Protein-Protein Interaction Network Study Reveals New Possible Endocrine Disrupting Chemicals (EDC) ‘ Impact on Retinoblastoma
Journal of Ophthalmic and Optometric Sciences,
Vol. 4 No. 1 (2020),
6 January 2020
,
Page 1-12
https://doi.org/10.22037/joos.v4i1.36960
Abstract
Abstract:
Background: Retinoblastoma (RB) is a retinal-derived embryonic tumor. The illness severity at the time of presentation affects survival and preserves eyesight.
Methods: We explored differential gene expression in retinoblastoma and normal samples to better understand retinoblastoma etiology and find potential Endocrine Disrupting Chemicals(EDCs). The protein-protein interaction network was built using STRING database and displayed through Cytoscape and differentially expressed genes (DEGs) with an adj p-value of less than 0.01. Then, the network produced five PPI modules. After that, the genes in the modules were analyzed for GO and pathway enrichment. For each module's genes, EDC-gene interactions were collected and rebuilt as a single EDC-gene network.
Result: In Retinoblastoma, 347 putative EDCs were discovered to influence gene regulation. The EDC that affects five genes is ethanolamine. For the first time, these EDCs have been suggested as new possible compounds for preventing Retinoblastoma and should be investigated further in clinical trials.
Conclusion: Ethanolamine is a high degree EDC in our network. However, the findings should be experimentally validated to produce better prevention.
- PPI
- retinoblastoma
- EDC
- network
How to Cite
References
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