Ulcerative colitis associated with chronic granulomatous disease: case report
Gastroenterology and Hepatology from Bed to Bench,
Chronic Granulomatous Disease (CGD) is an inherited primary immunodeficiency disease which increases the body’ssusceptibility to infections caused by certain bacteria and fungi. CGD is a rare disease, caused by four genes, one type is 1Xlinked and the other three are “autosomal recessive”. Although clinical presentation is variable, but characteristic featuresare recurrent pneumonia, lymphadenitis, hepatic or other abscesses. Gastrointestinal tract symptoms are common in xlinkedrecessive form of CGD. These include gastric and esophageal obstruction and inflammatory bowel disease. GIinvolvement including small and large intestines, the findings of luminal narrowing and the presence of granuloma canmake it difficult to distinguish from Crohn’s disease. On the other hands according to the literature ulcerative colitis israrely reported in patients with CGD. Our case presented with ulcerative colitis with CGD.Keywords: Crohn’s disease, Chronic granulomatous disease, Ulcerative colitis.(Please cite as: Imanzade F, Sayarri A, Tajik P. Ulcerative colitis associated with chronic granulomatous disease:case report. Gastroenterol Hepatol Bed Bench 2015;8(3):233-235).
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