Autophagy Role as a Double-Edged Sword in Anesthesiology and Critical Care
Journal of Cellular & Molecular Anesthesia,
Vol. 6 No. 1 (2021),
17 March 2021
,
Page 39-49
https://doi.org/10.22037/jcma.v6i1.32381
Abstract
Autophagy is a mechanism, which host cells can utilize it to defend against infections. Trapped cargo such as viral cargo and delivered to a lysosome for degradation. Primary immune response against some viruses can start by autophagy mechanism. In this study, we reviewed role of autophagy in viral infections.
Keywords:
- Autophagy, Viral infection, Macroautophagy
How to Cite
1.
Zandi M, Fazeli M, Ghadimi P, Soltani S, Jalilian FA, Banai Shahani A, Behboudi E, Pourhossein B. Autophagy Role as a Double-Edged Sword in Anesthesiology and Critical Care. J Cell Mol Anesth [Internet]. 2021 Jan. 25 [cited 2024 Apr. 19];6(1):39-4. Available from: https://journals.sbmu.ac.ir/jcma/article/view/32381
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17. Tian Y, Wang M-L, Zhao J. Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity. 2019;11(2):132.
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37. Waisner H, Kalamvoki M. The ICP0 Protein of Herpes Simplex Virus 1 (HSV-1) Downregulates Major Autophagy Adaptor Proteins Sequestosome 1 and Optineurin during the Early Stages of HSV-1 Infection. 2019;93(21):e01258-19.
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41. Yeganeh B, Ghavami S, Rahim MN, Klonisch T, Halayko A, Coombs K. Autophagy activation is required for influenza A virus-induced apoptosis and replication. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2018;1865(2):364-78.
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43. Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13(4):739-53.
44. Peng J, Zhu S, Hu L, Ye P, Wang Y, Tian Q, et al. Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines. Autophagy. 2016;12(10):1704-20.
45. Li L, Jin H, Wang H, Cao Z, Feng N, Wang J, et al. Autophagy is highly targeted among host comparative proteomes during infection with different virulent RABV strains. Oncotarget. 2017;8(13):21336-50.
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1. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132(1):27-42.
2. Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation. Antioxidants & redox signaling. 2014;20(3):460-73.
3. Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nature cell biology. 2010;12(9):814-22.
4. Klionsky DJ. Autophagy revisited: a conversation with Christian de Duve. Autophagy. 2008;4(6):740-3.
5. Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221(1):3-12.
6. Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011;469(7330):323-35.
7. Levine B. Eating Oneself and Uninvited Guests: Autophagy-Related Pathways in Cellular Defense. Cell. 2005;120(2):159-62.
8. Tian Y, Wang M-L, Zhao J. Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity. 2019;11(2):132.
9. Morris DH, Yip CK, Shi Y, Chait BT, Wang QJ. Beclin 1-Vps34 complex architecture: understanding the nuts and bolts of therapeutic targets. Frontiers in biology. 2015;10(5):398-426.
10. Gannagé M, Münz C. Macroautophagy in immunity and tolerance. Traffic. 2009;10(6):615-20.
11. He L, Eslamfam S, Ma X, Li D. Autophagy and the nutritional signaling pathway. Front Agric Sci Eng. 2016;3:222-30.
12. Cuervo A, Dice J. Regulation of lamp2a levels in the lysosomal membrane. Traffic. 2000;1(7):570-83.
13. Kettern N, Dreiseidler M, Tawo R, Höhfeld J. Chaperone-assisted degradation: multiple paths to destruction. Biological chemistry. 2010;391(5):481-9.
14. Li W-w, Li J, Bao J-k. Microautophagy: lesser-known self-eating. Cellular and molecular life sciences. 2012;69(7):1125-36.
15. Voigt O, Pöggeler S. Self-eating to grow and kill: autophagy in filamentous ascomycetes. Applied microbiology and biotechnology. 2013;97(21):9277-90.
16. Kudchodkar SB, Levine B. Viruses and autophagy. Reviews in medical virology. 2009;19(6):359-78.
17. Chiramel AI, Brady NR, Bartenschlager R. Divergent roles of autophagy in virus infection. Cells. 2013;2(1):83-104.
18. Ahmad L, Mostowy S, Sancho-Shimizu V. Autophagy-Virus Interplay: From Cell Biology to Human Disease. 2018;6(155).
19. Wang Y, Jiang K, Zhang Q, Meng S, Ding C. Autophagy in Negative-Strand RNA Virus Infection. 2018;9(206).
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21. Zhou D, Spector SA. Human immunodeficiency virus type-1 infection inhibits autophagy. AIDS (London, England). 2008;22(6):695.
22. Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nature Reviews Immunology. 2013;13(10):722-37.
23. Choi Y, Bowman JW, Jung JU. Autophagy during viral infection—a double-edged sword. Nature Reviews Microbiology. 2018;16(6):341-54.
24. Guo F, Liu X, Cai H, Le W. Autophagy in neurodegenerative diseases: pathogenesis and therapy. Brain pathology. 2018;28(1):3-13.
25. Ahr B, Robert-Hebmann V, Devaux C, Biard-Piechaczyk M. Apoptosis of uninfected cells induced by HIV envelope glycoproteins. Retrovirology. 2004;1(1):1-12.
26. Liu Z, Xiao Y, Torresilla C, Rassart É, Barbeau B. Implication of different HIV-1 genes in the modulation of autophagy. Viruses. 2017;9(12):389.
27. Akbay B, Shmakova A, Vassetzky Y, Dokudovskaya S. Modulation of mTORC1 Signaling Pathway by HIV-1. Cells. 2020;9(5):1090.
28. Sagnier S, Daussy CF, Borel S, Robert-Hebmann V, Faure M, Blanchet FP, et al. Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes. Journal of virology. 2015;89(1):615-25.
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30. McFarlane S, Aitken J, Sutherland JS, Nicholl MJ, Preston VG, Preston CM. Early Induction of Autophagy in Human Fibroblasts after Infection with Human Cytomegalovirus or Herpes Simplex Virus 1. 2011;85(9):4212-21.
31. Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, et al. STING directly activates autophagy to tune the innate immune response. Cell Death & Differentiation. 2019;26(9):1735-49.
32. Orvedahl A, Levine B. Autophagy and viral neurovirulence. 2008;10(9):1747-56.
33. Orvedahl A, Alexander D, Talloczy Z, Sun Q, Wei Y, Zhang W, et al. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe. 2007;1(1):23-35.
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35. Lussignol M, Queval C, Bernet-Camard M-F, Cotte-Laffitte J, Beau I, Codogno P, et al. The Herpes Simplex Virus 1 Us11 Protein Inhibits Autophagy through Its Interaction with the Protein Kinase PKR. 2013;87(2):859-71.
36. Mulvey M, Camarena V, Mohr I. Full Resistance of Herpes Simplex Virus Type 1-Infected Primary Human Cells to Alpha Interferon Requires both the Us11 and γ134.5 Gene Products. 2004;78(18):10193-6.
37. Waisner H, Kalamvoki M. The ICP0 Protein of Herpes Simplex Virus 1 (HSV-1) Downregulates Major Autophagy Adaptor Proteins Sequestosome 1 and Optineurin during the Early Stages of HSV-1 Infection. 2019;93(21):e01258-19.
38. Mulvey M, Arias C, Mohr I. Maintenance of Endoplasmic Reticulum (ER) Homeostasis in Herpes Simplex Virus Type 1-Infected Cells through the Association of a Viral Glycoprotein with PERK, a Cellular ER Stress Sensor. 2007;81(7):3377-90.
39. Ochiai H, Sakai S, Hirabayashi T, Shimizu Y, Terasawa K. Inhibitory effect of bafilomycin A1, a specific inhibitor of vacuolar-type proton pump, on the growth of influenza A and B viruses in MDCK cells. Antiviral research. 1995;27(4):425-30.
40. Ahmad L, Mostowy S, Sancho-Shimizu V. Autophagy-virus interplay: from cell biology to human disease. Frontiers in cell and developmental biology. 2018;6:155.
41. Yeganeh B, Ghavami S, Rahim MN, Klonisch T, Halayko A, Coombs K. Autophagy activation is required for influenza A virus-induced apoptosis and replication. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2018;1865(2):364-78.
42. Wang Z, Miao G, Xue X, Guo X, Yuan C, Wang Z, et al. The Vici syndrome protein EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. Molecular cell. 2016;63(5):781-95.
43. Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13(4):739-53.
44. Peng J, Zhu S, Hu L, Ye P, Wang Y, Tian Q, et al. Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines. Autophagy. 2016;12(10):1704-20.
45. Li L, Jin H, Wang H, Cao Z, Feng N, Wang J, et al. Autophagy is highly targeted among host comparative proteomes during infection with different virulent RABV strains. Oncotarget. 2017;8(13):21336-50.
46. Liu J, Liao M, Yan Y, Yang H, Wang H, Zhou J. Rabies virus phosphoprotein P5 binding to BECN1 regulates self-replication by BECN1-mediated autophagy signaling pathway. Research Square; 2020.
47. Ge J, Wang X, Tao L, Wen Z, Feng N, Yang S, et al. Newcastle Disease Virus-Vectored Rabies Vaccine Is Safe, Highly Immunogenic, and Provides Long-Lasting Protection in Dogs and Cats. 2011;85(16):8241-52.
48. García-Valtanen P, Ortega-Villaizán MdM, Martínez-López A, Medina-Gali R, Pérez L, Mackenzie S, et al. Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. Autophagy. 2014;10(9):1666-80.
49. He Y, Staschke KA, Tan S-L. HCV NS5A: a multifunctional regulator of cellular pathways and virus replication. Hepatitis C viruses: genomes and molecular biology: Horizon Bioscience; 2006.
50. Dreux M, Chisari FV. Impact of the autophagy machinery on hepatitis C virus infection. Viruses. 2011;3(8):1342-57.
51. Hetz C, Papa FR. The unfolded protein response and cell fate control. Molecular cell. 2018;69(2):169-81.
52. Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxidants & redox signaling. 2014;21(3):396-413.
53. Jin SM, Youle RJ. PINK1-and Parkin-mediated mitophagy at a glance. Journal of cell science. 2012;125(4):795-9.
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61. Crawford SE, Estes MK. Viroporin-mediated calcium-activated autophagy. Autophagy. 2013;9(5):797-8.
62. Crawford SE, Criglar JM, Liu Z, Broughman JR, Estes MK. COPII Vesicle Transport Is Required for Rotavirus NSP4 Interaction with the Autophagy Protein LC3 II and Trafficking to Viroplasms. Journal of virology. 2019;94(1):e01341-19.
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2. Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation. Antioxidants & redox signaling. 2014;20(3):460-73.
3. Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nature cell biology. 2010;12(9):814-22.
4. Klionsky DJ. Autophagy revisited: a conversation with Christian de Duve. Autophagy. 2008;4(6):740-3.
5. Morris DH, Yip CK, Shi Y, Chait BT, Wang QJ. Beclin 1-Vps34 complex architecture: understanding the nuts and bolts of therapeutic targets. Frontiers in biology. 2015;10(5):398-426.
6. Gannagé M, Münz C. Macroautophagy in immunity and tolerance. Traffic. 2009;10(6):615-20.
7. He L, Eslamfam S, Ma X, Li D. Autophagy and the nutritional signaling pathway. Front Agric Sci Eng. 2016;3:222-30.
8. Cuervo A, Dice J. Regulation of lamp2a levels in the lysosomal membrane. Traffic. 2000;1(7):570-83.
9. Kettern N, Dreiseidler M, Tawo R, Höhfeld J. Chaperone-assisted degradation: multiple paths to destruction. Biological chemistry. 2010;391(5):481-9.
10. Li W-w, Li J, Bao J-k. Microautophagy: lesser-known self-eating. Cellular and molecular life sciences. 2012;69(7):1125-36.
11. Voigt O, Pöggeler S. Self-eating to grow and kill: autophagy in filamentous ascomycetes. Applied microbiology and biotechnology. 2013;97(21):9277-90.
12. Kudchodkar SB, Levine B. Viruses and autophagy. Reviews in medical virology. 2009;19(6):359-78.
13. Chiramel AI, Brady NR, Bartenschlager R. Divergent roles of autophagy in virus infection. Cells. 2013;2(1):83-104.
14. Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221(1):3-12.
15. Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011;469(7330):323-35.
16. Levine B. Eating Oneself and Uninvited Guests: Autophagy-Related Pathways in Cellular Defense. Cell. 2005;120(2):159-62.
17. Tian Y, Wang M-L, Zhao J. Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity. 2019;11(2):132.
18. Ahmad L, Mostowy S, Sancho-Shimizu V. Autophagy-Virus Interplay: From Cell Biology to Human Disease. 2018;6(155).
19. Wang Y, Jiang K, Zhang Q, Meng S, Ding C. Autophagy in Negative-Strand RNA Virus Infection. 2018;9(206).
20. Rosenberg ES, Altfeld M, Poon SH, Phillips MN, Wilkes BM, Eldridge RL, et al. Immune control of HIV-1 after early treatment of acute infection. Nature. 2000;407(6803):523-6.
21. Zhou D, Spector SA. Human immunodeficiency virus type-1 infection inhibits autophagy. AIDS (London, England). 2008;22(6):695.
22. Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nature Reviews Immunology. 2013;13(10):722-37.
23. Choi Y, Bowman JW, Jung JU. Autophagy during viral infection—a double-edged sword. Nature Reviews Microbiology. 2018;16(6):341-54.
24. Guo F, Liu X, Cai H, Le W. Autophagy in neurodegenerative diseases: pathogenesis and therapy. Brain pathology. 2018;28(1):3-13.
25. Ahr B, Robert-Hebmann V, Devaux C, Biard-Piechaczyk M. Apoptosis of uninfected cells induced by HIV envelope glycoproteins. Retrovirology. 2004;1(1):1-12.
26. Liu Z, Xiao Y, Torresilla C, Rassart É, Barbeau B. Implication of different HIV-1 genes in the modulation of autophagy. Viruses. 2017;9(12):389.
27. Akbay B, Shmakova A, Vassetzky Y, Dokudovskaya S. Modulation of mTORC1 Signaling Pathway by HIV-1. Cells. 2020;9(5):1090.
28. Sagnier S, Daussy CF, Borel S, Robert-Hebmann V, Faure M, Blanchet FP, et al. Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes. Journal of virology. 2015;89(1):615-25.
29. Rasmussen SB, Horan KA, Holm CK, Stranks AJ, Mettenleiter TC, Simon AK, et al. Activation of Autophagy by α-Herpesviruses in Myeloid Cells Is Mediated by Cytoplasmic Viral DNA through a Mechanism Dependent on Stimulator of IFN Genes. 2011;187(10):5268-76.
30. McFarlane S, Aitken J, Sutherland JS, Nicholl MJ, Preston VG, Preston CM. Early Induction of Autophagy in Human Fibroblasts after Infection with Human Cytomegalovirus or Herpes Simplex Virus 1. 2011;85(9):4212-21.
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34. JOANY CHOU J-JC, MARTIN GROSSt, BERNARD ROIZMAN. Association of a Mr 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2a and premature shutoff of protein synthesis after infection with y134.5- mutants of herpes simplex virus 1. 1995.
35. Lussignol M, Queval C, Bernet-Camard M-F, Cotte-Laffitte J, Beau I, Codogno P, et al. The Herpes Simplex Virus 1 Us11 Protein Inhibits Autophagy through Its Interaction with the Protein Kinase PKR. 2013;87(2):859-71.
36. Mulvey M, Camarena V, Mohr I. Full Resistance of Herpes Simplex Virus Type 1-Infected Primary Human Cells to Alpha Interferon Requires both the Us11 and γ134.5 Gene Products. 2004;78(18):10193-6.
37. Waisner H, Kalamvoki M. The ICP0 Protein of Herpes Simplex Virus 1 (HSV-1) Downregulates Major Autophagy Adaptor Proteins Sequestosome 1 and Optineurin during the Early Stages of HSV-1 Infection. 2019;93(21):e01258-19.
38. Mulvey M, Arias C, Mohr I. Maintenance of Endoplasmic Reticulum (ER) Homeostasis in Herpes Simplex Virus Type 1-Infected Cells through the Association of a Viral Glycoprotein with PERK, a Cellular ER Stress Sensor. 2007;81(7):3377-90.
39. Ochiai H, Sakai S, Hirabayashi T, Shimizu Y, Terasawa K. Inhibitory effect of bafilomycin A1, a specific inhibitor of vacuolar-type proton pump, on the growth of influenza A and B viruses in MDCK cells. Antiviral research. 1995;27(4):425-30.
40. Ahmad L, Mostowy S, Sancho-Shimizu V. Autophagy-virus interplay: from cell biology to human disease. Frontiers in cell and developmental biology. 2018;6:155.
41. Yeganeh B, Ghavami S, Rahim MN, Klonisch T, Halayko A, Coombs K. Autophagy activation is required for influenza A virus-induced apoptosis and replication. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2018;1865(2):364-78.
42. Wang Z, Miao G, Xue X, Guo X, Yuan C, Wang Z, et al. The Vici syndrome protein EPG5 is a Rab7 effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes. Molecular cell. 2016;63(5):781-95.
43. Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13(4):739-53.
44. Peng J, Zhu S, Hu L, Ye P, Wang Y, Tian Q, et al. Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines. Autophagy. 2016;12(10):1704-20.
45. Li L, Jin H, Wang H, Cao Z, Feng N, Wang J, et al. Autophagy is highly targeted among host comparative proteomes during infection with different virulent RABV strains. Oncotarget. 2017;8(13):21336-50.
46. Liu J, Liao M, Yan Y, Yang H, Wang H, Zhou J. Rabies virus phosphoprotein P5 binding to BECN1 regulates self-replication by BECN1-mediated autophagy signaling pathway. Research Square; 2020.
47. Ge J, Wang X, Tao L, Wen Z, Feng N, Yang S, et al. Newcastle Disease Virus-Vectored Rabies Vaccine Is Safe, Highly Immunogenic, and Provides Long-Lasting Protection in Dogs and Cats. 2011;85(16):8241-52.
48. García-Valtanen P, Ortega-Villaizán MdM, Martínez-López A, Medina-Gali R, Pérez L, Mackenzie S, et al. Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. Autophagy. 2014;10(9):1666-80.
49. He Y, Staschke KA, Tan S-L. HCV NS5A: a multifunctional regulator of cellular pathways and virus replication. Hepatitis C viruses: genomes and molecular biology: Horizon Bioscience; 2006.
50. Dreux M, Chisari FV. Impact of the autophagy machinery on hepatitis C virus infection. Viruses. 2011;3(8):1342-57.
51. Hetz C, Papa FR. The unfolded protein response and cell fate control. Molecular cell. 2018;69(2):169-81.
52. Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxidants & redox signaling. 2014;21(3):396-413.
53. Jin SM, Youle RJ. PINK1-and Parkin-mediated mitophagy at a glance. Journal of cell science. 2012;125(4):795-9.
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