A Rare Case of Concurrent Granular Corneal Dystrophy and Keratoconus
Journal of Ophthalmic and Optometric Sciences,
Vol. 1 No. 1 (2016),
A 23-year-old female presented with progressive bilateral visual loss for the past 5 years. The patient had no history of systemic disease, surgery or medications. Complete ophthalmologic examination and topography were performed. On ophthalmic examination, uncorrected visual acuity was 20/30 in the right eye and 20/50 in the left eye. Both corneas appeared hazy on gross examination. On slit-lamp biomicroscopy, few well circumscribed gray white discrete granular deposits in the central corneal stroma of both eyes were observed. Both corneas were thin and bulging. Corneal topography showed a pattern consistent with keratoconus. The patient was clinically diagnosed as a case of concurrent granular dystrophy and keratoconus, which is a very rare presentation.
How to Cite
Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42(4):297-319.
Bawazeer AM, Hodge WG, Lorimer B. Atopy and keratoconus: a multivariate analysis. Br J Ophthalmol. 2000;84(8):834-6.
Cremona FA, Ghosheh FR, Rapuano CJ, Eagle RC Jr, Hammersmith KM, Laibson PR, et al. Keratoconus associated with other corneal dystrophies. Cornea. 2009;28(2):127-35.
Akiya S, Brown SI. Granular dystrophy of the cornea. Characteristic electron microscopic lesion. Arch Ophthalmol. 1970;84(2):179-92.
Dighiero P, Valleix S, D'Hermies F, Drunat S, Ellies P, Savoldelli M, et al. Clinical, histologic, and ultrastructural features of the corneal dystrophy caused by the R124L mutation of the BIGH3 gene. Ophthalmology. 2000;107(7):1353-7.
Mashima Y, Nakamura Y, Noda K, Konishi M, Yamada M, Kudoh J, et al. A novel mutation at codon 124 (R124L) in the BIGH3 gene is associated with a superficial variant of granular corneal dystrophy. Arch Ophthalmol. 1999;117(1):90-3.
Streeten BW, Qi Y, Klintworth GK, Eagle RC Jr, Strauss JA, Bennett K. Immunolocalization of beta ig-h3 protein in 5q31-linked corneal dystrophies and normal corneas. Arch Ophthalmol. 1999;117(1):67-75.
Dinh R, Rapuano CJ, Cohen EJ, Laibson PR. Recurrence of corneal dystrophy after excimer laser phototherapeutic keratectomy. Ophthalmology. 1999;106(8):1490-7.
Lyons CJ, McCartney AC, Kirkness CM, Ficker LA, Steele AD, Rice NS. Granular corneal dystrophy. Visual results and pattern of recurrence after lamellar or penetrating keratoplasty. Ophthalmology. 1994;101(11):1812-7.
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