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Gastroenterology and Hepatology from Bed to Bench

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  3. Vol 10, No 3 (2017):Summer
  4. Original Article

ISSN: 2008-2258

Vol 10, No 3 (2017):Summer

Results of liver transplantation with donors older than 80 Years: A case - control study.

  • Francisco Javier Leon Diaz
  • Jose luis Fernandez Aguilar
  • Belinda Sanchez Perez
  • Custodia Montiel Casado
  • Jose Manuel Aranda Narvaez
  • Jose Antonio Perez Daga
  • Miguel Angel Suarez Munoz
  • Julio Santoyo Santoyo

Gastroenterology and Hepatology from Bed to Bench, , , Page 173-177
https://doi.org/10.22037/ghfbb.v0i0.995 Published 5 August 2017

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Abstract

Aim: The inclusion of elderly donors can increase the pool of organs available for transplant.

Background: To compare clinical outcomes and survival rates in patients who received livers from donors aged ? 80 years vs. younger donors.

Methods: We considered all liver transplantations performed in our unit between January 2006 and January 2015. Twelve patients received liver from a cadaveric donor aged ? 80 years (study group) and their outcomes were compared with those of patients who received liver from a younger donor (control group). This study was carried out to analyze the characteristics of donors and recipients, as well as the clinical course and survival of recipients.

Results: Statistically significant differences were observed in donors' age (55.6 ± 14.4 vs. 82.7 ± 2.7 years, p < 0.001), donors' ICU stay (p = 0.008), donors' ALT levels (p = 0.009) and donors' AST levels (p = 0.01). Statistically significant differences were found in ischemia time (p < 0.05). In total, 8.3% of the recipients of liver from a donor aged < 80 required retransplantation vs. 25% of recipients of donor’s ? 80 years. Patient survival at one, three and five years was 89%, 78.6% and 74.5%, respectively vs. 83.4%, 79.4% and 59.6% for the study group.

Conclusion: Livers from older donors can be safely used for transplantation with acceptable patient survival rates. However, graft survival rates are lower for recipients of livers from older donors as compared to younger donors, and survival only increased with retransplantation.

Keywords: Liver transplantation, Older donors, Octogenarians

Keywords:
  • liver transplantation
  • older donors
  • octogenarians.
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How to Cite

Leon Diaz, F. J., Fernandez Aguilar, J. luis, Perez, B. S., Montiel Casado, C., Aranda Narvaez, J. M., Perez Daga, J. A., Suarez Munoz, M. A., & Santoyo, J. S. (2017). Results of liver transplantation with donors older than 80 Years: A case - control study. Gastroenterology and Hepatology from Bed to Bench, 173-177. https://doi.org/10.22037/ghfbb.v0i0.995
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GHFBB journal is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Print ISSN: 2008-2258
Online ISSN: 2008-4234

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