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  3. Vol. 6 No. 2 (2021): April 2021
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ISSN: 2538-2462

April 2021
Vol. 6 No. 2 (2021)

Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial

  • Mahboubeh Darban
  • Farhad Malek
  • Mohammad Memarian
  • Ali Gohari
  • Arda Kiani
  • Alireza Emadi
  • Samaneh Lavvaf
  • Bahador Bagheri

Journal of Cellular & Molecular Anesthesia, Vol. 6 No. 2 (2021), , Page 164-167
https://doi.org/10.22037/jcma.v6i2.32182 Published 15 December 2020

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Abstract

INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19.


METHODS:  Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers.


RESULTS: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between 2 groups (P > 0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although not significant. No significant difference was noted in length of ICU stay between 2 groups (P = 0.3).


CONCLUSION: Our study suggests that addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19. 

Keywords:
  • Covid-19, Vitamin C, Melatonin, ICU, Hypoxemia
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How to Cite

1.
Darban M, Malek F, Memarian M, Gohari A, Kiani A, Emadi A, Lavvaf S, Bagheri B. Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial. J Cell Mol Anesth [Internet]. 2020Dec.15 [cited 2023Feb.6];6(2):164-7. Available from: https://journals.sbmu.ac.ir/jcma/article/view/32182
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References

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