SARS-CoV-2 Antigen Rapid Test in the Emergency Department; a Diagnostic Accuracy Study
Journal of Practical Emergency Medicine,
Vol. 10 No. 1 (2023),
1 Dey 2023
,
Page e1
https://doi.org/10.22037/jpem.v10i1.39247
Abstract
Background: Rapid antigen tests have gained importance during the COVID-19 pandemic due to low prices and availability. The present study investigated the performance of the SARS-CoV-2 rapid diagnostic test in diagnosing patients with COVID-19 referred to the emergency department.
Methods: In this diagnostic accuracy study, patients with suspected COVID-19 referred to Imam Hossein and Shohadaye Tajrish Hospitals, Tehran, Iran, were examined. All patients were subjected to a rapid corona test according to the manufacturer’s guide and a chest computed tomography (CT) scan as the standard test. The screening characteristics of the rapid test compared to CT scan were calculated and reported.
Results: 183 people with an average age of 46.83 ± 14.26 (range: 21-83) years entered the study. 141 suspected cases of COVID-19 (77%) had evidence of lung involvement in CT, and the rapid test was positive in 83 (45%) cases. Out of 83 patients who tested positive for COVID-19, all (100%) had positive chest CT findings. Out of the 100 patients who tested negative, 42 patients (42%) had negative chest CT findings, and 58 patients (58%) had positive CT scans. The sensitivity, specificity, and accuracy of the mentioned test were 58.86, 100.00, and 68.30 percent, respectively.
Conclusion: Due to the relatively low sensitivity, the Rapid SARS-CoV-2 antigen test fails to screen for SARS-CoV-2 infection. However, it can be used to confirm the presence of the disease in symptomatic individuals and reduce virus transmission during the COVID-19 pandemic.
- COVID-19
- SARS-CoV-2
- Rapid test
- Diagnostic testing
- Diagnosis
- Antigen test
How to Cite
References
Yüce, M., E. Filiztekin, and K.G. Özkaya, COVID-19 diagnosis -A review of current methods. Biosens Bioelectron, 2021. 172: p. 112752.
Rai, P., et al., Detection technologies and recent developments in the diagnosis of COVID-19 infection. Appl Microbiol Biotechnol, 2021. 105(2): p. 441-455.
Bhusal, L., et al., Virology, Clinical Features and Diagnosis of COVID 19: Review Analysis. Kathmandu Univ Med J (KUMJ), 2020. 18(70): p. 75-79.
Moshref, M., et al., A Review on Rapid Detection Methods of COVID-19. Journal of Marine Medicine, 2021. 3(4): p. 96-110.
Lisboa Bastos, M., et al., Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis. BMJ, 2020. 370: p. m2516.
Hoffman, T., et al., Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2. Infect Ecol Epidemiol, 2020. 10(1): p. 1754538.
Ravi, N., et al., Diagnostics for SARS-CoV-2 detection: A comprehensive review of the FDA-EUA COVID-19 testing landscape. Biosens Bioelectron, 2020. 165: p. 112454.
Falzone, L., et al., Current and innovative methods for the diagnosis of COVID‑19 infection (Review). Int J Mol Med, 2021. 47(6).
Cheng, C.C., et al., Evaluation of a Rapid Antigen Test for the Diagnosis of SARS-CoV-2 during the COVID-19 Pandemic. Inquiry, 2022. 59: p. 469580221105354.
Scohy, A., et al., Low performance of rapid antigen detection test as frontline testing for COVID-19 diagnosis. J Clin Virol, 2020. 129: p. 104455.
Winkel, B., et al., Screening for SARS-CoV-2 infection in asymptomatic individuals using the Panbio COVID-19 antigen rapid test (Abbott) compared with RT-PCR: a prospective cohort study. BMJ Open, 2021. 11(10): p. e048206.
Diez Flecha, C., et al., [Internal validity of a rapid test for COVID-19 antigens in a nursing home]. Semergen, 2021. 47(5): p. 332-336.
Yamayoshi, S., et al., Comparison of Rapid Antigen Tests for COVID-19. Viruses, 2020. 12(12).
Möckel, M., et al., SARS-CoV-2 antigen rapid immunoassay for diagnosis of COVID-19 in the emergency department. Biomarkers, 2021. 26(3): p. 213-220.
Favresse, J., et al., Head-to-Head Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 Infection. J Clin Med, 2021. 10(2).
Mak, G.C., et al., Evaluation of rapid antigen test for detection of SARS-CoV-2 virus. J Clin Virol, 2020. 129: p. 104500.
Soleimani, R., et al., Rapid COVID-19 antigenic tests: Usefulness of a modified method for diagnosis. J Med Virol, 2021. 93(9): p. 5655-5659.
Linares, M., et al., Panbio antigen rapid test is reliable to diagnose SARS-CoV-2 infection in the first 7 days after the onset of symptoms. J Clin Virol, 2020. 133: p. 104659.
Peeling, R.W., et al., Scaling up COVID-19 rapid antigen tests: promises and challenges. Lancet Infect Dis, 2021. 21(9): p. e290-e295.
Chaimayo, C., et al., Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand. Virol J, 2020. 17(1): p. 177.
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