Evaluation of the effectiveness of 6-week vitamin D treatment in children aged 5 to 15 years with vitamin D insufficiency
Student Research in Translational Medicine,
Vol. 3 No. 4 (2021),
31 Dey 2021
,
Page 8-14
https://doi.org/10.22037/smsj.v3i4.36422
Abstract
Background: Vitamin D insufficiency is a common disorder worldwide and children are involved in this disorder. In this study, we aimed to evaluate the effectiveness of vitamin D insufficiency treatment with vitamin D 50,000 IU in children who had vitamin D insufficiency.
Methods: Children’s vitamin D levels were evaluated and if they had vitamin D insufficiency, one pearl of vitamin D 50,000 IU was prescribed weekly for 6 weeks, and after 6 weeks, vitamin D levels were checked again. Then all data were analyzed by SPSS software version 20.
Results: In this study, 97 children were evaluated and 61.9% were boys. The average age of children was 101.01 ± 19.27 months. The average BMI of these children was 15.46 ± 2.52 kg/m2. The initial vitamin D level was 18.21 ± 6.42 ng / mL with a range of 4.2 to 29.8. After treatment, this level reached 41.08 ± 14.61ng / mL (12.2 - 98.4 ng / mL) and this increase was statistically significant (P-value< 0.005). There was no correlation between age, gender, height, and BMI with the increased efficacy of vitamin D level with one pearl of vitamin D 50000 unit.
Conclusion: Using one pearl of vitamin D 50000 IU weekly for 6 weeks is a good method for vitamin D insufficiency treatment in children.
- Vitamin D, insufficiency, children, vitamin D effectiveness
How to Cite
References
Neyestani TR, Hajifaraji M, Omidvar N, Eshraghian MR, Shariatzadeh N, Kalayi A, et al. High prevalence of vitamin D deficiency in school-age children in Tehran, 2008: a red alert. Public health nutrition. 2012;15(2):324-30.
Zhu Z, Zhan J, Shao J, Chen W, Chen L, Li W, et al. High prevalence of vitamin D deficiency among children aged 1 month to 16 years in Hangzhou, China. BMC public health. 2012;12:126.
Gallagher JC, Sai AJ. Vitamin D insufficiency, deficiency, and bone health. The Journal of clinical endocrinology and metabolism. 2010;95(6):2630-3.
Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D, Calcium. The National Academies Collection: Reports funded by National Institutes of Health. In: Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US)
Copyright © 2011, National Academy of Sciences.; 2011.
Won JW, Jung SK, Jung IA, Lee Y. Seasonal Changes in Vitamin D Levels of Healthy Children in Mid-Latitude, Asian Urban Area. Pediatr Gastroenterol Hepatol Nutr. 2021;24(2):207-17.
Braegger C, Campoy C, Colomb V, Decsi T, Domellof M, Fewtrell M, et al. Vitamin D in the healthy European paediatric population. Journal of pediatric gastroenterology and nutrition. 2013;56(6):692-701.
Holick MF. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Molecular aspects of medicine. 2008;29(6):361-8.
Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. The American journal of clinical nutrition. 2008;87(4):1080s-6s.
Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2009;20(11):1807-20.
Samuel TM, Zhou Q, Giuffrida F, Munblit D, Verhasselt V, Thakkar SK. Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors. Frontiers in nutrition. 2020;7:576133.
Haimi M, Kremer R. Vitamin D deficiency/insufficiency from childhood to adulthood: Insights from a sunny country. World journal of clinical pediatrics. 2017;6(1):1-9.
Mellati AA, Sharifi F, Faghihzade S, Mousaviviri SA, Chiti H, Kazemi SA. Vitamin D status and its associations with components of metabolic syndrome in healthy children. Journal of pediatric endocrinology & metabolism : JPEM. 2015;28(5-6):641-8.
Gordon CM, Williams AL, Feldman HA, May J, Sinclair L, Vasquez A, et al. Treatment of hypovitaminosis D in infants and toddlers. The Journal of clinical endocrinology and metabolism. 2008;93(7):2716-21.
Olang B, Naghavi M, Bastani D, Strandvik B, Yngve A. Optimal vitamin A and suboptimal vitamin D status are common in Iranian infants. Acta paediatrica (Oslo, Norway : 1992). 2011;100(3):439-44.
van Schoor NM, Lips P. Worldwide vitamin D status. Best practice & research Clinical endocrinology & metabolism. 2011;25(4):671-80.
Tannous P, Fiscaletti M, Wood N, Gunasekera H, Zurynski Y, Biggin A, et al. Safety and effectiveness of stoss therapy in children with vitamin D deficiency. Journal of paediatrics and child health. 2020;56(1):81-9.
Won JW, Jung SK, Jung IA, Lee Y. Seasonal Changes in Vitamin D Levels of Healthy Children in Mid-Latitude, Asian Urban Area. Pediatr Gastroenterol Hepatol Nutr. 2021;24(2):207-17.
Zakharova I, Klimov L, Kuryaninova V, Nikitina I, Malyavskaya S, Dolbnya S, et al. Vitamin D Insufficiency in Overweight and Obese Children and Adolescents. Front Endocrinol (Lausanne). 2019;10:103-.
Marwaha RK, Mithal A, Bhari N, Sethuraman G, Gupta S, Shukla M, et al. Supplementation with Three Different Daily Doses of Vitamin D3 in Healthy Pre-pubertal School Girls: A Cluster Randomized Trial. Indian pediatrics. 2018;55(11):951-6.
Shepherd D, Belessis Y, Katz T, Morton J, Field P, Jaffe A. Single high-dose oral vitamin D3 (stoss) therapy--a solution to vitamin D deficiency in children with cystic fibrosis? Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2013;12(2):177-82.
Hocaoğlu-Emre FS, Sarıbal D, Oğuz O. Vitamin D Deficiency and Insufficiency According to the Current Criteria for Children: Vitamin D Status of Elementary School Children in Turkey. Journal of clinical research in pediatric endocrinology. 2019;11(2):181-8.
Hradsky O, Soucek O, Maratova K, Matyskova J, Copova I, Zarubova K, et al. Supplementation with 2000 IU of Cholecalciferol Is Associated with Improvement of Trabecular Bone Mineral Density and Muscle Power in Pediatric Patients with IBD. Inflammatory bowel diseases. 2017;23(4):514-23.
Zhang X, Chen Y, Jin S, Bi X, Chen D, Zhang D, et al. Association of serum 25-Hydroxyvitamin D with Vitamin D intervention and outdoor activity among children in North China: an observational study. BMC pediatrics. 2020;20(1):542.
- Abstract Viewed: 142 times
- PDF Downloaded: 65 times
