Introduction: Infertility affects an estimated 15% of couples globally and in Iran, a quarter of Introduction: One of the current debates regarding men’s reproductive health is the declining sperm count and the role of nutritional and environmental factors. This study aims to investigate the association between dairy product consumption and oligozoospermia, sperm count of 5 to 15 million per milliliter of semen, in adult men.
Materials and Methods: This age-matched case-control study was conducted on 102 oligozoospermia and 306 healthy men (control group). Both groups were recruited from an infertility clinic in Tehran, the Royan Institute. Dietary intake of subjects was collected using a valid and reliable 168-item food frequency questionnaire. Odds ratios (OR), ex-tracted from conditional logistic regression, were used to compare the occurrence of oligozoospermia by tertiles of dairy intake.
Results: After adjusting for potential confounding variables, the high intake of low-fat dairy products was inversely associated with the risk of oligozoospermia (OR: 0.48; 95%CI: 0.24 – 0.95), (P =0.046). The higher intake of high–fat dairy products [(OR: 2.44; 95%CI: 1.26 – 4.73), (P =0.008)], high–fat milk [(OR: 2.16; 95%CI: 1.09 – 4.30), (P =0.043)], and ice creams [(OR: 2.37; 95%CI: 1.25 – 4.50), (P =0.008)] were also positively associated with oligozo-ospermia.
Conclusion: The high intake of low–fat dairy foods seems to have a protective effect on oligozoospermia. Higher intake of high – fat dairy products, high– fat milk, and ice creams were associated with an increased risk of oligozo-ospermia.
Wilkes, S., et al., Epidemiology and management of infertility: a population-based study in UK primary care. Family practice, 2009. 26(4): p. 269-274.
Akhondi, M.M., et al., Prevalence of primary infertility in Iran in 2010. Iranian journal of public health, 2013. 42(12): p. 1398.
Safarinejad, M.R., Infertility among couples in a population‐based study in Iran: prevalence and associated risk factors. International journal of andrology, 2008. 31(3): p. 303-314.
Forti, G. and C. Krausz, Evaluation and treatment of the infertile couple. The Journal of Clinical Endocrinology & Metabolism, 1998. 83(12): p. 4177-4188.
Lackner, J., et al., Constant decline in sperm concentration in infertile males in an urban population: experience over 18 years. Fertility and sterility, 2005. 84(6): p. 1657-1661.
Cooper, T.G., et al., World Health Organization reference values for human semen characteristics. Human reproduction update, 2010. 16(3): p. 231-245.
Gaskins, A.J., et al., Physical activity and television watching in relation to semen quality in young men. Br J Sports Med, 2013: p. bjsports-2012-091644.
Sermondade, N., et al., BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human reproduction update, 2012. 19(3): p. 221-231.
Attaman, J.A., et al., Dietary fat and semen quality among men attending a fertility clinic. Human Reproduction, 2012. 27(5): p. 1466-1474.
Alvarez-León, E.-E., B. Román-Vinas, and L. Serra-Majem, Dairy products and health: a review of the epidemiological evidence. British Journal of Nutrition, 2006. 96(S1): p. S94-S99.
Afeiche, M., et al., Dairy food intake in relation to semen quality among active young men. Fertility and Sterility, 2012. 98(3): p. S41.
Vujkovic, M., et al., Associations between dietary patterns and semen quality in men undergoing IVF/ICSI treatment. Human Reproduction, 2009. 24(6): p. 1304-1312.
Afeiche, M.C., et al., Dairy intake and semen quality among men attending a fertility clinic. Fertility and sterility, 2014. 101(5): p. 1280-1287. e2.
Mirmiran, P., et al., Reliability and relative validity of an FFQ for nutrients in the Tehran Lipid and Glucose Study. Public health nutrition, 2010. 13(5): p. 654-662.
Asghari, G., et al., Reliability, comparative validity and stability of dietary patterns derived from an FFQ in the Tehran Lipid and Glucose Study. British journal of nutrition, 2012. 108(6): p. 1109-1117.
Bowman, S.A., J.E. Friday, and A.J. Moshfegh, MyPyramid equivalents database, 2.0 for USDA survey foods, 2003-2004: Documentation and user guide. US Department of Agriculture, 2008.
Mendiola, J., et al., Food intake and its relationship with semen quality: a case-control study. Fertility and sterility, 2009. 91(3): p. 812-818.
Alcock, R.E., et al., Dioxin-like PCBs in the environment-human exposure and the significance of sources. Chemosphere, 1998. 37(8): p. 1457-1472.
Damgaard, I.N., et al., Impact of exposure to endocrine disrupters inutero and in childhood on adult reproduction. Best practice & research Clinical endocrinology & metabolism, 2002. 16(2): p. 289-309.
Joensen, U.N., et al., Do perfluoroalkyl compounds impair human semen quality? Environmental health perspectives, 2009. 117(6): p. 923.
Richthoff, J., et al., Serum levels of 2, 2', 4, 4', 5, 5'-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population. Environmental health perspectives, 2003. 111(4): p. 409.
Hoppe, C., et al., High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. European Journal of Clinical Nutrition, 2004. 58(9): p. 1211.
Hoppe, C., et al., High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year old boys. European Journal of Clinical Nutrition, 2005. 59(3): p. 393.