Association of Genetics traits with obesity in men: A review on the current knowledge in Iran
Men's Health Journal,
Vol. 4 No. 1 (2020),
19 April 2020
Today, obesity is one of the leading causes of death. It also causes other diseases such as diabetes, cardiovascular disease, and various types of cancer. Obesity is a multifactorial disease caused by factors such as genetics and lifestyle. However, scientists imagine that about 40-70% of the disease originates from genetics. In this review, we examined the role of different genes in obesity by examining 30 articles published on the role of genetics in the obesity of Iranian men, according to their BMI, comorbidities and family history. We concluded that most of the research has been done on the FTO, Hind III and S447 genes. We also showed an apparent relationship between these genes and obesity. Finally, according to studies, FTO can be considered as the most important and strongest contributor to obesity.
How to Cite
World Health Statistics; World health Organization. Monitoring health for the SDGs, 2019. available at: https://www.who.int/gho/publications/world_health_statistics/2019/en/
World Health Organization: Factsheets on Obesity and Overweight. (2019). Available at:https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight.
World Health Organization (2019): Country report, available at: https://www.who.int/countries/irn/en/.
Biabangard-zak A, Golalipour M, Hadadchi G. High Prevalence of Y chromosome Partial Microdeletions in Overweight Men. Avicenna Journal of Medical Biotechnology. 2015;7(3):97-100.
Yaghoubi H, Hagh M, Radjabalizadeh K. Association of adenosine deaminase (ADA) gene 4223A/C polymorphism with obesity in Ardabil, Iran. Pathobiology Research. 2017;20(2):79-87.
Kalantari N, Keshavarz-Mohammadi N, Izadi P, Doaei, S., , Gholamalizadeh M, Eini-Zinab H, Salonurmi T, et al. A haplotype of three SNPs in FTO had a strong association with body composition and BMI in Iranian male adolescents. PLoS One. 2018;13(4):e0195589. doi: 10.1371/journal.pone..
Pigeyre M, Yazdi FT, Kaur Y, Meyre D. Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity. Clin Sci 2016;130: 943–86.
Hosseini-Esfahanin F, Koochakpoor G, Mirmiran P, Daneshpour MS, Azizi F. Dietary patterns modify the association between fat mass and obesity-associated genetic variants and changes in obesity phenotypes. Br J Nutr 2019 121(11):1247-54. doi: 10.017/S0007114519000643.
Gutin I. In BMI we trust: reframing the body mass index as a measure of health Social Theory & Health. 2017;16(3):256–71.
Nategh F, Yaghoubi. H., RajabaliZadeh K. Investigation of relationship between the C825T polymorphism in GNB3 gene and obesity in the population of Ardabil, Iran. . Journal of Molecular and Cellular Research. 2018;30(4):422-9.
Javanrouh N, Daneshpour MS, Soltanian AR, Tapak L. Kernel machine SNP set analysis provides new insight into the association between obesity and polymorphisms located on the chromosomal 16q.12.2 region: Tehran Lipid and Glucose Study. . 1-18. Gene. 2018;5(658):146-51. doi: 10.1016/j.gene.2018.03.006.
Mohamad Rezaii H, Kalantari M, Mahmazi S. Association of UCP3 (Uncoupling protein 3) Gene -55C/T Polymorphism and obesity in a Juvenile Population of Iran. Journal of Fasa University of Medical Sciences. 2018;8(1):594-600.
Kalantari N, Keshavarz-Mohammadi N, Izadi P, Gholamalizadeh M, Doaei S, Eini-Zinab H, et al. A complete linkage disequilibrium in a haplotype of three SNPs in Fat Mass and Obesity associated (FTO) gene was strongly associated with anthropometric indices after controlling for calorie intake and physical activity. BMC Medical Genetics. 2018;19(146):1-6.
Hosseini-Esfahani F, Koochakpoor G, S. , Daneshpour M, Mirmiran P, Sedaghati-khayat B, Azizi F. The interaction of fat mass and obesity associated gene polymorphisms and dietary fiber intake in relation to obesity phenotypes. . Scientific Reports. 2017;7:18057.
Hosseini-Esfahani F, Koochakpoor G, S. , Daneshpour M, Sedaghati-khayat B, Mirmiran P, Azizi F. Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes. Nutrients. 1-13. Nutrients. 2017;9(10):E1064. doi: 10.3390/nu9101064.
Askari G, Heidari-Beni M, Mansourian M, Motlagh ME, Kelishadi R. Interaction of lipoprotein lipase polymorphisms with body mass index and birth weight to modulate lipid profiles in children and adolescents: the CASPIAN-III Study. Sao Paulo Medical Journal. 2015;134(2):121-9.
Emamian M, Avan A, Pasdar A, Mirhafez SR, Sadeghzadeh M, Saleh Moghadam M, et al. The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationshipwith lipid profile in human serum of obese individuals. . Gene 2015;558(2):195-9. doi: 10.1016/j.gene.2014.12.070.
Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, et al. Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure. Cell. 2005;123(3):493–505.
Khalilitehrani A, Qorbani M, Hosseini S, Pishva H. The association of MC4R rs17782313 polymorphism with dietary intake in Iranian adults. . Gene. 2015;563 (1): 125-9. doi: 10.1016/j.gene.2015.03.013.
Eshraghi P, Hedayati M, Daneshpour MS, Mirmiran P, Azizi F. Association of body mass index and Trp64Arg polymorphism of the β3-adrenoreceptor gene and leptin level in Tehran Lipid and Glucose Study. British Journal of Biomedical Science. 2007;64(3):117-20.
Shajarian M, Rafiee L, Naji-Esfahani H, Haghjooy-Javanmard S, Nizal S. Association of RBP4 gene variants with adverse lipid profile and obesity. Gene. 1-5. Gene 2015;561(1):1-5. doi: 10.1016/j.gene.2014.12.071.
Zarkesh M, Daneshpour MS, Faam B, Hedayati M, Azizi F. Is there any association of apolipoprotein E gene polymorphism with obesity status and lipid profiles? Tehran Lipid and Glucose Study (TLGS). Gene 2012;509(2):282-5. doi: 10.1016/j.gene.2012.07.048.
Rooki H, Ghayour-Mobarhan M, Pourhosseingholi MA, Azarpazhooh MR, Ebrahimi M, Ferns, G., , Zali MR. Association of LXRa polymorphisms with obesity and obesity-related phenotypes in an Iranian population Journal of the society for the study of human biology. 2014;41(3):214–9.
Zadeh-Vakili A, Faam B, Daneshpour MS, Hedayati M, Azizi F. Association of CD36 Gene Variants and Metabolic Syndrome in Iranians. Genetic Testing and Molecular Biomarkers. 2012;16(4): 234–8.
Debette S, Visvikis-Siest S, Chen M-H, Ndiaye N-C, Song C, Destefano A, et al. Identification of cis- and trans-Acting Genetic Variants Explaining Up to Half the Variation in Circulating Vascular Endothelial Growth Factor Levels. Circulation Research. 2011;109(5):554–63.
Azimi-Nezhad M, Mirhafez SR, G. , Stathopoulou M, Murray H, Ndiaye NC, Bahrami A, et al. The relationship between vascular endothelial growth factor cis- and trans-acting genetic variants and metabolic syndrome. The American Journal of the Medical Sciences. 2018;355(6):559-65. doi: 10.1016/j.amjms.2018.03.009.
Mardan-Nik M, Pasdar A, Jamialahmadi K, Avan A, Mohebati M, Esmaily H, et al. Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity. Annals of Human Biology. 2016;43(6):542–6.
Shafaghi K, Mohd Shariff Z, Mohd Taib MN, Abdul Rahman H, Ghayour Mobarhan M, Jabbari H. Parental body mass index is associated with adolescent overweight and obesity in Mashhad, Iran. Asia Pacific Journal of Clinical Nutrition. 2014;23(2):225-31.
Daneshpour MS, Rebai A, Houshmand M, Alfadhli S, Zeinali S, Hedayati M, et al. 8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome. European Journal of Clinical Investigation. 2011;41(10): 1105–12.
Mahmoudi T, Majidzadeh-A K, Karimi K, Farahani H, Dabiri R, Nobakht H, et al. Gly972Arg variant of insulin receptor substrate 1 gene and colorectal cancer risk in overweight/ obese subjects. International Journal of Biological Markers. 2016;31(1): e68-e72.
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