Human Visceral Leishmaniasis: a Serological Survey in Rural Areas of Dashti District of Bushehr Province, Southern Iran
Novelty in Biomedicine,
Vol. 5 No. 2 (2017),
24 April 2017
AbstractBackground: Visceral leishmaniasis (VL) or kala-azar is a parasitic disease caused by the species of Leishmania donovani complex. Mediterranean type of the disease is endemic in some parts of Iran and more than 95% of cases were reported in children up to 12 years of age. This study was performed to determine the seroprevalence of VL in the rural areas of the Dashti district from Bushehr province.
Materials and Methods: In this cross-sectional study, a randomized cluster sampling method was used for the collection of blood samples from children up to 12 years old from rural areas of Dashti district. Before sampling; a questionnaire was filled out for each case. All the collected blood samples were examined after the serum separating by Direct Agglutination Test (DAT) for detection of anti-Leishmania infantum antibodies. The cutoff titers of ≥1: 3200 with specific clinical features were supposed to be considered as VL.
Results: Altogether, 24 out of 1221 (1.96%) blood samples showed titers between 1:800 and 1:1600 which considered as suspicious cases. None of the suspicious cases had a history of kala-azar. None of 1221 collected blood samples showed anti Leishmania infantum (L. infantum) at titer ≥1:3200.
Conclusion: This study confirms the circulation of L. infantum in Dashti district and highlights the sporadic pattern of VL in the studied areas which necessitates the surveillance system to be monitored by health authorities.
- Visceral leishmaniasis
- Direct Agglutination Test
How to Cite
Organization WH. International travel and health: situation as on 1 January 2010: World Health Organization; 2010.
Mohebali M. Visceral leishmaniasis in Iran: review of the epidemiological and clinical features. Iranian journal of parasitology. 2013;8(3):348.
Alvar J, Velez ID, Bern C, et al. Leishmaniasis worldwide and global estimates of its incidence. PloS one. 2012;7(5):e35671.
Mohebali M, Hajjaran H, Hamzavi Y. Epidemiological aspects of canine visceral leishmaniosis in the Islamic Republic of Iran. Veterinary parasitology. 2005;129(3):243-51.
EDRISIAN GH, Nadim A, Alborzi A, AREDEHALI S. Visceral leishmaniasis; the Iranian experience. 1998.
Ready PD. Epidemiology of visceral leishmaniasis. Clin Epidemiol. 2014;6(6):147-54.
Mahmoudvand H, Mohebali M, Sharifi I, et al. Epidemiological aspects of visceral leishmaniasis in Baft district, Kerman Province, Southeast of Iran. Iranian journal of parasitology. 2011;6(1):1.
Mohebali M, Edrissian G, Nadim A, et al. Application of direct agglutination test (DAT) for the diagnosis and seroepide-miological studies of visceral leishmaniasis in Iran. Iranian journal of parasitology. 2006;1(1):15-25.
Werneck GL. Visceral leishmaniasis in Brazil: rationale and concerns related to reservoir control. Revista de saude publica. 2014;48(5):851-6.
Mohebali M, Hamzavi Y, Edrissian GH, Forouzani A. Seroepidemiological study of visceral leishmaniasis among humans and animal reservoirs in Bushehr province, Islamic Republic of Iran. 2001.
el Harith A, Slappendel R, Reiter I, et al. Application of a direct agglutination test for detection of specific anti-Leishmania antibodies in the canine reservoir. Journal of clinical microbiology. 1989;27(10):2252-7.
Mohebali M, Edrissian GH, Shirzadi MR, et al. An observational study on the current distribution of visceral leishmaniasis in different geographical zones of Iran and implication to health policy. Travel medicine and infectious disease. 2011;9(2):67-74.
Abbaszadeh-Afshar M, Mohebali M, Sharifi I, et al. Seroepidemiological survey of Visceral leishmaniasis among nomadic tribes of Kerman Province, Southeastern Iran: An observational study for implication to health policy. Journal of Biostatistics and Epidemiology. 2015;1(2):105-11.
Harith A, Kolk A, Kager P, et al. A simple and economical direct agglutination test for serodiagnosis and sero-epidemiological studies of visceral leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1986;80(4):583-6.
Soleimanzadeh G, Edrissian GH, Movahhed-Danesh A, Nadim A. Epidemiological aspects of kala-azar in Meshkin-Shahr, Iran: human infection. Bulletin of the world health organization. 1993;71(6):759.
Fakhar M, Mohebali M, Barani M. Identification of Endemic Focus of Kala ـ azar and Seroepidemiologcial Study of Visceral Leishmania Infection in Human and Canine in Qom Province, Iran. Armaghane danesh. 2004;9(1):43-52.
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