Pituitary Adenoma characteristics in patients referred to Loghman Hospital in seven years
School of Medicine Students' Journal,
Vol. 3 No. 3 (2021),
7 September 2021
https://doi.org/10.22037/smsj.v3i3.35342
Abstract
Background and aim:
The classification of pituitary adenomas now includes an "atypical" variant, which can be defined as MIB-1 proliferative index greater than 3%, excessive p53 immunoreactivity, invasive growth pattern, and increased mitotic activity. In this study, we aimed to describe pituitary adenoma characteristics in patients referred to the Loghman Hakim hospital.
Methods:
This article is a cross-sectional descriptive study. In this study, the authors reviewed the records of 300 patients, including 250 patients with typical pituitary adenoma and 50 patients with atypical pituitary who were referred to Loghman Hakim Hospital between 2011 and 2017. Statistical analyses were performed using Fisher's exact test and Mann-Whitney.
Result:
In the APAs group, 47.8% and 52.2% of the tumors were microadenomas and macroadenomas, respectively. In the APA group, 91.3% of the patients had a Ki-67 labeling index of more than 3%, and the presence of p53 protein was observed in all the patients with APAs. The mean number of mitosis in the TPAs and APAs groups was 0.62 and 2.5, respectively. In addition, our results showed significant threshold values for mitotic index (>2 mitosis within ten high power fields). Also, there was no significant difference between the size of tumors and the type of secretion hormones in the APA and TPA groups (P> 0.05).
Conclusion:
There was a relationship between tumor size and hormone secretion with types of pituitary adenoma.
- Adenoma
- Pituitary Neoplasms
- Tumor Suppressor Protein p53
- Mitotic Index
- Ki-67 Antigen
- MIB-1 antibody
How to Cite
References
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