Teratoma in Infants and Children

Fathollah Roshanzamir, Javad Ghoroubi, Alireza Mirshemirani, Ahmad Khaleghnejad Tabari, Mohsen Rouzrokh, Mehrdad Izadi, Leili Mohajerzadeh, Alireza Mahdavi, Mehdi Sarafi

Abstract


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Background: Teratomas arise from three germ cell layers, the ectoderm, endoderm and mesoderm1, 2, and have several degrees of differentiation. We report our experience with teratomas at a tertiary pediatric surgery center.

Patients and Methods: The hospital records of all patients with the pathological diagnosis of teratoma treated during 10 years between 2004 and 2014 were reviewed and the following information was obtained: Sex, site of tumor, treatment and outcome.

Results: Sixty seven patients consisting of 49 girls (73%) and 18 boys (27%) were treated with teratomas at various sites of the body. These included: sacrococcygeal (SC) 32 patients (27 females& 5 males), ovarian 12 cases, cervical 4 patients (1 females & 3 males), retroperitoneal 9 (5 females & 4 males), Nasopharyngeal 2 patients both of which were females, mediastinal 2 cases (1 female & 1 male) and 5 testicular teratoma patients. All patients underwent surgery, and the most common procedure was total resection in 63(94%) of patients. Twenty eight (42%) received chemotherapy. In follow-up 52(77%) patients were in complete remission, 8(12%) had died, and 4 cases did not attend follow-up visits.

Conclusions: Teratomas are a group of tumors with similar histological picture but different behaviors. Sacrococcygeal teratomas are the commonest and the majorities are benign but the risk of malignant transformation increases with age. Management of teratomas is a combination of surgery and chemotherapy which may lead patients to a better prognosis.


Keywords


Teratoma; Germcell tumor; Children

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References


Ashley DJB: Origin of teratomas. Cancer 1973; 32:390-394.

Tapper D, Lack EE: Teratomas in infancy and childhood: a 54- year experience at the children’s Hospital Medical Center. Ann Surg 1983; 198:398-410.

Grosfeld JL, Ballantine TV, Lowe D, et al: Benign and malignant teratomas in children: Analysis of 85 patients. Surgery 1976; 80:297-305.

Bjornsson J, Scheithquer BW, Okazaki H, et al: Intracranial germ cell tumors: pathological and immune-histochemical aspects of 70 cases. J NeuropatholExpNeurol 1985; 44:32-36.

Gupta DK, Srinivas M, Dave S, et al: Gastric teratoma in children. PediatrSurgInt 2000; 16: 329-323.

Berry CL, Keeling J, Hilton C: Teratomas in infancy and childhood: a review of 91 cases. J Path 1969; 98:241-252.

Jamal AAS, Mansoor I, Altaf FJ, et al: Clinicopathological features of immature neck teratoma. Annals of Saudi Medicine 2001; 21:77-78.

Gabra HO, Jesudason EC, McDowell HP, et al: Sacrococcygeal teratoma- A 25-year experience in a UK regional center. J Pediatr Surg 2006; 41:1513-1516.

Derikx JP, De Backer A, van de Schoot L, et al: Factors associated with recurrence and metastasis in sacrococcygeal teratoma. Br. J. Surg 2006; 93:1543-1548.

De Backer A, Maden GC, Hakvoort-cammel FG, et al: Study of the factors associated with recurrence in children with sacrococcygeal teratoma. J PediatrSurg 2006, 41:173-181.

Bittmann S, Bittmann V: Surgical experience and cosmetic outcomes in children with sacrococcygeal teratoma. CurrSurg 2006; 63:51-54.

Sebire NJ, Fowler D, Ramsay AD: Sacrococcygeal tumors in infancy and childhood: a retrospective histopathological review of 85 cases. Fetal PediatrPathol 2004; 23:295-303.

Rescola FJ, Sawin RS, Coran AG, et al: Long-term outcome for infants and children with sacrococcygeal teratoma: a report from the Children Cancer Group. J PediatrSurg 1998; 33:171-176.

Johnson N, Shah S, Shannon P, et al: A challenging delivery by EXIT procedure of a fetus with a giant cervical teratoma. J ObstetGynaecol Can 2009;31:267-271.

- Khaleghnejad A; Mirshemirani A; Rouzrokh M.et al: Pediatric germ cell tumors; A 10-year experience. Iran J Pediatr. 2014; 24(4): 441-444.

Chaudhary A, Misra S, Wakhula A, et al: Retroperitoneal teratomas in children. Indian J Pediatr 2006; 73:221-223.

Hart J, Mazrani W, Jones N, et al: Upper abdominal teratomas in infants: radiological findings and importance of vascular anatomy. PediatrRadiol 2008; 38:750-755.

Jones NM, Kiely EM: Retroperitoneal teratomas-potential for surgical misadventure. J PediatrSurg 2008;43:184-186.

- Mirshemirani A; Khaleghnejad A; Mohajerzadeh L. et al: Congenital nasopharyngeal teratomas in a neonate. Iran J Pediatr 2011; 21 (2):249-252.




DOI: https://doi.org/10.22037/irjps.v1i2.11532

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