Dose Supplemental Zinc Prevent Recurrence of Febrile Seizures?

Siamak SHIVA, Mohammad BARZEGAR, Nona ZOKAIE, Shadi SHIVA



How to Cite this Article: Shiva S, Barzegar M, Zokaie N, Shiva Sh. Dose Supplemental Zinc Prevents Recurrence of Febrile Seizures? Iranian Journal ofChild Neurology 2011;5(4):11-14.



Febrile seizures (FS) are the most common form of seizures in children. Previous studies have suggested that zinc may play a role in the prevention of FS. However, there is limited information on the preventative effects of zinc against FS. This study aimed to determine whether prescribing zinc supplements could prevent FS.

Materials & Methods

In a randomized, placebo-controlled trial, 100 children who had experienced simple FS for the first time were recruited. Children in the case group (50 patients) were orally administered1mg/kg/day zinc sulfate for 1 year, and children in the control group (50 patients) received a placebo. Serum zinc levels in both the control and case groups were measured at the start and at the end of the study,and recurrent cases of FS were recorded.


The case group consisted of 29 boys (58%) and 21 girls (42%) with a mean age of 2.06 ± 0.83, and the control group consisted of 31 boys (62%) and 19 girls (38%) with a mean age of 2.22 ± 1.04 years. An inverse relationship was found between febrile diseases and serum zinc levels. In other words, the occurrence of febrile diseases decreased with an increase in serum zinc levels.Eight children (16%) in the case group and 8 in the control group experienced recurrent FS within a year.


Supplemental doses of zinc (1mg/kg/day) reduced the rate of febrile illnesses,but did not prevent the recurrence of FS.


  1. Margaretha L, Masloman N. Correlation between serum zinc level and simple febrile seizure in children. Paediatr Indones 2010;50(6):326-30.
  2. Prasad R, Singh A, Das B, Upadhyay R, Singh T, Mishra O. Cerebrospinal fluid and serum zinc, copper, magnesium and calcium levels in children with Idiopathic seizure. J Clin Diagn Res 2009;3:1841-6.
  3. Vestergaard M, Obel C, Henriksen TB, Christensen J, Madsen KM, Østergaard JR, et al. The Danish National Hospital Register is a valuable study base for epidemiologic research in febrile seizures. J Clin Epidemiol 2006;59(1):61-6.
  4. Jensen FE, Sanchez RM. Why does the developing brain demonstrate heightened susceptibility to febrile and other provoked seizures. In: Baram TZ, Shinnar S, editors. Febrile seizures. San Diego: Academic Press; 2002. p.153-68.
  5. Bhandari N, Bahl R, Taneja S, Strand T, Mølbak K, Ulvik RJ, et al. Effect of routine zinc supplementation on pneumonia in children aged 6 months to 3 years: randomised controlled trial in an urban slum. Bmj.2002;324(7350):1358.
  6. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J clin nutr. 1998;68(2):447S.
  7. Burhanolu M, Tütüncüolu S, Coker C, Tekgül H, Ozgür T. Hypozincaemia in febrile convulsion. Eur J Pediatr 1996;155(6):498-501.
  8. Garty BZ, Olomucki R, Lerman-Sagie T, Nitzan M. Cerebrospinal fluid zinc concentrations in febrile convulsions. Arch Dis Child 1995;73(4):338-41.
  9. Löscher W, Rating D, Siemes H. GABA in cerebrospinal fluid of children with febrile convulsions. Epilepsia 1981;22(6):697-702.
  10. Raqib R, Roy SK, Rahman MJ, Azim T, Ameer SS, Chisti J, et al. Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. Am J Clin Nutr 2004;79(3):444-50.
  11. Ganesh R, Janakiraman L. Serum zinc levels in children with simple febrile seizure. Clinical pediatrics 2008;47(2):164.
  12. Gunduz Z, Yavuz I, Koparal M, Kumandas S, Saraymen R. Serum and cerebrospinal fluid zinc levels in children with febrile convulsions. Acta Paediatr Jpn 1996;38(3):237-41.
  13. Mollah MA, Rakshit SC, Anwar KS, Arslan MI, Saha N, Ahmed S, et al. Zinc concentration in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: findings from a prospective study in Bangladesh. Acta Paediatr 2008;97(12):1707-11.
  14. Berg AT, Shinnar S, Darefsky AS, Holford TR, Shapiro ED, Salomon ME, et al. Predictors of recurrent febrile seizures. A prospective cohort study. Arch Pediatr Adolesc Med 1997;151(4):371-8.
  15. El-Radhi AS. Lower degree of fever at the initial febrile convulsion is associated with increased risk of subsequent convulsions. Eur J Paediatr Neurol 1998;2(2):91-6.
  16. Barzegar Mohammad SB, Alizadeh M, Jouyban AA, Ghafari S. Preventive Effect of Phenobarbital on Seizure Recurrence in Acute Phase of Febrile Seizure in Children. Med J Tabriz Univ Med Sci 2009;31(3):13-7.
  17. Mahyar A, Rezaee M. Ferritin Level in Children with and Without Febrile Convulsion. Behbood 2006;10(3(30)):204-9.
  18. Razieh F, Akhavan Karbasi S. The relationship between paraclinical findings of first febrile seizure and recurrence biological basis of altered resistance to infection. Am J clin nutr. 1998;68(2):447S.
  19. Papierkowski A, Mroczkowska - Juchkiewicz A. Magnesium and zinc levels in blood serum and cerebrospinal fluid in children with febrile convulsions]. Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego 1999;6(33):138.
  20. Mahyar A, Ayazi P, Fallahi M, Javadi A. Correlation between serum selenium level and febrile seizures. Pediatr Neurol 2010;43(5):331-4.
  21. Tütüncüolu S, Kütükçüler N, Kepe L, Coker C, Berdeli A, Tekgül H. Proinflammatory cytokines, prostaglandins and zinc in febrile convulsions. Pediatr Int 2001;43(3):235-9.
  22. Mollah MA, Dey PR, Tarafdar SA, Akhter S, Ahmed S, Hassan T, et al. Zinc in CSF of patients with febrile convulsion. Indian J Pediatr 2002;69(10):859-61.
  23. Kumar L, Chaurasiya OS, Gupta AH. Prospective Study of Level of Serum Zinc In Patients of Febrile Seizures,Idiopathic Epilepsy and CNS Infections. People J Sci Res 2011; 4(2):1-4.
  24. Schmiegelow K, Johnsen AH, Ebbesen F, Mortensen T, Berg AM, Thorn I, et al. Gamma-aminobutyric acid concentration in lumbar cerebrospinal fluid from patients with febrile convulsions and controls. Acta Paediatr Scand 1990;79(11):1092-8.
  25. Audenaert D, Schwartz E, Claeys KG, Claes L, Deprez L, Suls A, et al. A novel GABRG2 mutation associated with febrile seizures. Neurology 2006;67(4):687-90.



Seizures; febrile; child; prevention and control

Full Text:





  • There are currently no refbacks.

Copyright (c)