Effect of Ketofol instead of Propofol on hemodynamic stabilization for induction of Anesthesia in Laparatomy
Journal of Cellular & Molecular Anesthesia,
Vol. 2 No. 2 (2017),
12 May 2017
,
Page 50-54
https://doi.org/10.22037/jcma.v2i2.14203
Abstract
Introduction: Hemodynamic alterations are a common complication during anesthetic induction with intravenous anesthesia. Hypotension due to propofol injection may be very severe in cardiac vascular patient. Ketamine produces the significant increasing but temporary in systematic blood stream, heartbeat, cardiac output through central sympathetic stimulation.
Objective: To determine effect of ketofol and propofol for induction of anesthesia on hemodynamic changes during induction of anesthesia
Methods: In a randomized cinical trial study 96 patient who were candidate for laparotomy enrolled and divided into two random group of propofol (48 person) and ketofol (48 person). Hemodynamic changes were recorded and examined after induction, after intubation and 5 and 10 minutes after intubation.
Results: Heart rate was significantly variable in propofol group compare to ketofol group. Systolic, Diastolic, and mean arterial blood pressure was not significantly changed during time period of recording in ketofol group. However, blood pressure was significantly changed during the study in propofol group.
Conclusion: ketofol is a proper alternative to propofol to stabilize heart rate and blood pressure in laparatomy.
- Ketofol
- hemodynamic
- anesthesia
- laparatomy
How to Cite
References
Coulter FL, Hannam JA, Anderson BJ. Ketofol dosing simulations for procedural sedation. Pediatr Emerg Care. 2014 Sep;30(9):621-30.
Andolfatto G, Willman E. A prospective case series of single-syringe ketamine-propofol (Ketofol) for emergency department procedural sedation and analgesia in adults. Acad Emerg Med. 2011 Mar; 18(3):237-45.
Smischney NJ, Beach ML, Loftus RW, Dodds TM, Koff MD. Ketamine/propofol admixture (ketofol) is associated with improved hemodynamics as an induction agent: a randomized, controlled trial. J Trauma Acute Care Surg. 2012 Jul; 73(1):94-101.
Chan CM, Mitchell AL, Shorr AF. Etomidate is associated with mortality and adrenal insufficiency in sepsis: a meta-analysis. Crit Care Med. 2012 Nov; 40(11):2945-53
Willman EV, Andolfatto G. A prospective evaluation of "ketofol" (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department. Ann Emerg Med. 2007 Jan; 49(1):23-30.
Green SM, Andolfatto G, Krauss BS. Ketofol for procedural sedation revisited: pro and con. Ann Emerg Med. 2015 May;65(5):489-91.
Olson AN, Rao WR, Marienau ME, Smischney NJ. Period Prevalence of Ketamine-Propofol Admixture "Ketofol" in the Operating Room among Anesthesia Providers at an Academic Medical Center. Med Sci Monit. 2015 Jun 16;21:1737-44.
Jalili M, Bahreini M, Doosti-Irani A, Masoomi R, Arbab M, Mirfazaelian H. Ketamine-propofol combination (ketofol) vs propofol for procedural sedation and analgesia: systematic review and meta-analysis.Am J Emerg Med. 2015 Dec 29. pii: S0735-6757(15)01130-4.
Gallo de Moraes A, Racedo Africano CJ, Hoskote SS, Reddy DR, Tedja R, Thakur L, Pannu JK, Hassebroek EC, Smischney NJ. Ketamine and propofol combination ("ketofol") for endotracheal intubations in critically ill patients: a case series. Am J Case Rep. 2015 Feb 13;16:81-6.
Hosseinzadeh H, Eidy M, Golzari SE, Vasebi M.Hemodynamic Stability during Induction of Anesthesia in ElderlyPatients: Propofol + Ketamine versus Propofol + Etomidate. J Cardiovasc Thorac Res. 2013;5(2):51-4. doi: 10.5681/jcvtr.2013.011. Epub 2013 Jun 27.
Yousef GT, Elsayed KM.A clinical comparison of ketofol (ketamine and propofol admixture) versus propofol as an induction agent on quality of laryngeal mask airway insertion and hemodynamic stability in children. Anesth Essays Res. 2013 May-Aug;7(2):194-9.
Erdogan MA, Begec Z, Aydogan MS, Ozgul U, Yucel A, Colak C, Durmus M. Comparison of effects of propofol and ketamine-propofol mixture (ketofol) on laryngeal mask airway insertion conditions and hemodynamics in elderly patients: a randomized, prospective, double-blind trial. J Anesth. 2013 Feb;27(1):12-7. doi: 10.1007/s00540-012-1484-5.
Goh PK, Chiu CL, Wang CY, Chan YK, Loo PL.Randomized double-blind comparison of ketamine-propofol, fentanyl-propofol and propofol-saline on haemodynamics and laryngeal mask airway insertion conditions. Anaesth Intensive Care. 2005 Apr;33(2):223-8.
Miller RD, Eriksson LI, Fleisher L, Wiener-Kronish JP, Young WL. Millers anesthesia, 8 Ed. Philadelphia : Churchill Livingstone/Elsevier;2015
- Abstract Viewed: 740 times
- PDF Downloaded: 681 times