Novelty in Biomedicine

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Yan H, Jiang D, Gehyung-Jun Im Z, England C, Peng H, Fan C, et al (2018) DNA origami nanostructures for treatment of acute kidney injury. WO Patent 2018165465A1. Available from: https://patentscope.wipo.int/search/pt/detail.jsf;jsessionid=FB2172AB1874BF6015589406EC10B35B.wapp1nB?docId=WO2018165465&recNum=330&office=&queryString=&prevFilter=%26fq%3DOF%3AWO%26fq%3DICF_M%3A%22A61K%22&sortOption=Data+pub+ordem+inversa&maxRec=185550

Yan H, Jiang Q, Li S, Ding B, Nie G (2019) DNA nanorobot and methods of use thereof. WO Patent 2019109707A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019109707

Rus D, Miyashita S, Damain D (2017) Origami robots and systems. WO Patent 2017185003A1. Available from: https://patents.google.com/patent/US20170303965A1/en

Castro C, Lucas C, Halley P, Byrd J (2019) Multi-functional cancer drug delivery nanodevice for precision medicine. W.O. Patent 2019199787A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019199787

Yan-Juan H, Jin-Caihong H (2015) Method for simulation of DNA nano origami structure as drug carrier by DAPI embedding and release. CN Patent 105004703A. Available from: https://patents.google.com/patent/CN105004703B/en

Zhang-Nan Z, Yīng-Tangyafang T (2017) A kind of construction method of accurate identification targeted nano carrier based on DNA paper folding arts and its application. CN Patent 107469088A. Available from: https://patents.google.com/patent/CN107469088A/en

Baoquan D, Shuai Z, Qiao J, Shaoli L (2019) Anticoagulation DNA nano composite structure and preparation method and application thereof. CN Patent 110551725A. Available from: https://patents.google.com/patent/CN105126716B/en

Xu H, Li Z, Si J. Nanocarriers in gene therapy: a review. J Biomed Nanotechnol 2014; 10(12): 3483-3507.

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Wang Y, Rajala A, Rajala RV. Lipid nanoparticles for ocular gene delivery. J Func Biomat 2015; 6(2): 379-394.

Mead BP, Mastorakos P, Suk JS, Klibanov AL, Hanes J, Price RJ. Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound. J Cont Rel 2016; 223: 109-117.

Chan F, Olivier H, Kiem H-P, Adaird JE, Rawlings D, Scharenberg A, Torgerson T (2018) In vivo gene therapy for immune deficiencies. WO Patent 2018152371. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018152371&_cid=P11-KYJI7X-95740-1

Cotney J, Kentros C, Blankvoort S, Raveendran Nair R (2019) Neuronal enhancers. US Patent 2019247516A1. Available from: https://www.freepatentsonline.com/y2019/0247516.html

Hagness S, Aiken E, Booske J, Sollinger H, Laeseke P, Alam T (2020) In vivo gene therapy delivery procedure and device. US Patent 2020030602A1. Available from: https://patents.justia.com/patent/20200030602

Staecker H, Liuz XZ, Chen HY, Ayala CJ (2018) Gene therapy constructs and methods for treatment of hearing loss. WO Patent 2018170402A1. Available from: https://www.freepatentsonline.com/y2020/0114023.html

Sullivan SM, Smith L, Clemente B, Wei Q, Ye M, Hayashi Y (2018) Lipid nanoparticle (lnp)-mediated delivery of a CRISPR-expressing plasmid DNA for treating chronic hepatitis b virus infection. WO Patent 2018237369A2. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018237369

Kotin RM, Kerr D, Samayoa P, Alkan O, Simmons MJ (2019) Gene editing using a modified closed-ended dna (ceDNA). WO Patent 2019113310A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019113310

Sadelain M, Cabriolu A (2019) Globin gene therapy for treating hemoglobinopathies. WO Patent 2019113321A1. Available from: https://patents.google.com/patent/EP3189143A4/en

Rodino-Klapac LR (2019) Gene therapy for limb-girdle muscular dystrophy type 2C. WO Patent 2019152474A1. Availabe from: https://patents.justia.com/patent/20200360534

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Shen J, Kelleher III RJ (2019) Gene therapy for alzheimer's disease. WO Patent 2019226832A1. Available from: https://www.google.com/patents/WO2000023587A2

Hatanaka F, Liao HK, Carlos J, Belmonte I (2019) Targeted gene activation using modified guide RNA. WO Patent 2019236081A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019236081

Sieving PA, Bush RA, Song H, Wei LL, Zeng Y, Wiley HE (2020) Intraocular delivery of gene therapy expression vectors. WO Patent 2020018766A1. Available from: https://patents.google.com/patent/WO2020018766A1/en

Huizhen J, Xuetan S, Wenguang L, Wei W (2019) Viroid gene-drug transmits nanocarrier and its preparation method and application altogether. CN Patent 109200294. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=CN236653194&_cid=P22-KYJSF5-66872-1

Qilong W, Li Z, Fengjuan Y (2018) The single stranded DNA aptamers of multidrug resistance colon cancer cell. CN Patent 1078 68786. https://patents.google.com/patent/CN107868786B/en

Schuh RS, Teixeira HF, Baldo G, Matte UDS, Giugliani R, Bidone J (2019) Composition for gene therapy of the central nervous system, process of production and use thereof. WO Patent 2019023770A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=EP296018984&docAn=18840364

Rezai MS, Rahimzadeh G, Gill P, Saeedi M (2019) Fabrication of phage nanobioparticles against burn wound methicillin-resistant staphylococcus aureus (MRSA) infections. WO Patent 2019162972 A1. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019162972

Gheibi Hayat SM, Darroudi M. Nanovaccine: a novel approach in immunization. J Cel Phys 2019; 234(8): 12530-12536.

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Kim MG, Park JY, Shon Y, Kim G, Shim G, Oh YK. Nanotechnology and vaccine development. Asian J Pharmaceut Sci 2014; 9(5): 227-235.

Gourapura R, Selvaraj R, Renu S (2019) Nanoparticle compositions for salmonella vaccines. WO Patent 2019035963A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019035963

Gourapura R, Dhakal S, Renu S (2019) Mucoadhesive nanoparticle entrapped influenza virus vaccine delivery system. WO Patent 2019108928A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019108928

Guo P, Li H, Khisamutdinov E, Jasinski D (2019) RNA-based compositions and adjuvants for prophylactic and therapeutic treatment. US Patent 10378018B2. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2015196146

Chang Y, Yan H, Hecht S, Pentel P, Liu X, Maini R (2015) Novel nicotine DNA vaccines. US Patent 2015017201A1. https://patents.google.com/patent/US20150017201A1/en

McLeod R, El-Bissati K, Zhou Y, Alexander J, Vang L, Reed S, et al (2019) Toxoplasma gondii vaccines and their use. US Patent 2019282679A1. https://patents.google.com/patent/WO2017184456A1/en

Baoquan D, Shaoli L, Qiao J (2019) A kind of DNA nano vaccine and its preparation method and application. CN Patent 110507817. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=CN279014406&_cid=P22-KYJT2J-73684-1

Vizzini P, Iacumin L, Comi G, Manzano M. Development and application of DNA molecular probes. AIMS Bioeng 2016; 4(11): 3-32.

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Dannong H, Shanshan Z, Ping W, Caihong J (2017) A kind of magnetic Nano treatment diagnostic reagent and preparation and application based on DNA materials. CN Patent 106492235. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=CN194484200&_cid=P22-KYJT9X-75860-1

Jiehua M, Chenbo J, Xirong G, Lianjun P, Pengfei X, Juan W, Juan X (2019) A kind of kit, detection method and its application of amido modified gold nanocarrier sense cell C/EBP α. CN Patent 110057799. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=CN250124566&_cid=P22-KYJTCF-76559-1

Jie J, Chunling W (2018) For diagnosing schizoid peripheral blood marker-plasma DNA. CN Patent 108277268. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=CN223925787&_cid=P22-KYJTEX-77446-1

Jianghui X, Fengji L, Ying C (2019) Diabetes diagnosis, the method for screening and risk profile, marker and kit. CN Patent 110223778. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=CN252149573&_cid=P22-KYJTHX-78367-1

Zhou F, Feng X, Chen L, Fu L (2020) Kit and method for detecting DNA. WO Patent 2020003087A1. Available from: https://patents.google.com/patent/WO2020003087A1/fr

Wang PH, Tu PA, Lai, FY, Shiau JW (2018) Method and kit for the field diagnosis of caprine arthritis-encephalitis virus (CAEV) infection. US Patent 10161012. Available from: https://patents.patsnap.com/v/US10161012-method-and-kit-for-the-field-diagnosis-of-caprine-arthritis-encephalitis-virus-caev-infection.html

Harvey J, Heller D, Jena P (2017) Sensors for nucleic acid biomarkers. WO Patent 2017177131A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2017177131

Bernert M, Weiss SFT, Letsolo BT (2019) A nanoparticle-based telomerase assay. WO Patent 2019116334A1. Available from: https://patentscope.wipo.int/search/en/detail.jsf;jsessionid=A5A75C922E658516D8A885FD42FED9FE.wapp2nC?docId=WO2019116334&recNum=11992&office=&queryString=&prevFilter=&sortOption=Pub+Date+Desc&maxRec=75495903

Gill P, Rafati A, Dorosti N (2020) Nanomolecular detection of aflatoxin B1. WO Patent 2020141498. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020141498

Rafati A, Dorosti N, Gill P. Smartphone-based technology for nanomolecular detection of aflatoxin B1 by aptamer-conjugated magnetic nanoparticles. World Mycotoxin J 2021. [In press]