Publisher: Research Institute for Gastroenterology and Liver Diseases (RIGLD)
  • Register
  • Login

Gastroenterology and Hepatology from Bed to Bench

  • Current
  • Archives
  • Announcements
  • Indexing & Abstracting
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
Advanced Search
  1. Home
  2. Archives
  3. Vol. 3 No. 3 (2010): Summer
  4. New Section Title Here

ISSN: 2008-2258

Summer
Vol. 3 No. 3 (2010)

Hepatitis B virus YMDD-motif mutations with emergence of lamivudine-resistant mutants: a threat to recovery

  • Muhammad Idrees
  • Zunaira Awan
  • Shazia Rafique
  • Irshad-ur Rehman
  • Haji Akbar
  • Sadia Butt
  • Sobia Manzoor
  • Liaqat Ali Khan
  • Saira Munir
  • Samia Afzal
  • Zareen Fatima
  • Bisma Rauff
  • Mahrukh Naudhani
  • Mohammad Ali
  • Sana saleem
  • Sadaf Badar

Gastroenterology and Hepatology from Bed to Bench, Vol. 3 No. 3 (2010),
https://doi.org/10.22037/ghfbb.v3i3.95 Published 20 June 2010

  • View Article
  • Download
  • Cite
  • Statastics
  • Share

Abstract

Hepatitis B virus (HBV) is a crucial public health problem with approximately 350 million affected people and a death rate of 0.5 to 1.2 million per year worldwide. It proceeds to end-stage liver diseases including cirrhosis with hepatic decompensation and hepatocellular carcinoma (HCC). Pakistan lies in the endemic region with 3% HBV carrier rate in the country. The differences in disease outcome and antiviral treatment response among HBV infected patients are variable in different regions of the world due to marked differences in HBV genotypes. These variants are different in their serological reactivity patterns, virus replication, liver disease severity and antiviral treatment responsiveness. The highly mutating nature of HBV is the major cause of its ever increasing antiviral resistance. Importantly the tyrosine-methionine-aspartate-aspartate (YMDD)-motif mutants emerge during prolonged lamivudine treatments that elicit immune clearance. This review deals with the HBV nature, mutation appearance and particularly emphasizes on lamivudine induced mutations in a conserved region (YMDD motif) which is further worsening the antiviral therapies with passage of time.
Keywords:
  • Hepatitis B virus
  • Mutants
  • Public problem
  • Drug resistance
  • Chronic carrier
  • PDF

How to Cite

Idrees, M., Awan, Z., Rafique, S., Rehman, I.- ur, Akbar, H., Butt, S., Manzoor, S., Ali Khan, L., Munir, S., Afzal, S., Fatima, Z., Rauff, B., Naudhani, M., Ali, M., saleem, S., & Badar, S. (2010). Hepatitis B virus YMDD-motif mutations with emergence of lamivudine-resistant mutants: a threat to recovery. Gastroenterology and Hepatology from Bed to Bench, 3(3). https://doi.org/10.22037/ghfbb.v3i3.95
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX
  • Abstract Viewed: 169 times
  • PDF Downloaded: 247 times

Download Statastics

  • Linkedin
  • Twitter
  • Facebook
  • Google Plus
  • Telegram
Open Journal Systems
Keywords
Current Issue
  • Atom logo
  • RSS2 logo
  • RSS1 logo
  • Home
  • Archives
  • Submissions
  • About the Journal
  • Editorial Team
  • Contact
The template of this website is designed by Sinaweb