Gastroenterology and Hepatology from Bed to Bench

Abstract

Background & objectives: Shigellosis is caused by different species of Shigella and one of the most common causes of diarrhea in children. This disease is endemic in many developing countries including Iran.  The aim of this study was to determine the incidence of Shigella species and their antimicrobial suceptibility patterns in hospitalized children with shigellosis .

Methods: This prospective cross sectional study was conducted in a teaching hospital in Abadan , Iran during June 2011 to may 2013. Stool specimens were collected from paediatric age group. All isolates were confirmed as Shigella species by biochemical and serologic tests. Antibiotic sensitivity pattern of these isolates was studied by  disk diffusion Method.

Results : Among all 705 stool samples, 36(5.1%) yielded Shigella.  Of cases, 392 (55.6%) of  were female and 313 (44.4%) of them were male. The most common Shigella isolates were S.flexneri (n=19, 52.7%) followed by S.sonnei(n=11, 30.5%), S.boydii (n=4, 11.1%) and S.dysenteriae 2(5.5%). Of the Shigella isolates, (47.2%) showed resistance to tow or more antimicrobial agents. Resistance pattern against various antimicrobials were as follows: trimethoprim-sulphamethoxazole (80.5%), ampicillin (63.8%), tetracycline(58.3%), Chloramphenicol(33.3%), nalidixic acid(27.7%), cefixime(16.6%) and. Additionally, there was no resistance against ciprofloxacin and ceftriaxone.

Conclusion : The most common isolates was S.flexeneri followed by S.Sonei. There was no antibiotic resistance against ciprofloxacin and ceftriaxone. TMP-SMZ showed highest resistancy.