ISSN: 2538-2462
April 2016
Vol. 1 No. 2 (2016)
chronic sleep deprevation and ventricular arrhythmias: effect of symphatic nervous system
Journal of Cellular & Molecular Anesthesia,
Vol. 1 No. 2 (2016),
,
Page 56-61
https://doi.org/10.22037/jcma.v1i2.10859
Abstract
Introduction: We assessed the effect of chronic sleep deprivation on incidence of ischemia/reperfusion-induced ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation) and the role of the sympathetic nervous system in this respect.
Material and methods: Rats were randomly divided into four groups; 1) ischemia/reperfusion group (IR): 30 minutes ischemia followed by 60 minutes reperfusion was induced, 2) control group (CON): rats has been placed in large multiple platforms for 72h prior to ischemia and reperfusion, 3) Chronic sleep deprivation group( SD): 72h sleep deprivation was induced by using small multiple platform prior to ischemia and reperfusion, 4) Sympathectomy group (SYM): chemical sympathectomy was done 24h before to chronic sleep deprivation and then underwent ischemia and reperfusion. The heart isolated and perfused by langendorff apparatus. After thoracotomy and aorta cannulation, the hearts perfused in the langendorff apparatus using krebs-Henseleit buffer. Hearts were allowed to recovery for 15 min. After recovery period, 15 minutes was considered as baseline prior to 30 minutes ischemia followed by 60 minutes reperfusion.Tow thin stainless stell electrodes fixed on the ventricular apex and right atrium for recording the lead II of electrocardiogram (ECG).
Results: There were no significant differences between heart rates between groups, and ventricular tachycardia significantly increased in chronic sleep deprivation group As compared with IR group in ischemia period. Sympathectomy significantly reduced ventricular tachycardia incidence when compared with SD. There is no difference in incidence of ventricular tachycardia between control group and IR group. The incidence of ventricular fibrillation during early reperfusion was significantly augmented (P<0.05) in sleep deprivation group as compared with IR group and Sympathectomy significantly could reverse ventricular fibrillation incidence to IR group level as compared with SD group (P<0.05).
Conclusion: Induction of 72 h sleep deprivation prior to ischemia and reperfusion increased the probability of ventricular tachycardia and ventricular fibrillation occurrence during ischemia and reperfusion and chemical sympathectomy could eliminate this effect.
- chronic sleep deprivation
- ventricular arrhythmia
- sympathetic nervous system
How to Cite
References
Montano N. Acute and chronic effects of sleep deprivation on autonomic nervous system in humans. Autonomic Neuroscience. 2015;192:24.
Rod NH, Kumari M, Lange T, Kivimäki M, Shipley M, Ferrie J. The joint effect of sleep duration and disturbed sleep on cause-specific mortality: Results from the Whitehall II cohort study. PloS one. 2014;9(4):e91965.
Fang Z, Ren Y-P, Lu C-Y, Li Y, Xu Q, Peng L, et al. Effects of Sleep Deprivation on Action Potential and Transient Outward Potassium Current in Ventricular Myocytes in Rats. Medical science monitor: international medical journal of experimental and clinical research. 2015;21:542.
Dettoni JL, Consolim-Colombo FM, Drager LF, Rubira MC, de Souza SBPC, Irigoyen MC, et al. Cardiovascular effects of partial sleep deprivation in healthy volunteers. Journal of Applied Physiology. 2012;113(2):232-6.
Kishi T. Heart failure as an autonomic nervous system dysfunction. Journal of cardiology. 2012;59(2):117-22.
Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacological Reviews. 2007;59(4):418-58.
Nagai M, Hoshide S, Kario K. Sleep duration as a risk factor for cardiovascular disease-a review of the recent literature. Current cardiology reviews. 2010;6(1):54.
Shen MJ, Zipes DP. Role of the autonomic nervous system in modulating cardiac arrhythmias. Circulation research. 2014;114(6):1004-21.
Imani A, Faghihi M, Keshavarz M, Karimian SM, Niaraki SS. Effect of different doses of noradrenaline against ischemia-induced ventricular arrhythmias in rat heart in vivo. Indian pacing and electrophysiology journal. 2009;9(1):35.
Joukar S, Ghorbani-Shahrbabaki S, Hajali V, Sheibani V, Naghsh N. Susceptibility to life-threatening ventricular arrhythmias in an animal model of paradoxical sleep deprivation. Sleep medicine. 2013;14(12):1277-82.
Holmes AL, Burgess HJ, McCULLOCH K, Lamond N, Fletcher A, DORRIAN J, et al. Daytime cardiac autonomic activity during one week of continuous night shift. Journal of human ergology. 2001;30(1/2):223-8.
Kato M, Phillips BG, Sigurdsson G, Narkiewicz K, Pesek CA, Somers VK. Effects of sleep deprivation on neural circulatory control. Hypertension. 2000;35(5):1173-5.
Viola A. Profound impact of the sleep and circadian system on autonomic control of the heart. Autonomic Neuroscience. 2015;192:24.
Sgoifo A, Buwalda B, Roos M, Costoli T, Merati G, Meerlo P. Effects of sleep deprivation on cardiac autonomic and pituitary-adrenocortical stress reactivity in rats. Psychoneuroendocrinology. 2006;31(2):197-208.
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