A Rare Case Report of Duodenal Adenocarcinoma Accompanied by Cerebellar Medulloblastoma
School of Medicine Students' Journal,
Vol. 2 No. 2 (2020),
2 May 2020
A case of a 6-year-old female with a diagnosis of Duodenal Adenocarcinoma is presented by the authors, in which 24 months subsequent to undergoing radiation therapy for a Cerebellar Medulloblastomas, the mentioned diagnosis has been confirmed. Although, the chance of a secondary malignancy has been recognized to be elevated in children formerly undergone radiation therapy, the incidence of duodenal adenocarcinoma is a highly infrequent condition. As a consideration, observing manifestations like weight loss, vomiting, and icterus in a pediatric patient who has been administered earlier on with radiation therapy, must alert physicians that the risk of a gastrointestinal malignancy exists.
How to Cite
Rossi A, Caracciolo V, Russo G, Reiss K, Giordano A. Medulloblastoma: from molecular pathology to therapy. Clin Cancer Res. 2008;14(4):971-6.
Vermeulen JF, van Hecke W, Spliet WG, Villacorta Hidalgo J, Fisch P, Broekhuizen R, et al. Pediatric Primitive Neuroectodermal Tumors of the Central Nervous System Differentially Express Granzyme Inhibitors. PLoS One. 2016;11(3):e0151465.
Thomas A, Noël G. Medulloblastoma: optimizing care with a multidisciplinary approach. J Multidiscip Healthc. 2019;12:335-47.
Aparicio T, Zaanan A, Svrcek M, Laurent-Puig P, Carrere N, Manfredi S, et al. Small bowel adenocarcinoma: epidemiology, risk factors, diagnosis and treatment. Dig Liver Dis. 2014;46(2):97-104.
Chen EY, Vaccaro GM. Small Bowel Adenocarcinoma. Clin Colon Rectal Surg. 2018;31(5):267-77.
Tian J, Liu J, Guo C, Yang X, Yang Y, Gou H, et al. Prognostic factors and treatment outcomes in patients with non-ampullary small bowel adenocarcinoma: Long-term analysis. Medicine (Baltimore). 2019;98(17):e15381.
Dracham CB, Shankar A, Madan R. Radiation induced secondary malignancies: a review article. Radiat Oncol J. 2018;36(2):85-94.
Ng AK, Kenney LB, Gilbert ES, Travis LB. Secondary malignancies across the age spectrum. Semin Radiat Oncol. 2010;20(1):67-78.
Gibbs IC, Tuamokumo N, Yock TI. Role of radiation therapy in pediatric cancer. Hematol Oncol Clin North Am. 2006;20(2):455-70.
Zhuge Y, Cheung MC, Yang R, Eldick D, Koniaris LG, Sola JE. Pediatric intestinal foregut and small bowel solid tumors: a review of 105 cases. J Surg Res. 2009;156(1):95-102.
Mudie NY, Swerdlow AJ, Higgins CD, Smith P, Qiao Z, Hancock BW, et al. Risk of second malignancy after non-Hodgkin's lymphoma: a British Cohort Study. J Clin Oncol. 2006;24(10):1568-74.
Paulino AC, Fowler BZ. Secondary neoplasms after radiotherapy for a childhood solid tumor. Pediatr Hematol Oncol. 2005;22(2):89-101.
Densmore TL, Langer JC, Molleston JP, Dehner LP, Coffin CM. Colorectal adenocarcinoma as a second malignant neoplasm following Wilms' tumor and rhabdomyosarcoma. Med Pediatr Oncol. 1996;27(6):556-60.
Kimball Dalton VM, Gelber RD, Li F, Donnelly MJ, Tarbell NJ, Sallan SE. Second malignancies in patients treated for childhood acute lymphoblastic leukemia. J Clin Oncol. 1998;16(8):2848-53.
Prabakaran S, Senthilnathan SV, Venkatadesikalu M, Prasad N, Sridharan S. Adenocarcinoma of the colon as a second malignancy in a child. Pediatric Surgery International. 2001;17(5):475-7.
Park SS, Kim BK, Kim CJ, Kim WS, Kim IO, Park KW, et al. Colorectal adenocarcinoma as a second malignant neoplasm following rhabdomyosarcoma of the urinary bladder: a case report. J Korean Med Sci. 2000;15(4):475-7.
Kalteis T, Heers G, Elsner R. Adenocarcinoma of the rectum in childhood following chemotherapy and radiotherapy for a rhabdomyosarcoma--a case report. Eur J Pediatr Surg. 2005;15(3):210-2.
Turcot J, Despres JP, St Pierre F. Malignant tumors of the central nervous system associated with familial polyposis of the colon: report of two cases. Dis Colon Rectum. 1959;2:465-8.
Hamilton SR, Liu B, Parsons RE, Papadopoulos N, Jen J, Powell SM, et al. The molecular basis of Turcot's syndrome. N Engl J Med. 1995;332(13):839-47.
Ladd AP, Grosfeld JL. Gastrointestinal tumors in children and adolescents. Semin Pediatr Surg. 2006;15(1):37-47.
- Abstract Viewed: 75 times
- PDF Downloaded: 40 times