Survival of Gastric Cancer Patients in Iran: A Systematic Review and Meta-Analysis
Gastroenterology and Hepatology from Bed to Bench,
Objective: Gastric cancer is one of the most common cancers in Iran with high mortality. The aim of this study was to estimate the survival rates among Iranian gastric cancer patients and to evaluate if the survival has improved during last three decades.
Materials and Methods: A PRISMA-based systematic review of all published studies addressing gastric cancer survival in Iran was performed. International databases of Scopus, Web of Science, PubMed, and Iranian databases were included in the study. The study included databases from their inception till February 2022. Due to the inherent heterogeneity, we use a random effect model to pool the survivals in three categories of one, three, and five-year survivals.
Results: Thirty-three studies with total cases of 17,207 were included into the study. The overall (pooled) one, three, and five-year survivals were estimated as 58.9% (95% CI: 0.52, 0.66), 29.9% (95% CI: 0.25, 0.35), and 18.2% (95% CI: 0.15, 0.23), respectively. Results of subgroup analysis for the calendar years of study showed that the one, three and five-year survival rates increased during the last three decades but the results were not statistically significant. There was disparity in survival based on geographic distribution.
Conclusion: The results of our study clearly showed improvement in survival in last three decades indicating better access to treatment in recent years.