Gastroenterology and Hepatology from Bed to Bench

Abstract

Aim: This study is aimed to elicit the possible correlation between breast and colon cancer from molecular prospectiveby analyzing and comparing pathway-based biomarkers.Background: Breast and colon cancer are known to be frequent causes of morbidity and mortality in men and womenaround the world. There is some evidence that while the incident of breast cancer in young women is high, it is reportedlower in the aged women. In fact, aged women are more prone to colorectal cancer than older men. . In addition, manystudies showed that several biomarkers are common among these malignancies.Patients and methods: The genes were retrieved and compared from KEGG database and WikiPathway, and subsequently,protein-protein interaction (PPI) network was constructed and analyzed using Cytoscape v:3.2.1 software and related algorithms.Results: More than forty common genes were identified among these malignancies; however, by pathways comparison,twenty genes are related to both breast and colon cancer. Centrality and cluster screening identified hub genes, includingSMAD2, SMAD3, (SMAD4, MYC), JUN, BAD, TP53. These seven genes are enriched in regulation of transforminggrowth factor beta receptor signaling pathway, positive regulation of Rac protein signal transduction, positive regulationof mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, and positive regulation ofmitotic metaphase/anaphase transition respectively.Conclusion: As there are numerous genes frequent between colorectal cancer and breast cancer, there may be a commonmolecular origin for these malignancies occurrences. It seems that breast cancer in females interferes with the rate ofcolorectal cancer incidence.Keywords: Colon cancer, Breast cancer, Protein-Protein Interaction Network, Gene ontology.(Please cite as: Zamanian-Azodi M, Rezaei-Tavirani M, Rahmati-Rad S, Hasanzadeh H, Rezaei Tavirani M, SeyyediSS. Protein-Protein Interaction Network could reveal