Journal of Ophthalmic and Optometric Sciences

Vol. 7 No. 2 (2023)

The Relationship between Keratoconus and Joint Hypermobility

Journal of Ophthalmic and Optometric Sciences, Vol. 7 No. 2 (2023), 2 April 2023 , Page 9-13
https://doi.org/10.22037/joos.v7i2.45975

Abstract

Purpose: To evaluate the relation between joint hypermobility and keratoconus.
Patients and Methods: This case-control study was conducted at the Ophthalmology Department of Baqiyatallah Hospital, Tehran, Iran, from September 2020 to April 2021. The case group consisted of patients with keratoconus, while the control group included healthy individuals. The hypermobility score (Beighton test) was calculated for patients in both groups.
Results: A total of 127 keratoconus patients were enrolled as the case group. Additionally, 34 healthy individuals were evaluated as the control group. When comparing joint hypermobility individually, the case group showed significantly higher spinal column forward flexion hypermobility (P < 0.01) and elbow joint hypermobility (P = 0.03). In the case group, 43 patients (33 %) had a Beighton mobility score of more than 4, implying general joint hypermobility, compared to 8 patients (23.5 %) in the control group, indicating no statistically significant difference between the two groups (P = 0.22). Despite the lack of correlation between general joint hypermobility and the presence or absence of keratoconus, a significant correlation was observed between the severity of keratoconus and joint hypermobility in patients with keratoconus, such that higher stages of keratoconus were associated with greater joint hypermobility (P < 0.001).
Conclusion: Based on our findings, it can be concluded that although joint hypermobility and keratoconus may not necessarily be related diseases, there might be a correlation between the severities of these two conditions.

Keywords:
  • Keratoconus
  • Joint Hypermobility Syndrome
  • Correlation

How to Cite

Daryabari, S. H., Mansourian , S., & Shiravandi, A. (2023). The Relationship between Keratoconus and Joint Hypermobility . Journal of Ophthalmic and Optometric Sciences, 7(2), 9–13. https://doi.org/10.22037/joos.v7i2.45975

References

- Castori M. Joint hypermobility in children: a neglected sign needing more attention. Minerva Pediatr. 2020;72(2):123-33.

- Ituen OA, Anieto EM, Ferguson G, Duysens J, Smits-Engelsman B. Prevalence and Demographic Distribution of Hypermobility in a Random Group of School-Aged Children in Nigeria. Healthcare (Basel). 2023;11(8):1092.

- Blajwajs L, Williams J, Timmons W, Sproule J. Hypermobility prevalence, measurements, and outcomes in childhood, adolescence, and emerging adulthood: a systematic review. Rheumatol Int. 2023;43(8):1423-44.

- Simmonds JV, Keer RJ. Hypermobility and the hypermobility syndrome. Man Ther. 2007;12(4):298-309.

- Buckley MR, Evans EB, Matuszewski PE, Chen YL, Satchel LN, Elliott DM, et al. Distributions of types I, II and III collagen by region in the human supraspinatus tendon. Connect Tissue Res. 2013;54(6):374-9.

- Kuivaniemi H, Tromp G. Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases. Gene. 2019;707:151-71.

- Malfait F, Hakim AJ, De Paepe A, Grahame R. The genetic basis of the joint hypermobility syndromes. Rheumatology (Oxford). 2006;45(5):502-7.

- Vazirani J, Basu S. Keratoconus: current perspectives. Clin Ophthalmol. 2013;7:2019-30.

- Romero-Jiménez M, Santodomingo-Rubido J, Wolffsohn JS. Keratoconus: a review. Cont Lens Anterior Eye. 2010;33(4):157-66.

- Marx-Gross S, Fieß A, Münzel T, Wild PS, Beutel ME, Schmidtmann I, et al. Much higher prevalence of keratoconus than announced results of the Gutenberg Health Study (GHS). Graefes Arch Clin Exp Ophthalmol. 2023;261(11):3241-7.

- Gomes JAP, Rodrigues PF, Lamazales LL. Keratoconus epidemiology: A review. Saudi J Ophthalmol. 2022;36(1):3-6.

- Duncan JK, Belin MW, Borgstrom M. Assessing progression of keratoconus: novel tomographic determinants. Eye Vis (Lond). 2016;3:6.

- Sinha Roy A, Shetty R, Kummelil MK. Keratoconus: a biomechanical perspective on loss of corneal stiffness. Indian J Ophthalmol. 2013;61(8):392-3.

- Woodward EG, Morris MT. Joint hypermobility in keratoconus. Ophthalmic Physiol Opt. 1990;10(4):360-2.

- Robertson I. Keratoconus and the Ehlers-Danlos syndrome: a new aspect of keratoconus. Med J Aust. 1975;1(18):571-3.

- Street DA, Vinokur ET, Waring GO 3rd, Pollak SJ, Clements SD, Perkins JV. Lack of association between keratoconus, mitral valve prolapse, and joint hypermobility. Ophthalmology. 1991;98(2):170-6.

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