SARS-CoV-2 Antigen Rapid Test in The Emergency Department; a Diagnostic Accuracy Study
Iranian Journal of Emergency Medicine,
Vol. 10 No. 1 (2023),
30 November 2022
,
Page e1
https://doi.org/10.22037/ijem.v10i1.39247
Abstract
Title: Evaluation of diagnostic value of SARS-CoV-2 rapid diagnostic test in patients with Covid-19
Introduction: The standard RT-PCR test is a time-consuming diagnostic test with difficult accessibility and high cost, so in order to early diagnose and prevent the spread of Covid-19 disease, access to a quick, inexpensive diagnostic test with easy access is essential. This study aimed to evaluate diagnostic value of SARS-CoV-2 rapid diagnostic test in patients with Covid-19.
Materials & Methods: The present study is a cross-sectional study in type of diagnostic value that was performed on 188 patients with symptoms of Covid-19 referred to the emergency department of Imam Hossein and Shohadaye Tajrish hospitals in Tehran. In this study, SARS-CoV-2 rapid diagnostic test was performed immediately after sampling and according to the manufacturer's instructions (reading in 10 minutes). Then chest CT scan was performed less immediately after collecting samples to compare with the results of rapid antigen detection test. Data were collected and analyzed using Spss software V.26 and descriptive-mean and Chi-square statistical tests.
Results: Results showed that out of 83 patients who were diagnosed with Covid-19 positively based on rapid diagnostic test, all of them (100%) were also positive based on chest CT scan results, and out of 100 patients diagnosed Covid-19 negative based on rapid diagnostic test, 42 patients (42%) were true negative and 58 were positive base of chest CT scan results. The sensitivity of the rapid diagnostic test compared to chest CT scan was 100%, its specificity was 42%, its positive predictive value was 58.86% and its negative predictive value was 100%.
Conclusion: Due to the high accuracy and rapid diagnostic of rapid diagnostic test (SARS-CoV-2), this test is a valid and reliable tool for rapid diagnosis of Covid-19 disease in emergency cases.
- COVID-19; SARS-CoV-2; rapid test; diagnostic testing; antigen test; diagnosis
How to Cite
References
Yüce, M., E. Filiztekin, and K.G. Özkaya, COVID-19 diagnosis -A review of current methods. Biosens Bioelectron, 2021. 172: p. 112752.
Rai, P., et al., Detection technologies and recent developments in the diagnosis of COVID-19 infection. Appl Microbiol Biotechnol, 2021. 105(2): p. 441-455.
Bhusal, L., et al., Virology, Clinical Features and Diagnosis of COVID 19: Review Analysis. Kathmandu Univ Med J (KUMJ), 2020. 18(70): p. 75-79.
Moshref, M., et al., A Review on Rapid Detection Methods of COVID-19. Journal of Marine Medicine, 2021. 3(4): p. 96-110.
Lisboa Bastos, M., et al., Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis. BMJ, 2020. 370: p. m2516.
Hoffman, T., et al., Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2. Infect Ecol Epidemiol, 2020. 10(1): p. 1754538.
Ravi, N., et al., Diagnostics for SARS-CoV-2 detection: A comprehensive review of the FDA-EUA COVID-19 testing landscape. Biosens Bioelectron, 2020. 165: p. 112454.
Falzone, L., et al., Current and innovative methods for the diagnosis of COVID‑19 infection (Review). Int J Mol Med, 2021. 47(6).
Cheng, C.C., et al., Evaluation of a Rapid Antigen Test for the Diagnosis of SARS-CoV-2 during the COVID-19 Pandemic. Inquiry, 2022. 59: p. 469580221105354.
Scohy, A., et al., Low performance of rapid antigen detection test as frontline testing for COVID-19 diagnosis. J Clin Virol, 2020. 129: p. 104455.
Winkel, B., et al., Screening for SARS-CoV-2 infection in asymptomatic individuals using the Panbio COVID-19 antigen rapid test (Abbott) compared with RT-PCR: a prospective cohort study. BMJ Open, 2021. 11(10): p. e048206.
Diez Flecha, C., et al., [Internal validity of a rapid test for COVID-19 antigens in a nursing home]. Semergen, 2021. 47(5): p. 332-336.
Yamayoshi, S., et al., Comparison of Rapid Antigen Tests for COVID-19. Viruses, 2020. 12(12).
Möckel, M., et al., SARS-CoV-2 antigen rapid immunoassay for diagnosis of COVID-19 in the emergency department. Biomarkers, 2021. 26(3): p. 213-220.
Favresse, J., et al., Head-to-Head Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 Infection. J Clin Med, 2021. 10(2).
Mak, G.C., et al., Evaluation of rapid antigen test for detection of SARS-CoV-2 virus. J Clin Virol, 2020. 129: p. 104500.
Soleimani, R., et al., Rapid COVID-19 antigenic tests: Usefulness of a modified method for diagnosis. J Med Virol, 2021. 93(9): p. 5655-5659.
Linares, M., et al., Panbio antigen rapid test is reliable to diagnose SARS-CoV-2 infection in the first 7 days after the onset of symptoms. J Clin Virol, 2020. 133: p. 104659.
Peeling, R.W., et al., Scaling up COVID-19 rapid antigen tests: promises and challenges. Lancet Infect Dis, 2021. 21(9): p. e290-e295.
Chaimayo, C., et al., Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand. Virol J, 2020. 17(1): p. 177.
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