Ocular Manifestations of COVID-19 among Patients Admitted to the Intensive Care Unit of Khatam-Al-Anbia Tertiary Center, Tehran, Iran. Journal of Ophthalmic and Optometric Sciences, 7(2), 14–24. https://doi.org/10.22037/joos.v7i2.45976
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References

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33.

Wu P, Duan F, Luo C, Liu Q, Qu X, Liang L, et al. Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020;138(5):575-8.

Sen M, Honavar SG, Sharma N, Sachdev MS. COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19. Indian J Ophthalmol. 2021;69(3):488-509.

Yan Y, Diao B, Liu Y, Zhang W, Wang G, Chen X. Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein in the Ocular Tissues of a Patient Previously Infected With Coronavirus Disease 2019. JAMA Ophthalmol. 2020;138(11):1201-4.

Willcox MD, Walsh K, Nichols JJ, Morgan PB, Jones LW. The ocular surface, coronaviruses and COVID-19. Clin Exp Optom. 2020;103(4):418-24.

Fernández Alcalde C, Granados Fernández M, Nieves Moreno M, Calvo Rey C, Falces Romero I, Noval Martín S. COVID-19 ocular findings in children: a case series. World J Pediatr. 2021;17(3):329-34.

Mehta S, Pandey A. Rhino-Orbital Mucormycosis Associated With COVID-19. Cureus. 2020;12(9):e10726.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13.

Rawson TM, Moore LSP, Zhu N, Ranganathan N, Skolimowska K, Gilchrist M, et al. Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing. Clin Infect Dis. 2020;71(9):2459-68.

Zhang H, Zhang Y, Wu J, Li Y, Zhou X, Li X, et al. Risks and features of secondary infections in severe and critical ill COVID-19 patients. Emerg Microbes Infect. 2020;9(1):1958-64.

Sen M, Lahane S, Lahane TP, Parekh R, Honavar SG. Mucor in a Viral Land: A Tale of Two Pathogens. Indian J Ophthalmol. 2021;69(2):244-52.

Song G, Liang G, Liu W. Fungal Co-infections Associated with Global COVID-19 Pandemic: A Clinical and Diagnostic Perspective from China. Mycopathologia. 2020;185(4):599-606.

Guo D, Xia J, Wang Y, Zhang X, Shen Y, Tong JP. Relapsing viral keratoconjunctivitis in COVID-19: a case report. Virol J. 2020;17(1):97.

Douglas KAA, Douglas VP, Moschos MM. Ocular Manifestations of COVID-19 (SARS-CoV-2): A Critical Review of Current Literature. In Vivo. 2020;34(3 Suppl):1619-28.

Dinkin M, Gao V, Kahan J, Bobker S, Simonetto M, Wechsler P, et al. COVID-19 presenting with ophthalmoparesis from cranial nerve palsy. Neurology. 2020;95(5):221-3.

Öncül H, Öncül FY, Alakus MF, Çağlayan M, Dag U. Ocular findings in patients with coronavirus disease 2019 (COVID-19) in an outbreak hospital. J Med Virol. 2021;93(2):1126-32.

Chen L, Liu M, Zhang Z, Qiao K, Huang T, Chen M, et al. Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020;104(6):748-51.

Sindhuja K, Lomi N, Asif MI, Tandon R. Clinical profile and prevalence of conjunctivitis in mild COVID-19 patients in a tertiary care COVID-19 hospital: A retrospective cross-sectional study. Indian J Ophthalmol. 2020;68(8):1546-50.

Aggarwal K, Agarwal A, Jaiswal N, Dahiya N, Ahuja A, Mahajan S, et al. Ocular surface manifestations of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. PLoS One. 2020;15(11):e0241661.

Meduri A, Oliverio GW, Mancuso G, Giuffrida A, Guarneri C, Venanzi Rullo E, et al. Ocular surface manifestation of COVID-19 and tear film analysis. Sci Rep. 2020;10(1):20178.

Gascon P, Briantais A, Bertrand E, Ramtohul P, Comet A, Beylerian M, et al. Covid-19-Associated Retinopathy: A Case Report. Ocul Immunol Inflamm. 2020;28(8):1293-7.

Virgo J, Mohamed M. Paracentral acute middle maculopathy and acute macular neuroretinopathy following SARS-CoV-2 infection. Eye (Lond). 2020;34(12):2352-3.

Dumitrascu OM, Volod O, Bose S, Wang Y, Biousse V, Lyden PD. Acute ophthalmic artery occlusion in a COVID-19 patient on apixaban. J Stroke Cerebrovasc Dis. 2020;29(8):104982.

Invernizzi A, Pellegrini M, Messenio D, Cereda M, Olivieri P, Brambilla AM, et al. Impending Central Retinal Vein Occlusion in a Patient with Coronavirus Disease 2019 (COVID-19). Ocul Immunol Inflamm. 2020;28(8):1290-2.

Walinjkar JA, Makhija SC, Sharma HR, Morekar SR, Natarajan S. Central retinal vein occlusion with COVID-19 infection as the presumptive etiology. Indian J Ophthalmol. 2020;68(11):2572-4.

Chen L, Deng C, Chen X, Zhang X, Chen B, Yu H, et al. Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study. Acta Ophthalmol. 2020;98(8):e951-9.

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020 1;77(6):683-90.

Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol. 2020;19(5):383-4.

Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020;92(6):552-5.

Hargrove RN, Wesley RE, Klippenstein KA, Fleming JC, Haik BG. Indications for orbital exenteration in mucormycosis. Ophthalmic Plast Reconstr Surg. 2006;22(4):286-91.

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