Exosome Therapy in Spinal Cord Injury: A Review

Shahrokh Khoshsirat, Aliasghar Keramatinia, Maryam Sadat Khoramgah, Saeed Vafaei-Nezhad, Somayeh Niknazar, Shahram Darabi, Foozhan Tahmasebinia, Hassan Peyvandi, Hojjat-Allah Abbaszadeh



Background: Injuries to the spinal cord (SCI) are one of the most detrimental central nervous system (CNS) injuries in developing countries. Today, treatment is one of the major issues facing the medical profession, and to date, there is no known promising treatment capable of fully healing injuries. There are various methods to repair and improve SCI, including the use of stem cells particularly mesenchymal stem cells (MSCs). Various studies have been performed on applying these cells in the treatment of SCI, whose results have confirmed the efficacy of using these cells specifically due to the paracrine secretion of these cells including growth factors, chemokines, cytokines, and small extracellular vesicles. Interestingly, among these paracrine molecules, exosomes may have the maximum therapeutic value and as such is widely investigated by researchers.

Aim: to fully focus on the usage of stem cell-derived extracellular vesicles on the healing of SCI in animal models.

Conclusion: Taken together, the extracellular nanovesicles have promising therapeutic potentials and their use in the treatment of SCI has been rapidly growing. In this review, we elucidated the effect of exosomes derived from bone marrow MSCs in SCI.


Exosome; Spinal Cord Injury; Mesenchymal stem cells

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DOI: https://doi.org/10.22037/orlfps.v5i2.28004


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