Ocular Brucellosis: A Brief Update
Journal of Ophthalmic and Optometric Sciences,
Vol. 3 No. 1 (2019),
1 January 2019
,
Page 30-35
https://doi.org/10.22037/joos.v3i1.33693
Abstract
Brucellosis is a zoonotic disease of important health significance in endemic areas such as Iran. Brucellosis can affect any organ or system in the human body. Ocular involvement is rare and can lead to poor visual prognosis if not treated early. The most common ocular manifestation of brucellosis is uveitis, although any ocular structure can be involved. The diagnosis of ocular brucellosis is based on clinical examination as well as culture and serological tests. The classical treatment regimen includes doxycycline and rifampin. Early diagnosis and prompt treatment are effective in preventing blindness. Here we breifly review the manifestations, diagnostic tools, and treatment of ocular brucellosis.
Keywords:
- Brucellosis; ocular; therapeutics; diagnosis; Iran.
How to Cite
Abbas Heydar, A. ., Soleimani, M., & Soleimani , Z. (2019). Ocular Brucellosis: A Brief Update. Journal of Ophthalmic and Optometric Sciences, 3(1), 30–35. https://doi.org/10.22037/joos.v3i1.33693
References
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2. Ndazigaruye G, Mushonga B, Kandiwa E, Samkange A, Segwagwe BE. Prevalence and risk factors for brucellosis seropositivity in cattle in Nyagatare District, Eastern Province, Rwanda. J S Afr Vet Assoc. 2018;89(0):e1-e8.
3. Güngür K, Bekir NA, Namiduru M. Ocular complications associated with brucellosis in an endemic area. Eur J Ophthalmol. 2002;12(3):232-7.
4. Rolando I, Olarte L, Vilchez G, Lluncor M, Otero L, Paris M, et al. Ocular manifestations associated with brucellosis: A 26-Year Experience in Peru. Clin Infect Dis 2008; 46(9):1338-45.
5. Sungur GK, Hazirolan D, Gurbuz Y, Unlu N, Duran S, Duman S. Ocular involvement in brucellosis. Can J Ophthalmol. 2009;44(5):598-601.
6. Dadar M, Alamian S, Behrozikhah AM, Yazdani F, Kalantari A, Etemadi A, Whatmore AM.Vet Res Forum. 2019;10(4):315-21.
7. Serra J, Viñas M. Laboratory diagnosis of brucellosis in a rural endemic area in northeastern Spain. Int Microbiol. 2004;7(1):53-8.
8. Qasem JA, AlMomin S, Al-Mouqati SA, Kumar V. Characterization and evaluation of an arbitrary primed Polymerase Chain Reaction (PCR) product for the specific detection of Brucella species. Saudi J Biol Sci. 2015;22(2):220-6.
9. Rolando I, Vilchez G, Olarte L, Lluncor M, Carrillo C, Paris M, et al. Brucellar uveitis: intraocular fluids and biopsy studies. Int J Infect Dis. 2009;13(5):e206-11.
10. Akduman L, Or M, Hasanreisoglu B, Kurtar K. A case of ocular brucellosis: importance of vitreous specimen. Acta Ophthalmol 1993;71(1):130-2.
11. Solanes MP, Heatley J, Arenas F, Ibarra GG. Ocular complications in brucellosis. Am J Ophthalmol. 1953;36(5):675-89.
12. Bazzazi N, Yavarikia A, Keramat F. Ocular involvement of brucellosis. Middle East Afr J Ophthalmol. 2013;20(1):95-7.
13. Green J. Ocular Manifestations in Brucellosis (Malta Fever; Undulant Fever). Trans Am Ophthalmol Soc. 1938;36:104-26.
14. Ghasemi Barghi R, Meraat H, Pahlevan AA. A review on ophthalmic manifestations of brucellosis and reporting a case of ophthalmic brucellosis. Iran Red Crescent Med J. 2011;13(5):352-3.
15. Mesquida M, Llorenç V, Cervera C, Adan A. Ocular brucellosis. Med Clin (Barc). 2013;140(6):284.
16. Walker J, Sharma OP, Rao NA. Brucellosis and uveitis. Am J Ophthalmol. 1992 ;114(3):374-5.
17. Hatipoglu CA, Yetkin A, Ertem GT, Tulek N. Unusual clinical presentations of brucellosis. Scand J Infect Dis. 2004;36(9):694-7.
18. Moutray T, Williams M, Best R, McGinnity G. Brucellosis: a forgotten cause of uveitis. Asian J Ophthalmol. 2007;9:30-1.
19. Bourcier T, Cassoux N, Karmochkine M, Lehoang P. Episcleritis and brucellosis. Apropos of a case. J Fr Ophtalmol. 1998;21(2):126-7. (Article in French)
20. Güngör K, Bekir NA, Namiduru M. Recurrent episcleritis associated with brucellosis. Acta Ophthalmol Scand. 2001;79(1):76-8.
21. Sahin OG, Pelit A, Turunc T, Akova YA. Ophthalmoparesis, papillitis and premacular hemorrhage in a case with endocarditis: a rare presentation of Brucellosis. Indian J Ophthalmol. 2010;58(2):164-6.
22. Mergen B, Sarici AM, Baltu F, Ozaras R, Adaletli I. An unusual presentation of sixth nerve palsy: neurobrucellosis. GMS Ophthalmol Cases. 2019;9:Doc13.
23. Mete A, Mete AÖ, Kimyon S, Yılmaz İE, Bekir NA. Unilateral Brucella Dacryoadenitis. Eur J Ther. 2018;24(1):61-3.
24. Oray M, Cebeci Z, Kir N, Ozturk BT, Oksuz L, Tugal-Tutkun I. Endogenous Brucella endophthalmitis: A case report.Saudi J Ophthalmol. 2017;31(2):106-8 .
25. Corbel MJ. Brucellosis in humans and animals: World Health Organization; 2006.
26. Ariza J, Bosilkovski M, Cascio A, Colmenero JD, Corbel MJ, Falagaset ME, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med. 2007;4(12):e317.
27. Yousefi-Nooraie R, Mortaz-Hejri S, Mehrani M, Sadeghipour P. Antibiotics for treating human brucellosis. Cochrane Database Syst Rev. 2012;10(10):CD007179.
28. Solera J. Update on brucellosis: therapeutic challenges. Int J Antimicrob Agents. 2010;36 Suppl 1:S18-20.
29. Gulsun S, Aslan S, Satici O, Gul T. Brucellosis in pregnancy. Trop Doct. 2011;41(2):82-4.
30. Roushan MR, Mohraz M, Janmohammadi N, Hajiahmadi M. Efficacy of cotrimoxazole and rifampin for 6 or 8 weeks of therapy in childhood brucellosis. Pediatr Infect Dis J. 2006;25(6):544-5.
31. Gulsun S, Aslan S, Satici O, Gul T. Brucellosis in pregnancy. Trop Doct. 2011;41(2):82-4.
32. Cavallaro N, Randone A, La Rosa L, Mughinin L. Bilateral papilledema in a patient with brucellosis. Metab Pediatr Syst Ophthalmol (1985). 1990;13(2-4):115-8. PMID: 2079902.
33. Abd Elrazak M. Brucella optic neuritis. Arch Intern Med. 1991;151(4):776-8. PMID: 2012464.
34. Geng L, Feng Y, Li D, Nan N, Ma K, Tang X, et al. Meningoencephalitis, coronary artery and keratitis as an onset of brucellosis: a case report. BMC Infect Dis. 2020;20(1):654.
35. Adusumilli H, Krupa L, Shetty NS, Rao S. Bilateral serous choroidal detachment in brucellosis and its management and outcome: Literature review and case report. Indian J Ophthalmol. 2020;68(6):1204-6.
2. Ndazigaruye G, Mushonga B, Kandiwa E, Samkange A, Segwagwe BE. Prevalence and risk factors for brucellosis seropositivity in cattle in Nyagatare District, Eastern Province, Rwanda. J S Afr Vet Assoc. 2018;89(0):e1-e8.
3. Güngür K, Bekir NA, Namiduru M. Ocular complications associated with brucellosis in an endemic area. Eur J Ophthalmol. 2002;12(3):232-7.
4. Rolando I, Olarte L, Vilchez G, Lluncor M, Otero L, Paris M, et al. Ocular manifestations associated with brucellosis: A 26-Year Experience in Peru. Clin Infect Dis 2008; 46(9):1338-45.
5. Sungur GK, Hazirolan D, Gurbuz Y, Unlu N, Duran S, Duman S. Ocular involvement in brucellosis. Can J Ophthalmol. 2009;44(5):598-601.
6. Dadar M, Alamian S, Behrozikhah AM, Yazdani F, Kalantari A, Etemadi A, Whatmore AM.Vet Res Forum. 2019;10(4):315-21.
7. Serra J, Viñas M. Laboratory diagnosis of brucellosis in a rural endemic area in northeastern Spain. Int Microbiol. 2004;7(1):53-8.
8. Qasem JA, AlMomin S, Al-Mouqati SA, Kumar V. Characterization and evaluation of an arbitrary primed Polymerase Chain Reaction (PCR) product for the specific detection of Brucella species. Saudi J Biol Sci. 2015;22(2):220-6.
9. Rolando I, Vilchez G, Olarte L, Lluncor M, Carrillo C, Paris M, et al. Brucellar uveitis: intraocular fluids and biopsy studies. Int J Infect Dis. 2009;13(5):e206-11.
10. Akduman L, Or M, Hasanreisoglu B, Kurtar K. A case of ocular brucellosis: importance of vitreous specimen. Acta Ophthalmol 1993;71(1):130-2.
11. Solanes MP, Heatley J, Arenas F, Ibarra GG. Ocular complications in brucellosis. Am J Ophthalmol. 1953;36(5):675-89.
12. Bazzazi N, Yavarikia A, Keramat F. Ocular involvement of brucellosis. Middle East Afr J Ophthalmol. 2013;20(1):95-7.
13. Green J. Ocular Manifestations in Brucellosis (Malta Fever; Undulant Fever). Trans Am Ophthalmol Soc. 1938;36:104-26.
14. Ghasemi Barghi R, Meraat H, Pahlevan AA. A review on ophthalmic manifestations of brucellosis and reporting a case of ophthalmic brucellosis. Iran Red Crescent Med J. 2011;13(5):352-3.
15. Mesquida M, Llorenç V, Cervera C, Adan A. Ocular brucellosis. Med Clin (Barc). 2013;140(6):284.
16. Walker J, Sharma OP, Rao NA. Brucellosis and uveitis. Am J Ophthalmol. 1992 ;114(3):374-5.
17. Hatipoglu CA, Yetkin A, Ertem GT, Tulek N. Unusual clinical presentations of brucellosis. Scand J Infect Dis. 2004;36(9):694-7.
18. Moutray T, Williams M, Best R, McGinnity G. Brucellosis: a forgotten cause of uveitis. Asian J Ophthalmol. 2007;9:30-1.
19. Bourcier T, Cassoux N, Karmochkine M, Lehoang P. Episcleritis and brucellosis. Apropos of a case. J Fr Ophtalmol. 1998;21(2):126-7. (Article in French)
20. Güngör K, Bekir NA, Namiduru M. Recurrent episcleritis associated with brucellosis. Acta Ophthalmol Scand. 2001;79(1):76-8.
21. Sahin OG, Pelit A, Turunc T, Akova YA. Ophthalmoparesis, papillitis and premacular hemorrhage in a case with endocarditis: a rare presentation of Brucellosis. Indian J Ophthalmol. 2010;58(2):164-6.
22. Mergen B, Sarici AM, Baltu F, Ozaras R, Adaletli I. An unusual presentation of sixth nerve palsy: neurobrucellosis. GMS Ophthalmol Cases. 2019;9:Doc13.
23. Mete A, Mete AÖ, Kimyon S, Yılmaz İE, Bekir NA. Unilateral Brucella Dacryoadenitis. Eur J Ther. 2018;24(1):61-3.
24. Oray M, Cebeci Z, Kir N, Ozturk BT, Oksuz L, Tugal-Tutkun I. Endogenous Brucella endophthalmitis: A case report.Saudi J Ophthalmol. 2017;31(2):106-8 .
25. Corbel MJ. Brucellosis in humans and animals: World Health Organization; 2006.
26. Ariza J, Bosilkovski M, Cascio A, Colmenero JD, Corbel MJ, Falagaset ME, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med. 2007;4(12):e317.
27. Yousefi-Nooraie R, Mortaz-Hejri S, Mehrani M, Sadeghipour P. Antibiotics for treating human brucellosis. Cochrane Database Syst Rev. 2012;10(10):CD007179.
28. Solera J. Update on brucellosis: therapeutic challenges. Int J Antimicrob Agents. 2010;36 Suppl 1:S18-20.
29. Gulsun S, Aslan S, Satici O, Gul T. Brucellosis in pregnancy. Trop Doct. 2011;41(2):82-4.
30. Roushan MR, Mohraz M, Janmohammadi N, Hajiahmadi M. Efficacy of cotrimoxazole and rifampin for 6 or 8 weeks of therapy in childhood brucellosis. Pediatr Infect Dis J. 2006;25(6):544-5.
31. Gulsun S, Aslan S, Satici O, Gul T. Brucellosis in pregnancy. Trop Doct. 2011;41(2):82-4.
32. Cavallaro N, Randone A, La Rosa L, Mughinin L. Bilateral papilledema in a patient with brucellosis. Metab Pediatr Syst Ophthalmol (1985). 1990;13(2-4):115-8. PMID: 2079902.
33. Abd Elrazak M. Brucella optic neuritis. Arch Intern Med. 1991;151(4):776-8. PMID: 2012464.
34. Geng L, Feng Y, Li D, Nan N, Ma K, Tang X, et al. Meningoencephalitis, coronary artery and keratitis as an onset of brucellosis: a case report. BMC Infect Dis. 2020;20(1):654.
35. Adusumilli H, Krupa L, Shetty NS, Rao S. Bilateral serous choroidal detachment in brucellosis and its management and outcome: Literature review and case report. Indian J Ophthalmol. 2020;68(6):1204-6.
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