Posttraumatic Endophthalmitis: Responsible Microorganisms and Rate of Resistance
Journal of Ophthalmic and Optometric Sciences,
Vol. 2 No. 4 (2018),
23 September 2018
,
Page 1-6
https://doi.org/10.22037/joos.v2i4.29973
Abstract
Purpose: To identify the microorganisms responsible for the posttraumatic endophthalmitis and evaluate their resistance to seven antibiotics.
Patients and Methods: Aqueous and vitreous samples were obtained from 49 patients who underwent vitrectomy for posttraumatic endophthalmitis and were inoculated into blood agar, chocolate agar, and Sabouraud agar media. Susceptibility testing was performed using the Kirby-Bauer disk diffusion method for seven antibiotics (vancomycin, ceftazidime, ciprofloxacin, oxacillin, azithromycin, imipenem, and rifampin).
Results: Twenty patients (40.8 %) had intraocular foreign bodies. The cultures were positive in 18 patients (36.7 %). In all patients (except for one case), one species was isolated. The most frequent isolated microorganism was staphylococcus epidermidis in 9 patients (47.4 %), followed by staphylococcus aureus, bacillus species, streptococcus viridans, streptococcus pneumonia, enterococcus, diphtheroid species, and pseudomonas aeruginosa. No case with fungal growth was found. Microorganisms showed higher sensitivity to different antibiotics: all gram-positive cocci were sensitive to vancomycin and 71.4 % were sensitive to ceftazidime or rifampin. All gram-positive bacilli were sensitive to vancomycin, ciprofloxacin and azithromycin. The gram-negative bacillus (pseudomonas) was sensitive to ceftazidime, ciprofloxacin, imipenem, and rifampin.
Conclusion: No single antibiotic was effective against all groups of bacteria present in patients undergoing vitrectomy for posttraumatic endophthalmitis. The conventional intravitreal regimen (vancomycin + ceftazidime) seems to be still valuable in treatment of bacterial endophthalmitis among this group of patients.
Keywords: Endophthalmitis; Microorganisms; Posttraumatic; Drug resistance.
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References
- Chhabra S, Kunimoto DY, Kazi L, Regillo CD, Ho AC, Belmont J, et al. Endophthalmitis after open globe injury: microbiologic spectrum and susceptibilities of isolates. Am J Ophthalmol. 2006;142(5):852-4.
- Kunimoto DY, Das T, Sharma S, Jalali S, Majji AB, Gopinathan, et al. U, Microbiologic spectrum and susceptibility of isolates: part II. Posttraumatic endophthalmitis. Endophthalmitis Research Group. Am J Ophthalmol. 1999;128(2):242-4.
- Rishi E, Rishi P, Koundanya VV, Sahu C, Roy R, Bhende PS. Post-traumatic endophthalmitis in 143 eyes of children and adolescents from India. Eye (Lond). 2016;30(4):615-20.
- Bhattacharjee H, Bhattacharjee K, Gogoi K, Singh M, Singla BG, Yadav A. Microbial profile of the vitreous aspirates in culture proven exogenous endophthalmitis: A 10-year retrospective study. Indian J Med Microbiol. 2016;34(2):153-8.
- El Chehab H, Renard JP, Dot C. Post-traumatic endophthalmitis. J Fr Ophtalmol. 2016;39(1):98-106. (Article in French)
- González-Gross M, Castillo MJ, Moreno L, Nova E, González-Lamuño D, Pérez-Llamas F, et al. Feeding and assessment of nutritional status of spanish adolescents (AVENA study). Evaluation of risks and interventional proposal. I.Methodology. Nutr Hosp. 2003;18(1):15-28. (Article in Spanish)
- Jindal A, Pathengay A, Mithal K, Jalali S, Mathai A, Pappuru RR, Endophthalmitis after open globe injuries: changes in microbiological spectrum and isolate susceptibility patterns over 14 years. J Ophthalmic Inflamm Infect. 2014;4(1):5.
- Nashed A, Saikia P, Herrmann WA, Gabel VP, Helbig H, Hillenkamp J. The outcome of early surgical repair with vitrectomy and silicone oil in open-globe injuries with retinal detachment. Am J Ophthalmol. 2011;151(3):522-8.
- Nicoară SD, Irimescu I, Călinici T, Cristian C. Outcome and Prognostic Factors for Traumatic Endophthalmitis over a 5-Year Period. J Ophthalmol. 2014;2014:747015.
- Banker TP, McClellan AJ, Wilson BD, Juan FM, Kuriyan AE, Relhan N, et al. Culture-Positive Endophthalmitis After Open Globe Injuries With and Without Retained Intraocular Foreign Bodies. Ophthalmic Surg Lasers Imaging Retina. 2017;48(8):632-7.
- Sharma YR, Gaur N, Chandra P, Takkar B. Predictors of Visual Outcomes and Microbial Profile in Endophthalmitis. Ophthalmic Surg Lasers Imaging Retina. 2016;47(11):991-8.
- Long C, Liu B, Xu C, Jing Y, Yuan Z, Lin X. Causative organisms of post-traumatic endophthalmitis: a 20-year retrospective study. BMC Ophthalmol. 2014;14:34.
- Gokce G, Sobaci G, Ozgonul C. Post-Traumatic Endophthalmitis: A Mini-Review. Semin Ophthalmol. 2015;30(5-6):470-4.
- Agrawal R. Post-traumatic endophthalmitis. Eye (Lond). 2012;26(9):1277-8.
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