Original Article / Research Article

Expression of Endothelial Nitric Oxide Synthase in Testicular Cells of Men with Obstructive Azoospermia; a Case-Control Study

Marefat Ghaffari Novin, Farhang Abed, Mohammad Ali Hosseini, Fatemeh Kiani, Khadijeh Foghi, Fereshte Aliakbari

Men's Health Journal, Vol. 1 No. 1 (2017), 1 July 2018, Page e3

Introduction: Obstructive azoospermia is one of the causes of post-testicular infertility in men and previous studies have reported inconsistent levels of endothelial nitric oxide synthase (eNOS) enzyme in these patients. Accordingly, the present study aimed to provide further evidence on the expression of eNOS enzyme in patients with azoospermia. Materials and Methods: In this case-control study, 10 patients, who were diagnosed with azoospermia and were referred to the infertility center for treatment or diagnosis, and 7 healthy fertile men were recruited. An informed written consent was obtained from included subjects and they underwent testicular biopsies. Samples were assessed via immunohistochemical methods to determine their levels of eNOS expression. 

Results: Both leydig and sertoli cells were found to express eNOS, while this enzyme was not expressed in normal germinal cells. The only significant difference between the two groups was the level of eNOS expression in sertoli cells which was found to be higher in patients with obstructive azoospermia compared to the control group (P<0.001). Conclusion: According to the results of this study, sertoli cells and their interactions with germinal cells of seminiferous tubule might play an important role in sperm quality and a subsequent successful fertilization.

Case Report

Adrenal Cavernous Hemangioma Associated with Myelolipoma; a Case Report

Mahsa Ahadi, Mohammad Esmaeil Akbari, Mitra Abdolahi, Mahsa Masoudnezhad, Afshin Moradi

Men's Health Journal, Vol. 1 No. 1 (2017), 1 July 2018, Page e2

Adrenal cavernous hemangioma is a rare benign tumor, most commonly diagnosed incidentally on imaging studies. Hereby we report a case of adrenal cavernous hemangioma with myelolipoma in a 39-year-old female presenting with epigastric pain for six months. CT scan of abdomen and pelvis showed a 38*27 mm left adrenal mass with heterogeneous enhancement and calcification. Laparoscopic left adrenalectomy was performed and pathologic examination grossly showed an encapsulated oval mass with multicystic cut surfaces containing hematoma. Microscopically, blood filled dilated vascular channels lined by endothelial cells with foci of adipose tissue admixed with normal hematopoietic cells were seen. Positive immunostaining for CD31 and CD34 confirmed the diagnosis of cavernous hemangioma. So, cavernous hemangioma associated with myelolipoma of the adrenal gland should always be considered as a differential diagnosis of adrenal masses.


Introduction word: Men’s Health Journal (MHJ)

Jalil Hosseini

Men's Health Journal, Vol. 1 No. 1 (2017), 1 July 2018, Page e1

Men's health is globally a relatively new debate that has attracted academic communities from the 1990s in identifying, preventing and treating specific conditions and men's common diseases. 

Considering the importance of men's health in accordance to policy makers’ and scientific communities’ opinion in different countries as a result of research development, publications and scientific productions in this field, it is necessary to publish the outcome of these researches and articles.

Thus, according to personal interest in the men's health and its foundation in Iran, as well as the main mission of our Research Center2 and the necessity of focusing different specialists on this issue, we decided to offer the Men's Health Journal. We hope by the participation of interested scientists and researchers in the field of Men’s health around the world, we will observe the wide contribution of different specialists who are interested in promoting men’s health in the world.