Journal of Lasers in Medical Sciences <p>The <strong><span style="color: #c21807;">Journal of Lasers in Medical Sciences ( JLMS) </span></strong>is a scientific <strong><span style="color: #c21807;">Continuously</span></strong><strong>*</strong> publication of the <strong><a href="">Laser Application in Medical Sciences Research Center</a>,&nbsp;</strong><a href="" target="_blank" rel="noopener"><strong>Shahid Beheshti University of Medical Sciences</strong>.</a> This journal accepts original papers, review articles, case reports, brief reports, case series, photo essays, letters to the editor, and commentaries in the field of<strong> Laser</strong> or <strong>Light</strong> in any field of medicine such as the following medical specialties: Dermatology, General and Vascular Surgery, Oncology, Cardiology, Dentistry, Urology, Rehabilitation, Ophthalmology, Otorhinolaryngology, Gynecology &amp; Obstetrics, Internal Medicine, Orthopedics, Neurosurgery, Radiology, Pain Medicine (Algology). Journal of Lasers in Medical Sciences has received a scientific and research score from the National Medical Publication Committee.</p> <p><strong>*JLMS</strong> was the quarterly publication from 2010 to 2020. We changed the type of publication to <strong><span style="color: #c21807;">Continuously</span></strong>&nbsp;from 2021 and publish a volume continuously (one volume) each year. Also, the print publication type publishes at the end of each year.</p> <p>&nbsp;</p> Shahid Beheshti University of Medical Sciences en-US Journal of Lasers in Medical Sciences 2008-9783 <p>Authors who publish with this journal agree to the following terms:</p> <p><strong>Copyright Rules</strong></p> <p>Upon publication, each author agrees that the “Laser application in Medical Sciences Research Center” is the copyright owner of the material published in “Journal of Lasers in Medical Sciences”. The users are free to copy, distribute, and display the work; to make any reasonable noncommercial use of the work, subject to proper attribution of authorship and ownership of the rights. Authors may use their material in presentations and subsequent publications they write or edit themselves, provided that “Journal of Lasers in Medical Sciences” is notified in writing and is acknowledged as the original publication.</p> <p><strong>Post-publication discussions and corrections:</strong></p> <p>The journal reserves the right to publish corrections to the former version of the manuscript, revise it, or retract the article even after publication. Post-publication discussion may be executed through Letter to Editor.</p> <p><strong>&nbsp;</strong>Retraction Policy</p> <p>Our journal takes measures in accordance to <a href="" target="_blank" rel="noopener"><strong><u>COPE flowcharts</u></strong></a> in case of encountering an article that needs to be retracted.&nbsp;</p> Experimental Analysis of Vaginal Laxity in Rats Treated With a Combination of Er:YAG Fractional Lasers and AMSC-MP <p><strong>Introduction:</strong> Vaginal laxity, a symptom of pelvic floor dysfunction observed in women, has many negative biological and psychological impacts. Laser treatments and stem cell-based therapies are emerging therapeutic methods for treating this condition. This study aimed to determine changes in vaginal laxity in model rats using a combination therapy of erbium-doped yttrium aluminium garnet (Er:YAG) fractional lasers and topical treatment with amniotic membrane stem cell metabolite products (AMSC-MP).<br><strong>Methods:</strong> The experimental animal population comprised 36 female white rats (Rattus norvegicus; 2-day-post-vaginal-delivery rats) allocated into the following four groups (n=9): K1, untreated two-day-post-vaginal-delivery rats; K2, two-day-post-vaginal-delivery rats treated with topical gel without AMSC-MP; P1, two-day-post-vaginal-delivery rats treated with Er: YAG fractional lasers and topical gel without AMSC-MP; P2, two-day-post-vaginal-delivery rats treated with Er: YAG fractional lasers and topical gel containing AMSC-MP. Immunohistochemical (IHC) examination was carried out for the expression and activity of heat shock protein 70 (HSP-70), collagen-1, tissue inhibitors of metalloproteinase 1 (TIMP-1), and matrix metalloproteinase 1 (MMP-1), as well as vaginal mucosal thickness.<br><strong>Results:</strong> There was a significant difference (P&lt;0.05) in the expression of HSP-70 among all groups except K2 and P1 (P&gt;0.05); there was no significant difference in type I collagen and TIMP-1 expression between the groups (P&gt;0.05); there was a significant difference (P&lt;0.05) in MMP-1 activity, with the activity in the K2 group (5.79±0.83) being higher than that in the P1 group (4.44±1.82) and that in the K1 group (5.74±1.03) being higher than that in the P2 group (4.24±1.55). Also, there was a significant difference in the thickness of the vaginal mucosa in all groups except K2 and P1 (P&gt;0.05).<br><strong>Conclusion:</strong> Er:YAG fractional laser and AMSC-MP combination therapy improved vaginal laxity in model rats by increasing Hsp70 expression and vaginal mucosal thickness and decreasing MMP-1 activity.</p> Trisniartami Setyaningrum Muhammad Yulianto Listiawan Listiawan Budi Santoso Cita Rosita Sigid Prakoeswa Widjiati Widjiati Brahmana Askandar Tjokroprawiro Copyright (c) 2023 Journal of Lasers in Medical Sciences 2023-01-30 2023-01-30 14 e2 e2 Photobiomodulation Therapy as an Adjuvant Treatment of Cervicofacial Liposuction Complications <p><strong>Introduction:</strong> Cervical suction lipectomy (CSL) procedures result in practically inevitable complications after the operation, such as facial edema and bruise. Photobiomodulation therapy (PBMT) can be used for analgesia, modulation of inflammatory processes, and improved tissue healing.<br><strong>Case Report:</strong> We have reported two cases of patients in which this therapy was used to manage complications related CSL. As they had already been medicated and still had these side effects, the PBMT was proposed for local analgesia, nerve repair, and modulation of the inflammatory process. Within 72 hours after a single PBMT session, there was an important reduction in the severity of all situations.<br><strong>Conclusion:</strong> PBMT seems safe and effective in managing pain and edema-related CSL.</p> Leticia Boaro Angelica Pimentel Daniela Muknicka Sumaya Bordalo Luana Campos Copyright (c) 2023 Journal of Lasers in Medical Sciences 2023-01-29 2023-01-29 14 e1 e1