Evaluation of surface expression of platelet markers and left ventricle ejection fraction in patients with coronary artery disease
Student Research in Translational Medicine,
Vol. 3 No. 2 (2021),
1 June 2021
https://doi.org/10.22037/smsj.v3i2.30452
Abstract
Background and Aims: Surface expression of platelet markers enhanced during ischemic events and appear to play an important role in myocardial repair. Stromal cell-derived factor-1 (SDF-1) is one of these factors which its effects Mediated through CXCR4 and CXCR7 receptors. In our study we are going to determine the the surface expressions of platelet markers and the changes of left ventricle ejection fraction in patients with coronary artery disease.
Materials and Methods: This descriptive cross-sectional study measured the superficial expression of platelet indices (SDF-1R, CXCR4, and CXCR7) and its association with the changes of the left ventricle ejection fraction in patients with coronary artery disease who have referred to Taleghani Hospital, Tehran in 2016-2018.
Results: Among all patients referred to Taleghani Hospital with symptoms of coronary artery disease, 57 patient had inclusion criteria. this study demonstrated that mean SDF1 and CXCR4 level were respectively 1.1 and 2.3 which there were significant difference between those with severe EF reduction comparing to the rest of the groups (respectively P<0.002 & P<0.004 ). The mean CXCR7 value of all patients was 3.5 (SD= 0.27) and showed a significant difference in patients with severe (6) and low (4.7) ejection fraction reductions compared to those with moderate (2.5) and normal (2.8) ejection fraction reductions (P<0.009).
- Platelet markers
- Ejection Fraction
- Coronary artery disease
How to Cite
References
Corash L, Tan H, Gralnick HR. Heterogeneity of human whole blood platelet subpopulations. Relationship between buoyant density, cell volume, and ultrastructure. Blood. 1977;49(1):71-87.
Yamaguchi J, Kusano KF, Masuo O, Kawamoto A, Silver M, Murasawa S, Bosch-Marce M, Masuda H, LosordoDW, Isner JM, Asahara T. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 2003; 107:1322–1328.
Geisler T, Fekecs L, Wurster T, Chiribiri A, Schuster A, Nagel E, Miller S, Gawaz M, Stellos K, Bigalke B. Association of platelet-SDF-1 with hemodynamic function and infarct size using cardiac MR in patients with AMI. Eur J Radiol 2012;81:e486–e490.
Zhang D, Fan GC, zhou X, Zhao T, Pasha Z, Xu M, Zhu Y, Ashraf M,Wang Y. Overexpression ofCXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J Mol Cell Cardiol 2008;44:281–292.
Hu X, Dai S, Wu WJ, TanW, Zhu X, Mu J, Guo Y, Bolli R, Rokosh G. Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation 2007;116:654–663.
Lazarini F, Casanova P, Tham TN, De Clercq E, Arenzana-Seisdedos F, Baleux F, Dubois-Dalcq M. Differential signalling of the chemokine receptor cxcr4 by stromal cell-derived factor 1 and the hiv glycoprotein in rat neurons and astrocytes. Eur J Neurosci 2000;12:117–125.
Wegner SA, Ehrenberg PK, Chang G, Dayhoff DE, Sleeker AL, MichaelNL.Genomic organization and functional characterization of the chemokine receptor cxcr4, a major entry coreceptor for human immunodeficiency virus type 1. J Biol Chem 1998;273:4754–4760.
Sierro F, Biben C, Martı´nez-Mun˜oz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci USA 2007;104:14759–14764.
Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, Wei K, McMaster BE, Wright K, Howard MC, Schall TJ. A novel chemokine receptor for sdf-1 and i-tac involved in cell survival, cell adhesion, and tumor development. J Exp Med 2006;203:2201–2213
Martinez A, Kapas S, Miller MJ,Ward Y, Cuttitta F. Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells. Endocrinology 2000;141:406–411.
Lang RM, Badano LP, Mor-Avi Victor, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015;28:1.
Kiani AA, Babaei F, Sedighi M, Soleimani A, Ahmadi K, Shahrokhi S, et al. CXCR4 expression is associated with time–course permanent and temporary myocardial infarction in rats. Iran J Basic Med Sci. 2017 Jun; 20(6): 648–654.
Mayorga ME, Kiedrowski M, McCallinhart P, Forudi F, Ockunzzi J, Weber K, Chilian W, Penn MS, Dong F. Role of SDF-1:CXCR4 in Impaired Post-Myocardial Infarction Cardiac Repair in Diabetes. Stem Cells Transl Med. 2018 Jan;7(1):115-124.
Schiller NB, Shah PN, Crawford M. Recommendations.for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 1989; 2: 258– 267.
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