• Logo
  • SBMUJournals

Expression of let-7 family as a survival biomarker for lung cancer: A meta-analysis

Faezeh Azizi, Fereshteh Aliakbari, Zahra Zolghadr, Reza Hosseini, Reza Hashemi
1

Views

PDF

Abstract

Introduction: Lung cancer is the most common cancer among men around the world. Today, by evaluating the expression of microRNA biomarkers, cancer cells can be detected in specific tissues. However, it's still controversy that the expression of let-7 in the prognosis of patients with lung cancer is informative.

Material and Methods: A meta-analysis was performed by searching Google Scholar, PubMed, Scopus, Web of Science, IranMedex, MEDLIB, IranDoc and Scientific Information Database(SID). All data were extracted from articles comparing prognosis in patients with lung cancer having low expression of let-7 with those having high expression. Pooled hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs) were calculated. Subgroup analyses were conducted for ethnicity.

Results: A total of 1,370 cases of lung cancer were involved for this meta-analysis. The HR of low let-7 expression was 1.32 (95 % CI 0.68–2.58). A subgroup analysis was performed on ethnicity; combined HR was 1.56 (95 % CI 0.52–4.62) for Asians and 1.08 (95%CI 0.42–2.74) for non-Asians.

Conclusion: There was no significant relationship between the expression of let-7 and lung cancer, let-7 might be a biomarker in Asian patients with favourable prognosis. Furthermore, with large-scale investigations, useful prognostic microRNA biomarkers in the diagnosis, treatment and follow-up could be detected.

 


References

Shinagawa N. A review of existing and new methods of bronchoscopic diagnosis of lung cancer. Respiratory investigation. 2018.

Takemura T, Kataoka Y, Okazaki K, Sakurai A, Imakita T, Ikegaki S, et al. Influence of social determinants of health on patients with advanced lung cancer: a prospective cohort study. BMJ open. 2018;8(10):e023152.

Rodriguez-Barranco M, Salamanca-Fernandez E, Fajardo ML, Bayo E, Chang-Chan YL, Exposito J, et al. Patient, tumor, and healthcare factors associated with regional variability in lung cancer survival: a Spanish high-resolution population-based study. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2018.

Tuo L, Chu X, Sha S, Zhang X. [MicroRNA and Lung Cancer: A Mini Review]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. 2018;21(9):727-30.

Yang G, Zhang W, Yu C, Ren J, An Z. MicroRNA let-7: Regulation, single nucleotide polymorphism, and therapy in lung cancer. Journal of cancer research and therapeutics. 2015;11 Suppl 1:C1-6.

Xia Y, Zhu Y, Zhou X, Chen Y. Low expression of let-7 predicts poor prognosis in patients with multiple cancers: a meta-analysis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014;35(6):5143-8.

Boyerinas B, Park SM, Hau A, Murmann AE, Peter ME. The role of let-7 in cell differentiation and cancer. Endocrine-related cancer. 2010;17(1):F19-36.

Park SM, Shell S, Radjabi AR, Schickel R, Feig C, Boyerinas B, et al. Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell cycle (Georgetown, Tex). 2007;6(21):2585-90.

Lamichhane SR, Thachil T, De Ieso P, Gee H, Moss SA, Milic N. Prognostic Role of MicroRNAs in Human Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Disease Markers. 2018;2018.

Hayes DF, Isaacs C, Stearns V. Prognostic factors in breast cancer: current and new predictors of metastasis. Journal of mammary gland biology and neoplasia. 2001;6(4):375-92.

Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer research. 2004;64(11):3753-6.

Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer cell. 2006;9(3):189-98.

Landi MT, Zhao Y, Rotunno M, Koshiol J, Liu H, Bergen AW, et al. MicroRNA expression differentiates histology and predicts survival of lung cancer. Clinical Cancer Research. 2010:1078-0432. CCR-09-1736.

Jusufović E, Rijavec M, Keser D, Korošec P, Sodja E, Iljazović E, et al. let-7b and miR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non–small–cell lung cancer. PloS one. 2012;7(9):e45577.

Voortman J, Goto A, Mendiboure J, Sohn JJ, Schetter AJ, Saito M, et al. MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non–small cell lung carcinoma. Cancer research. 2010;70(21):8288-98.

Yu S-L, Chen H-Y, Chang G-C, Chen C-Y, Chen H-W, Singh S, et al. MicroRNA signature predicts survival and relapse in lung cancer. Cancer cell. 2008;13(1):48-57.

Xia X-M, Jin W-Y, Shi R-Z, Zhang Y-F, Chen J. Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer. Oncology letters. 2010;1(6):1045-8.

Zhu W-Y, Luo B, An J-y, He J-y, Chen D-d, Xu L-Y, et al. Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. Cancer investigation. 2014;32(8):394-401.

Zhang Y-K, Zhu W-Y, He J-Y, Chen D-D, Huang Y-Y, Le H-B, et al. miRNAs expression profiling to distinguish lung squamous-cell carcinoma from adenocarcinoma subtypes. Journal of cancer research and clinical oncology. 2012;138(10):1641-50.

Yu H, Guan Z, Cuk K, Brenner H, Zhang Y. Circulating microRNA biomarkers for lung cancer detection in Western populations. Cancer medicine. 2018;7(10):4849-62.

Lee YS, Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes & development. 2007;21(9):000-.

Boyerinas B, Park S-M, Shomron N, Hedegaard MM, Vinther J, Andersen JS, et al. Identification of let-7–regulated oncofetal genes. Cancer research. 2008;68(8):2587-91.

Boyerinas B, Park S-M, Hau A, Murmann AE, Peter ME. The role of let-7 in cell differentiation and cancer. Endocrine-related cancer. 2010;17(1):F19-F36.

Shen J, Todd NW, Zhang H, Yu L, Lingxiao X, Mei Y, et al. Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. Laboratory investigation. 2011;91(4):579.

Bishop JA, Benjamin H, Cholakh H, Chajut A, Clark DP, Westra WH. Accurate classification of non–small cell lung carcinoma using a novel microRNA-based approach. Clinical Cancer Research. 2010:1078-0432. CCR-09-2638.


Refbacks

  • There are currently no refbacks.