Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with MS and Normal Population
Journal of Ophthalmic and Optometric Sciences,
Vol. 1 No. 5 (2017),
23 September 2017
,
Page 23-30
https://doi.org/10.22037/joos.v1i5.28011
Abstract
Purpose: To compare peripapillary retinal nerve fiber layer thickness (RNFLT) between patients with multiple sclerosis (MS) and healthy controls using optical coherence tomography (OCT). Patients and Methods: In this prospective case control study, peripapillary RNFLT of 120 eyes from 60 patients with multiple sclerosis (MS) was compared to 120 eyes from 60 age and sex matched healthy controls using OCT. The RNFLT in 4 peripapillary quadrants and the mean RNFLT of all four quadrants were compared between the case and control groups. The relation between MS variables such as age of onset, type and duration of disease, history of optic neuritis (ON) and other non-ocular episodes with RNFLT was evaluated in the case group.
Results: The mean RNFLT of all four quarters was significantly lower in patients with MS compared to the controls (P < 0.001). Also RNFLT was significantly lower in each of 4 quadrants (superior, temporal, inferior; P < 0.001, nasal P = 0.003). There was no significant relation between RNFLT, the age of onset of MS disease, and history of non-ocular episodes. RNFLT had a significant relation with duration of the disease (P < 0.001), the type of MS (P < 0.001), history of ON (P = 0.002), and the number of ON episodes (P = 0.021).
Conclusion: We found that RNFLT decreases in MS patients and its reduction is related to the duration and type of disease as well as history and number of ON episodes. Therefore measuring RNFLT may help in estimating the progress of MS and can potentially be included as a part of patients’ follow up protocol.
Keywords: Multiple sclerosis; Tomography; Optical Coherence;;Optic Neuritis; Retinal; Nerve Fibers
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References
Bitsch A, Schuchardt J, Bunkowski S, Kuhlmann T, Brück W. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain. 2000;123 ( Pt 6):1174-83.
Costello F, Coupland S, Hodge W, Lorello GR, Koroluk J, Pan YI, et al. Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol. 2006;59(6):963-9.
Frohman E, Costello F, Zivadinov R, Stuve O, Conger A, Winslow H, et al. Optical coherence tomography in multiple sclerosis. Lancet Neurol. 2006;5(10):853-63.
Ogden TE. Nerve fiber layer of the primate retina: thickness and glial content. Vision Res. 1983;23(6):581-7.
Frohman EM, Fujimoto JG, Frohman TC, Calabresi PA, Cutter G, Balcer LJ. Optical coherence tomography: a window into the mechanisms of multiple sclerosis. Nat Clin Pract Neurol. 2008;4(12):664-75.
Bock M, Paul F, Dörr J. Diagnosis and monitoring of multiple sclerosis: the value of optical coherence tomography. Nervenarzt. 2013;84(4):483-92. (Article in German)
Hassenstein A, Spital G, Scholz F, Henschel A, Richard G, Pauleikhoff D. [Optical coherence tomography for macula diagnostics. Review of methods and standardized application concentrating on diagnostic and therapy control of age-related macula degeneration]. Ophthalmologe. 2009;106(2):116-26. (Article in German)
Sergott RC, Frohman E, Glanzman R, Al-Sabbagh A; OCT in MS Expert Panel. The role of optical coherence tomography in multiple sclerosis: expert panel consensus. J Neurol Sci. 2007;263(1-2):3-14.
Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, García-Layana A, Bejarano B, Villoslada Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology. 2007;68(18):1488-94.
Henderson AP, Trip SA, Schlottmann PG, Altmann DR, Garway-Heath DF, Plant GT, An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain. 2008;131(Pt 1):277-87.
De Stefano N, Matthews PM, Fu L, Narayanan S, Stanley J, Francis GS, Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain. 1998;121 ( Pt 8):1469-77.
Parisi V, Restuccia R, Fattapposta F, Mina C, Bucci MG, Pierelli F. Morphological and functional retinal impairment in Alzheimer's disease patients. Clin Neurophysiol. 2001;112(10):1860-7.
Inzelberg R, Ramirez JA, Nisipeanu P, Ophir A. Retinal nerve fiber layer thinning in Parkinson disease. Vision Res. 2004;44(24):2793-7.
Ascaso FJ, Rodriguez-Jimenez R, Cabezón L, López-Antón R, Santabárbara J, De la Cámara C, et al. Retinal nerve fiber layer and macular thickness in patients with schizophrenia: Influence of recent illness episodes. Psychiatry Res. 2015;229(1-2):230-6.
Mehraban A, Samimi SM, Entezari M, Seifi MH, Nazari M, Yaseri M. Peripapillary retinal nerve fiber layer thickness in bipolar disorder. Graefes Arch Clin Exp Ophthalmol. 2016;254(2):365-71.
Trip SA, Schlottmann PG, Jones SJ, Altmann DR, Garway-Heath DF, Thompson AJ, Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol. 2005;58(3):383-91.
Huynh SC, Wang XY, Burlutsky G, Rochtchina E, Stapleton F, Mitchell P. Retinal and optic disc findings in adolescence: a population-based OCT study. Invest Ophthalmol Vis Sci. 2008;49(10):4328-35.
Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol. 2005;58(6):840-6.
Henderson AP, Trip SA, Schlottmann PG, Altmann DR, Garway-Heath DF, Plant GT, An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain. 2008;131(Pt 1):277-87.
De Stefano N, Matthews PM, Fu L, Narayanan S, Stanley J, Francis GS, Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain. 1998;121 ( Pt 8):1469-77.
Spain RI, Maltenfort M, Sergott RC, Leist TP. Thickness of retinal nerve fiber layer correlates with disease duration in parallel with corticospinal tract dysfunction in untreated multiple sclerosis. J Rehabil Res Dev. 2009;46(5):633-42.
Singer AJ, Wang Z, McClain SA, Pan Y. Optical coherence tomography: a noninvasive method to assess wound reepithelialization. Acad Emerg Med. 2007;14(5):387-91.
Feng L, Shen J, Jin X, Li J, Li Y. The evaluation of the retinal nerve fiber layer in multiple sclerosis with special-domain optical coherence tomography. Ophthalmologica. 2013;230(3):116-20.
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