The Effects of Aerobic Exercise on NF-κB and TNF-α in Lung Tissue of Male Rat
Novelty in Biomedicine,
Vol. 3 No. 3 (2015),
22 July 2015
,
Page 131-134
https://doi.org/10.22037/nbm.v3i3.8001
Abstract
Background:Regular aerobic exercise improves the
Background: Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the lung response have not been investigated. The present study evaluated the effect of aerobic exercise on the lung inflammatory.Materials and Methods: 12 adult male Wistar rats were divided to 2 groups: A: control (n=6), B: aerobic exercise (five times per week for 4 week; n=6). The gene expression of NF-κB and TNF-α were analyzed in lung tissue by Real time–PCR. In order to determine the significant differences between groups independent t-test were used.
Results: Aerobic exercise inhibited the gene expression of NF-κB and TNF-α. But there was no significant difference between A and B groups for TNF-α and NF-κB.
Conclusion: We conclude that four week aerobic exercise decrease inflammatory status in lung tissue. Our results indicate a need for human studies that evaluate the lung responses to aerobic exercise.
- aerobic exercise
- inflammation
- lung tissue
How to Cite
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