Investigating the Neurological Function and Anti-inflammatory Effects of Resveratrol in Rat Models with Spinal Cord Injury: A Systematic Review Protocol
Journal of Practical Emergency Medicine,
Vol. 12 No. 1 (2025),
1 Dey 2025
,
Page e5
https://doi.org/10.22037/jpem.v12i1.48694
Abstract
Background: Spinal cord injury (SCI) impairs sensory and motor functions, resulting in significant physical, psychological, and financial impacts. In Asia, SCI incidence ranges from 12.06 to 61.6 cases per million, lower than North America's 27.1 to 83.0 cases per million. Glucocorticoids like dexamethasone are used for SCI treatment but have limitations due to high-dose complications. Resveratrol, a polyphenol with antioxidative and anti-inflammatory properties, shows promise in central nervous system protection but requires further investigation for SCI.
Methods: This systematic review and meta-analysis follows PRISMA guidelines and is registered with PROSPERO (Code: CRD42024569681). It will assess resveratrol's effects on motor function (BBB/BMS score), anti-inflammatory proteins (IL-10, IL-6, TNF-α, IL-1β), and antioxidants (SOD, MDA, GSh) in SCI rat models. Searches will be conducted in PubMed/MEDLINE, Embase, Scopus, and Web of Science using relevant keywords, synonyms, MeSH, and EMTREE terms, including grey literature. Eligible studies will involve rats with traumatic SCI and resveratrol treatment, excluding combination therapies or different control groups. Two independent reviewers will screen and review studies, with a third reviewer resolving disagreements. Data will be extracted into an Excel sheet, covering study design, animal models, interventions, and outcomes. The SYRCLE tool will assess bias, and the GRADE scale will determine evidence certainty, with discrepancies resolved by discussion or third-party input.
Discussion: This review aims to elucidate resveratrol's potential to improve motor function and provide anti-inflammatory and antioxidant effects in SCI, potentially offering a non-toxic, cost-effective treatment option.
- Spinal Cord Injuries
- Acute Treatment
- Resveratrol
- Motor Function
How to Cite
References
Chen C, Qiao X, Liu W, Fekete C, Reinhardt JD. Epidemiology of spinal cord injury in China: a systematic review of the Chinese and English literature. Spinal Cord. 2022;60(12):1050-61.
Scivoletto G, Torre M, Mammone A, Maier DD, Weidner N, Schubert M, et al. Acute traumatic and ischemic spinal cord injuries have a comparable course of recovery. Neurorehabil Neural Repair. 2020;34(8):723-32.
Li H, Wang C, He T, Zhao T, Chen Y-y, Shen Y-l, et al. Mitochondrial transfer from bone marrow mesenchymal stem cells to motor neurons in spinal cord injury rats via gap junction. Theranostics. 2019;9(7):2017.
Lv R, Du L, Zhang L, Zhang Z. Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO-1 pathway. Life Sci. 2019;217:119-27.
Tang S, Botchway BOA, Zhang Y, Wang X, Huang M, Liu X. Resveratrol can improve spinal cord injury by activating Nrf2/HO-1 signaling pathway. Ann Anat. 2024;251:152180.
Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J. Anti-inflammatory action and mechanisms of resveratrol. Molecules. 2021;26(1):229.
Tian B, Liu J. Resveratrol: a review of plant sources, synthesis, stability, modification and food application. J Sci Food Agric. 2020;100(4):1392-404.
Olivares-Marin IK, González-Hernández JC, Madrigal-Perez LA. Resveratrol cytotoxicity is energy-dependent. J Food Biochem. 2019;43(9):e13008.
Ho Y, Sh Yang YC, Chin YT, Chou SY, Chen YR, Shih YJ, et al. Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R. Food Chem Toxicol. 2018;120:346-55.
Popescu M, Bogdan C, Pintea A, Rugină D, Ionescu C. Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy. Drug Des Devel Ther. 2018:1985-96.
Andrade S, Ramalho MJ, Pereira MDC, Loureiro JA. Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment. Front Pharmacol. 2018;9:1261.
Zhao H, Chen S, Gao K, Zhou Z, Wang C, Shen Z, et al. Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway. Neuroscience. 2017;348:241-51.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43.
Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P, Knottnerus A. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2011;64(4):380-2.
Zhang L, Wang H, Zhou X, Mao L, Ding K, Hu Z. Role of mitochondrial calcium uniporter‐mediated Ca2+ and iron accumulation in traumatic brain injury. J Cell Mol Med. 2019;23(4):2995-3009.
Liu Z, Yao X, Jiang W, Li W, Zhu S, Liao C, et al. Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury. J Neuroinflammation. 2020;17:1-21.
Ge MH, Tian H, Mao L, Li DY, Lin JQ, Hu HS, et al. Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway. CNS Neurosci Ther. 2021;27(9):1023-40.
Ge Mh, Tian H, Mao L, Li Dy, Lin Jq, Hu Hs, et al. Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway. CNS Neuroscience & Therapeutics. 2021;27(9):1023-40.
Lin X, Zhu J, Ni H, Rui Q, Sha W, Yang H, et al. Treatment With 2-BFI Attenuated Spinal Cord Injury by Inhibiting Oxidative Stress and Neuronal Apoptosis via the Nrf2 Signaling Pathway. Front Cell Neurosci. 2019;13:567.
- Abstract Viewed: 123 times
- PDF Downloaded: 97 times
