Frequency of Multi-Organ Injury in Definitive Patients with Covid - 19 hospitalized in Teaching Hospitals of Shahid Beheshti University of Medical Sciences
Iranian Journal of Emergency Medicine,
Vol. 8 No. 1 (2021),
23 November 2020
,
Page e16
https://doi.org/10.22037/ijem.v8i1.34679
Abstract
Introduction: The growing prevalence of the new corona virus covid -19 has challenged the public health of the world and has led to a morbid fear of contracting it in different people. Damage to various organs of the body and organ damage due to infection with this virus have been reported in various studies. This study aimed to investigate the frequency of multi-organ injury in definitive patients with covid -19 hospitalized in teaching hospitals of Shahid Beheshti University of Medical Sciences.
Materials & Methods: A descriptive cross-sectional study on 600 patients with Covid-19 based on RT_PCR diagnostic test and findings of CT scan of lungs of patients referred to Shohada-e-Tajrish and Imam Hossein hospitals by Easy and accessible sample method. Data were collected by using a researcher-made checklist. To analyze the data, SPSS 26 software and descriptive-comparative statistical methods, Chi-square and independent T were used.
Results: The results showed that out of 600 patients participating in this study, 58.5% were male and 41.5% were female with a mean age of 60.26 ± 17.78 years. 24.2% of patients have multi-organ injury. There was no statistically significant relationship between gender and multi-organ injuries, while there was a statistically significant relationship between mean age, pathological findings of lung, intubation or non-intubation of patients and past medical history of patient with multi-organ injuries.
Conclusion: Multi-organ injuries are relatively common in patients with Covid-19 and are associated with age, past medical hisory, pathological findings in the lung and the degree of pulmonary involvement. Most organs involved in multi-organ injury include the lungs, liver, heart, kidneys and coagulation system.
- Covid-19
- organ injury
- hospitalized patients
- frequency
How to Cite
References
Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. nature. 2020;579(7798):270-3.
de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nature Reviews Microbiology. 2016;14(8):523.
Johnson ER, Matthay MA. Acute lung injury: epidemiology, pathogenesis, and treatment. Journal of aerosol medicine and pulmonary drug delivery. 2010;23(4):243-52.
Lai C-C, Shih T-P, Ko W-C, Tang H-J, Hsueh P-RJIjoaa. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. 2020;55(3):105924.
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. 2020.
Ganji A, Mosayebi G, Khaki M, Ghazavi AJJoAUoMS. A Review of the 2019 Novel Coronavirus (Covid-19): Immunopathogenesis, Molecular Biology and Clinical Aspects. 2020;23(1):8-21.
Omidi A, Shatizadeh Malekshahi S, Veisi PJJoAUoMS. Extra Pulmonary Manifestations of COVID-19: A Narrative Review. 2020;23:0-.
Kabashneh S, Ali H, Alkassis SJC. Multi-Organ Failure in a Patient With Diabetes due to COVID-19 With Clear Lungs. 2020;12(5).
Dariya B, Nagaraju GPJC, Reviews GF. Understanding novel COVID-19: Its impact on organ failure and risk assessment for diabetic and cancer patients. 2020.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. 2020;395(10223):497-506.
Pan A, Liu L, Wang C, Guo H, Hao X, Wang Q, et al. Association of public health interventions with the epidemiology of the COVID-19 outbreak in Wuhan, China. Jama. 2020.
Chan JF-W, Zhang AJ, Yuan S, Poon VK-M, Chan CC-S, Lee AC-Y, et al. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. 2020.
Yang X, Yu Y, Xu J, Shu H, Liu H, Wu Y, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. 2020;8(5):475-81.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. 2020;323(11):1061-9.
Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. 2020;5(7):802-10.
Zheng Y-Y, Ma Y-T, Zhang J-Y, Xie XJNRC. COVID-19 and the cardiovascular system. 2020;17(5):259-60.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. 2020;395(10223):507-13.
Wang T, Hu M, Chen X, Fu Y, Lei C, Dong H, et al. Caution on kidney dysfunctions of 2019-nCoV patients. 2020.
Sun J, Aghemo A, Forner A, Valenti L. COVID‐19 and liver disease. Wiley Online Library; 2020.
Zhang C, Shi L, Wang F-SJTlG, hepatology. Liver injury in COVID-19: management and challenges. 2020;5(5):428-30.
Terpos E, Ntanasis‐Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, et al. Hematological findings and complications of COVID‐19. 2020.
Batlle D, Soler MJ, Sparks MA, Hiremath S, South AM, Welling PA, et al. Acute kidney injury in COVID-19: emerging evidence of a distinct pathophysiology. 2020.
Zaim S, Chong JH, Sankaranarayanan V, Harky AJCPiC. COVID-19 and multi-organ response. 2020:100618.
Liao Y-C, Liang W-G, Chen F-W, Hsu J-H, Yang J-J, Chang M-SJTJoI. IL-19 induces production of IL-6 and TNF-α and results in cell apoptosis through TNF-α. 2002;169(8):4288-97.
Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh C-L, Abiona O, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. 2020;367(6483):1260-3.
Xu P, Zhou Q, Xu JJAoH. Mechanism of thrombocytopenia in COVID-19 patients. 2020:1-4.
Deng Y, Liu W, Liu K, Fang Y-Y, Shang J, Zhou L, et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study. 2020;133(11):1261-7.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet journal. 2020;395(10229):1054 - 62.
Li T, Lu H, Zhang WJEM, Infections. Clinical observation and management of COVID-19 patients. 2020;9(1):687-90.
Tang N, Li D, Wang X, Sun ZJJot, haemostasis. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. 2020;18(4):844-7.
Taheri SJDoH. A Review on Coronavirus Disease (COVID-19) and What is Known about it. 2020;11(1):87-93.
Wu C, Hu X, Song J, Du C, Xu J, Yang D, et al. Heart injury signs are associated with higher and earlier mortality in coronavirus disease 2019 (COVID-19). 2020.
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