Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial
Journal of Cellular & Molecular Anesthesia,
Vol. 6 No. 2 (2021),
2 Tir 2021
,
Page 164-167
https://doi.org/10.22037/jcma.v6i2.32182
Abstract
INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19.
METHODS: Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers.
RESULTS: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between 2 groups (P > 0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although not significant. No significant difference was noted in length of ICU stay between 2 groups (P = 0.3).
CONCLUSION: Our study suggests that addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19.
- Covid-19, Vitamin C, Melatonin, ICU, Hypoxemia
How to Cite
References
Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020;395(10223):470-3.
Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020;382(10):929-36.
Ziaie S, Koucheck M, Miri M, Salarian S, Shojaei S, Haghighi M, et al. Review of Therapeutic Agents for Treatment of COVID-19. J Cell Mol Anesth. 2020;5(1):32-6.
Rajaei S, Dabbagh A. The immunologic basis of COVID-19: a clinical approach. J Cell Mol Anesth. 2020;5(1):37-42.
Wongchitrat P, Shukla M, Sharma R, Govitrapong P, Reiter RJ. Role of Melatonin on Virus-Induced Neuropathogenesis-A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection. Antioxidants (Basel). 2021;10(1).
Rodic S, McCudden C, van Walraven C. The Prognostic Value of Serum Zinc Levels in Acutely Hospitalized Patients: a Systematic Review. Biol Trace Elem Res. 2021.
Kuhn SO, Meissner K, Mayes LM, Bartels K. Vitamin C in sepsis. Curr Opin Anaesthesiol. 2018;31(1):55-60.
JamaliMoghadamSiahkali S, Zarezade B, Koolaji S, SeyedAlinaghi S, Zendehdel A, Tabarestani M, et al. Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial. Eur J Med Res. 2021;26(1):20.
Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care. 2021;11(1):5.
Thomas S, Patel D, Bittel B, Wolski K, Wang Q, Kumar A, et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2021;4(2):e210369.
Nooraee N, Fathi M, Edalat L, Behnaz F, Mohajerani SA, Dabbagh A. Effect of Vitamin C on Serum Cortisol after Etomidate Induction of Anesthesia. J Cell Mol Anesth. 2016;1(1):28-33.
- Abstract Viewed: 3078 times
- PDF Downloaded: 693 times