Genetic and molecular aspects of Helicobacter pylori in gastritis, pre -cancerous conditions and gastric adenocrcinoma
Gastroenterology and Hepatology from Bed to Bench,
AbstractGastric adenocarcinoma is a common malignancy with high rate among other cancers in the world and many ethological causes have been introduced for which helicobacter pylori, as a gram-negative bacterium has been considered as an important pathological facilitating factor. This agent is also associated with more different digestive diseases, such as gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma. Recently some molecular aspects have been described by scientists which show role of some apoptotic genes and proteins for example:P53, Bcl2 ,C-Myc and Rb-suppressor systems in H pylori pathogenesis .Also the relationship between nitric oxide( NOSi genotype) with H pylori genes has been demonstrated in some studies, This mini-review has been aimed to explain better these genetically aspects of Pylori pathogenesis.
How to Cite
Shadifar, M., Ataee, R., Ataie, A., Heydari Gorgi, A. M., Nasri Nasrabadi, N., & Nouri, S. (2015). Genetic and molecular aspects of Helicobacter pylori in gastritis, pre -cancerous conditions and gastric adenocrcinoma. Gastroenterology and Hepatology from Bed to Bench, 8(Supplement), S15-S22. https://doi.org/10.22037/ghfbb.v8iSupplement.632
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