The effect of 1,25 (OH)2 Vitamin D3 on serum levels of inflammatory cytokines in patients undergoing CABG
Journal of Cellular & Molecular Anesthesia,
Vol. 3 No. 3 (2018),
4 November 2018
,
Page 98-102
https://doi.org/10.22037/jcma.v3i3.19258
Abstract
Introduction: a number of preventive or therapeutic strategies have been proposed to compensate for the inflammatory process during adult cardiac surgeries; none have been considered definitive. 1,25 (OH)2 Vitamin D3 is among the so called physiologic hormones with immunomodulatory effects. This study assessed the effect of oral Vitamin D on serum levels of IL-1, IL-6 and TNF-α in adult CABG.
Materials and methods: in a double blind placebo controlled clinical trial, 80 patients entered the study after qualifying study criteria; being divided to Vitamin D and placebo groups, serum cytokines (IL-1, IL-6, and TNF-α) were measured preoperatively and also during the 1st day after the operation.
Results: serum TNF-α levels were similar in the 2 groups; however, postoperative levels of IL-1 and IL-6 were significantly lower in Vitamin D group.
Conclusion: the current study demonstrated that oral Vitamin D supplements could augment immunomodulatory effects in adult patients undergoing cardiac surgical procedures (mainly CABG).
Keywords: Vitamin D, Cardiopulmonary Bypass, Cytokine, Inflammation
- 1
- 25-Dihydroxyvitamin D3
- cytokine
- coronary artery bypass graft
- inflammation
How to Cite
References
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