Gastroenterology and Hepatology from Bed to Bench

Abstract

Gastric adenocarcinoma is a common malignancy with high rate among other cancers in the world and many ethological causes have been introduced for which helicobacter pylori, as a gram-negative bacterium has been considered as an important pathological facilitating factor. This agent is also associated with more different digestive diseases, such as gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma. Recently some molecular aspects have been described by scientists which show role of some apoptotic genes and proteins for example:P53, Bcl2 ,C-Myc and Rb-suppressor systems in H pylori pathogenesis .Also the relationship between nitric oxide( NOSi genotype) with H pylori genes has been demonstrated in some studies, This mini-review has been aimed to explain better these  genetically aspects of Pylori pathogenesis.